Related BioAssays, by Target Similarity (List) for PubChem BioAssay (S - PubChem BioAssay - NCBI

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Select item 19462841.

Inhibition of human PRMT1 by fluorescence-based SAHH-coupled assay

Source:: ChEMBL

Protein Target:: Protein arginine N-methyltransferase 1

Assay data:3 Active, 3 Tested

AID:: 1946284

Summary Related BioAssays by Target

Select item 19462792.

Inhibition of human PRMT1 using H4R3 S1ac and [3H]-SAM as substrate by AlphaLISA assay

Source:: ChEMBL

Protein Target:: Protein arginine N-methyltransferase 1

Assay data:1 Active, 1 Tested

AID:: 1946279

Summary Related BioAssays by Target

Select item 19341593.

Inhibition of PRMT8 (unknown origin) incubated for 15 mins measured after 60 min by AlphaLISA assay

Source:: ChEMBL

Protein Target:: Protein arginine N-methyltransferase 8

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1934159

Summary Related BioAssays by Target

Select item 19341434.

Inhibition of PRMT1 (unknown origin) incubated for 15 mins measured after 60 min by AlphaLISA assay

Source:: ChEMBL

Protein Target:: Protein arginine N-methyltransferase 1

Assay data:1 Activity ≤ 1 µM, 1 Tested

AID:: 1934143

Summary Related BioAssays by Target

Select item 19153765.

Selectivity interaction (Methyltransferase panel (Scintillation proximity assay (SPA))) EUB0000212b PRMT8

Source:: ChEMBL

Protein Target:: Protein arginine N-methyltransferase 8

Assay data:1 Tested

AID:: 1915376

Summary Related BioAssays by Target

Select item 19153736.

Selectivity interaction (Methyltransferase panel (Scintillation proximity assay (SPA))) EUB0000212b PRMT1

Source:: ChEMBL

Protein Target:: Protein arginine N-methyltransferase 1

Assay data:1 Tested

AID:: 1915373

Summary Related BioAssays by Target

Select item 19153487.

Selectivity interaction (Methyltransferase panel) EUB0000196bCl PRMT8

Source:: ChEMBL

Protein Target:: Protein arginine N-methyltransferase 8

Assay data:1 Tested

AID:: 1915348

Summary Related BioAssays by Target

Select item 19153468.

Selectivity interaction (Methyltransferase panel) EUB0000196bCl PRMT1

Source:: ChEMBL

Protein Target:: Protein arginine N-methyltransferase 1

Assay data:1 Tested

AID:: 1915346

Summary Related BioAssays by Target

Select item 19152589.

Selectivity interaction (HMT panel) EUB0000194b PRMT8

Source:: ChEMBL

Protein Target:: Protein arginine N-methyltransferase 8

Assay data:1 Tested

AID:: 1915258

Summary Related BioAssays by Target

Select item 191525610.

Selectivity interaction (HMT panel) EUB0000194b PRMT1

Source:: ChEMBL

Protein Target:: Protein arginine N-methyltransferase 1

Assay data:1 Tested

AID:: 1915256

Summary Related BioAssays by Target

Select item 191436611.

Selectivity interaction (Protein methyltransferase panel (activity assay)) EUB0000211b PRMT8

Source:: ChEMBL

Protein Target:: Protein arginine N-methyltransferase 8

Assay data:1 Tested

AID:: 1914366

Summary Related BioAssays by Target

Select item 191436312.

Selectivity interaction (Protein methyltransferase panel (activity assay)) EUB0000211b PRMT1

Source:: ChEMBL

Protein Target:: Protein arginine N-methyltransferase 1

Assay data:1 Tested

AID:: 1914363

Summary Related BioAssays by Target

Select item 191335113.

Affinity Biochemical interaction (Scintillation proximity assay (SPA) ) EUB0000034d PRMT8

Source:: ChEMBL

Protein Target:: Protein arginine N-methyltransferase 8

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913351

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191334814.

Affinity Biochemical interaction (Scintillation proximity assay (SPA) ) EUB0000034d PRMT1

Source:: ChEMBL

Protein Target:: Protein arginine N-methyltransferase 1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913348

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191304215.

Affinity On-target Cellular interaction (Western Blot (inhibition of PRMT1 methyltransferase activity in MCF7 cells)) EUB0000034d PRMT1

Source:: ChEMBL

Protein Target:: Protein arginine N-methyltransferase 1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913042

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191130516.

Inhibition of PRMT1 (unknown origin) using histone H4 (1 to 21 residues) peptide as substrate incubated for 210 mins in presence of SAM by AlphaLISA assay

Source:: ChEMBL

Protein Target:: Protein arginine N-methyltransferase 1

Assay data:1 Active, 1 Tested

AID:: 1911305

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 188584517.

Inhibition of human PRMT1 at 10 uM by radioisotope-based filter binding assay

Source:: ChEMBL

Protein Target:: Protein arginine N-methyltransferase 1

Assay data:1 Tested

AID:: 1885845

Summary PubMed Citation Related BioAssays by Target

Select item 188307518.

Inhibition of human full length recombinant his-tagged PRMT8 (61 to 394 residues) using histone H4 as substrate incubated for 20 mins in presence of [3H]-SAM by radioisotope-based filter assay

Source:: ChEMBL

Protein Target:: Protein arginine N-methyltransferase 8

Assay data:7 Active, 8 Tested

AID:: 1883075

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 188306919.

Inhibition of human full length recombinant GST-tagged PRMT1 (2 to 371 residues) using histone H4 as substrate incubated for 20 mins in presence of [3H]-SAM by radioisotope-based filter assay

Source:: ChEMBL

Protein Target:: Protein arginine N-methyltransferase 1

Assay data:6 Active, 2 Activity ≤ 1 µM, 8 Tested

AID:: 1883069

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 188306820.

Inhibition of recombinant human PRMT1 assessed as residual activity using biotinylated histone H4 (1 to 21) as substrate incubated for 60 mins in presence of SAM by AlphaLISA method

Source:: ChEMBL

Protein Target:: Protein arginine N-methyltransferase 1

Assay data:5 Active, 1 Activity ≤ 1 µM, 27 Tested

AID:: 1883068

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

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Proteins (5)
BioAssays with protein sequences specified as targets

BioActivity

Active Compounds (118)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (1)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (34)
BioAssays with the active concentration of tested reagents less than 1 micromolar

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BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (124)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (2)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose

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BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

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Literature Extraction (272)
BioAssays extracted from the literature
NIH MLP (3)
BioAssays deposited by the NIH Molecular Libraries Program
Other (11)
BioAssays deposited by other experimentalists

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