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Enzymatic Activity Assay from US Patent US20230391761: "SUBSTITUTED S-ALANINATE DERIVATIVES"
Assay data:17 Active, 14 Activity ≤ 1 nM, 17 Activity ≤ 1 µM, 17 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Human Cytochrome P450 Inhibition Assay from US Patent US11834414: "1-methyl-4-[(4-phenylphenyl)sulfonylmethyl]cyclohexyanol and 1-methyl-4-[[4-(2-pyridyl)phenyl]sulfonylmethyl]cyclohexanol compounds and their therapeutic use"
Assay data:5 Active, 15 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
qHTS for inhibitors of CYPIA2 against the NCATS DSHEA and TCM libraries
Assay data:275 Active, 13 Activity ≤ 1 µM, 964 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition Against Cytochrome P450 Isoenzymes from US Patent US20230331739: "INDOLO HEPTAMYL OXIME ANALOG CRYSTAL AS PARP INHIBITOR AND METHOD FOR PREPARING SAME"
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Target
CYP Enzyme (Cytocrome P450) Inhibition Assay from US Patent US20230303562: "PYRAZOLE COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF"
Assay data:6 Tested
SummaryRelated BioAssays by DepositorRelated BioAssays by Target
Cytochrome P450 Isoenzyme Inhibitory Activity Test from US Patent US11691965: "Method for preparing pyrrolidinyl urea derivative"
Assay data:1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of Cytochrome P450 Oxidase from US Patent US11643436: "Polypeptide compound, pharmaceutical composition, preparation method and application thereof"
CYP1A2 Inhibition Assay from US Patent US11629146: "Substituted [1,2,4]triazolo[4,3-a]pyrazines as modulators of sodium channel activity"
Assay data:28 Active, 14 Activity ≤ 1 µM, 46 Tested
Inhibition Assay from US Patent US11548860: "Pharmacophores, compounds and methods having application in the treatment of cancer through inhibition of CYP17A1 and CYP19A1"
Assay data:11 Active, 3 Activity ≤ 1 µM, 13 Tested
Cyp Inhibition from US Patent US11542242: "Substituted piperazines as selective HDAC1,2 inhibitors"
Assay data:2 Active, 10 Tested
CYP Inhibition Assay from US Patent US11505526: "Aryl-piperidine derivatives"
Assay data:2 Active, 3 Tested
Inhibition of CYP450 (unknown origin)
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of CYP1A2 in human liver microsomes at 10 uM using phenacetin as substrate for 5 mins followed by NADPH addition and measured after 10 mins by LC/MS/MS analysis relative to control
Inhibition of CYP1A2 in human liver microsomes at 0.01 to 30 uM using phenacetin as substrate in presence of NADPH by UPLC-MS/MS analysis
Assay data:1 Active, 6 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of CYP1A2 in human liver microsomes at 25 uM in the presence of NADPH
Inhibition of CYP1A2 (unknown origin) at 20 uM
Assay data:5 Tested
Inhibition of CYP1A2 in human liver microsomes
Assay data:2 Tested
Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate incubated for 5 to 45 mins in presence of NADPH by LC/MS analysis
Assay data:3 Tested
Inhibition of CYP1A2 in human liver microsomes using phenacetin at 10 uM in presence of NADPH incubated for 10 mins
Inhibition of CYP1A2 (unknown origin)
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