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MAOA and MAOB In Vitro Activity Assay from US Patent US11873292: "Trans-indoline cyclopropylamine chemical compound, and method for preparation, pharmaceutical composition, and use thereof"
Assay data:3 Active, 32 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Target
MAO-Glo Assay from US Patent US11787791: "Inhibitors of VAP-1"
Assay data:81 Active, 38 Activity ≤ 1 µM, 90 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
MAO Assay from US Patent US20230295140: "INHIBITORS OF VAP-1"
Inhibition Activity of the Compound on rhVAP-1 and MAO-A/B from US Patent US11649233: "Halo-allylamine SSAO/VAP-1 inhibitor and use thereof"
Assay data:18 Active, 18 Activity ≤ 1 µM, 18 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Diamine oxidase (DAO) selectivity assay from US Patent US11608330: "Methylamine derivatives as lysysl oxidase inhibitors for the treatment of cancer"
Assay data:44 Tested
SummaryRelated BioAssays by DepositorRelated BioAssays by Target
Monoamine Oxidase B (MAO-B) Selectivity Assay from US Patent US11608330: "Methylamine derivatives as lysysl oxidase inhibitors for the treatment of cancer"
Assay data:48 Tested
Competitive inhibition of human recombinant MAO-B assessed as inhibitory constant using varying levels of kynuramine as substrate by Lineweaver-burk plot analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Competitive inhibition of human recombinant MAO-A assessed as inhibitory constant using varying levels of kynuramine as substrate by Lineweaver-burk plot analysis
Inhibition of human recombinant MAO-B assessed as inhibition of 4-hydroxyquinoline formation using kynuramine as substrate incubated for 20 mins by fluorescence spectrophotometry
Assay data:12 Active, 10 Activity ≤ 1 µM, 12 Tested
Inhibition of human recombinant MAO-A assessed as inhibition of 4-hydroxyquinoline formation using kynuramine as substrate incubated for 20 mins by fluorescence spectrophotometry
Assay data:14 Active, 11 Activity ≤ 1 µM, 14 Tested
Inhibition of human MAO-A
Assay data:19 Active, 19 Activity ≤ 1 µM, 19 Tested
Inhibition of recombinant human MAO-B
Assay data:19 Active, 8 Activity ≤ 1 µM, 25 Tested
In vivo inhibition of MAO-B in resperine-induced mouse assessed as decrease in MAO-B activity in brain at 10 mg/kg
Assay data:4 Active, 4 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Reversible inhibition of MAO-B in mouse brain assessed as MAO-B activity recovered within 5 hrs at 10 mg/kg when administered as single dose
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Reversible inhibition of MAO-B in mouse brain assessed as MAO-B activity recovered at 24 hrs at 10 mg/kg when administered as single dose
Reversible inhibition of MAO-B in mouse brain assessed as MAO-B activity recovered after 4 hrs at 10 mg/kg when administered as single dose
Assay data:1 Tested
Reversible inhibition of MAO-B in mouse brain assessed as MAO-B activity recovered at 21 hrs at 10 mg/kg when administered as single dose
Reversible inhibition of MAO-B in mouse brain assessed as MAO-B activity recovered after 6 hrs at 10 mg/kg when administered as single dose
Displacement of 14C-5-hydroxytryptamine creatinine disulfate from MAO-A (unknown origin) preincubated for 60 mins followed by substrate addition measured after 30 mins in presence of selegiline by liquid scintillation counting method
Displacement of 14C-phenylethylamine from MAO-B (unknown origin) preincubated for 60 mins followed by substrate addition measured after 20 mins in presence of clorgyline by liquid scintillation counting method
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