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Biosensor transport assay for SLC1A3 using HEK293-SLC1A3-WTOE cells
Assay data:1 Active, 2 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of the Excitatory Amino Acid Transporter 1 (EAAT1, SLC1A3) as assessed by a phenotypic impedance-based assay detecting changes in cell morphology by L-glutamate uptake in HEK-293 JumpIN-SLC1A3 cells (PubChem AID: 1745862)
Assay data:6 Tested
SummaryPubMed CitationRelated BioAssays by Target
Substrate uptake by the Excitatory Amino Acid Transporter 1 (EAAT1, SLC1A3) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC1A3 cells (PubChem AID: 1745864)
Assay data:3 Tested
SummaryRelated BioAssays by Target
Membrane potential based transport assay for SLC1A3 using HEK293 JumpIn SLC1A3 OE cells
Assay data:3 Active, 3 Tested
Impedance-based phenotypic for SLC1A3 using HEK JumpIn SLC1A3 OE cells
Assay data:6 Active, 1 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of human EAAT1 transfected in mouse C17.2 cells assessed as inhibition of [3H]-D-aspartate uptake incubated for 5 mins by liquid scintillation counting analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human EAAT1 transfected in HEK293 cells assessed as inhibition of [3H]-D-aspartate uptake incubated for 4 mins by TopCount scintillation counting analysis
Assay data:5 Active, 3 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of rat EAAT4 transfected in human tsA201 cells assessed as inhibition of [3H]-D-aspartate uptake incubated for 4 mins by TopCount scintillation counting analysis
Assay data:5 Active, 6 Tested
Inhibition of human EAAT1 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 5 mins by liquid scintillation counting method
Assay data:37 Tested
Inhibition of human EAAT1 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake at 10 uM incubated for 5 mins by liquid scintillation counting method
Inhibition of EAAT1 (unknown origin) stably expressed in HEK293 cells assessed as reduction in [14C]glutamate uptake incubated for 5 mins by microbeta scintillation counting method
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of EAAT1 (unknown origin) transiently expressed in COS1 cells by [14C]glutamate based uptake assay
Inhibition of human EAAT1 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake after 15 mins by TopCount scintillation counting method
Assay data:4 Tested
Potency index, ratio of IC50 for NBI59159 to IC50 for test compound for inhibition of human EAAT1 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method
Assay data:1 Tested
Potency index, ratio of IC50 for WAY-213613 to IC50 for test compound for inhibition of rat EAAT4 expressed in tsA201 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method
Potency index, ratio of IC50 for WAY-213613 to IC50 for test compound for inhibition of human EAAT1 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method
Potency index, ratio of IC50 for DL-TBOA to IC50 for test compound for inhibition of rat EAAT4 expressed in tsA201 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method
Assay data:2 Tested
Potency index, ratio of IC50 for DL-TBOA to IC50 for test compound for inhibition of human EAAT1 expressed in HEK293 cells assessed as reduction in [3H]-D-Asp uptake incubated for 4 mins by scintillation counting method
Inhibition of human EAAT1 expressed in HEK293 cells assessed as reduction in EC80 L-glutamate-induced response at 300 uM co-applied with L-glutamate addition by fluorescence-based FLIPR membrane potential blue assay
Assay data:10 Active, 10 Tested
Inhibition of human EAAT1 expressed in HEK293 cells assessed as reduction in EC80 L-glutamate-induced response at 300 uM pre-incubated before L-glutamate addition by fluorescence-based FLIPR membrane potential blue assay
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