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Kinase (PDGFRα, PDGFRβ, ABL1 and FLT3) Inhibition Test of Compounds from US Patent US20230312529: "PYRIMIDINE SMALL-MOLECULE COMPOUND AND APPLICATION THEREOF"
Assay data:13 Active, 13 Activity ≤ 1 µM, 13 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
PDGFRα Kinase Assay from US Patent US11679110: "Methods of treating disorders using CSF1R inhibitors"
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Enzyme-linked immunosorbent assay (ELISA) from US Patent US11655239: "Fused ring pyrimidine amino compound and preparation method, pharmaceutical composition, and use thereof"
Assay data:32 Active, 18 Activity ≤ 1 nM, 32 Activity ≤ 1 µM, 32 Tested
Kinase Activity Assay from US Patent US11591328: "Highly active CSF1R inhibitor compound"
IC50 Kinase Assays from US Patent US11542261: "Substituted Imidazo[1,2-a]-pyridines as IRAK 1/4 and FLT3 inhibitors"
Assay data:50 Active, 8 Activity ≤ 1 nM, 45 Activity ≤ 1 µM, 50 Tested
HotSpot Assay from US Patent US11542261: "Substituted Imidazo[1,2-a]-pyridines as IRAK 1/4 and FLT3 inhibitors"
Assay data:30 Active, 6 Activity ≤ 1 nM, 30 Activity ≤ 1 µM, 30 Tested
In vitro kinase inhibition assay from US Patent US11505527: "Tetrahydroquinoline derivatives and a process of preparation thereof"
Assay data:3 Active, 3 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
Selectivity interaction (Kinase Profiler (Millipore)) EUB0000603a PDGFRA
Assay data:1 Tested
SummaryRelated BioAssays by Target
Selectivity interaction (Enzymatic assay (Bayer)) EUB0000713a PDGFRB
Selectivity interaction (KinomeScan (DiscoverX)) EUB0000321b PDGFRB
Selectivity interaction (NanoBRET assay (HEK293T cells)) EUB0000321b PDGFRB
Selectivity interaction (NanoBRET assay (HEK293T cells)) EUB0000321b PDGFRA
Selectivity interaction (KinomeScan (DiscoverX)) EUB0000321b PDGFRA
Selectivity interaction (KinomeScan (DiscoverX)) EUB0000698a PDGFRB
Selectivity interaction (Kinase panel (enzymatic assay)) EUB0000698a PDGFRB
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Selectivity interaction (SelectScreen (Invitrogen)) EUB0000679a PDGFRA
Selectivity interaction (KinomeScan (DiscoverX)) EUB0000634a PDGFRB
Selectivity interaction (KinomeScan (DiscoverX)) EUB0000147b PDGFRB
Selectivity interaction (Ambit kinome screening platform (Ambit phage-based competition binding assay)) EUB0000624a PDGFRB
Selectivity interaction (Ambit kinome screening platform (Ambit phage-based competition binding assay)) EUB0000624a PDGFRA
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