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Inhibition Assay from US Patent US10695334: "Heteroaromatic carboxamide derivatives as plasma kallikrein inhibitors"
Assay data:56 Tested
SummaryRelated BioAssays by DepositorRelated BioAssays by Target
Substrate activity at human thymidine kinase 1 assessed as Km incubated for 24 hrs
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to TK1 in human NCI-H358 cells at 1 uM by mass spectrometry based pull down assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Competitive inhibition of thymidine kinase in mouse Ehrlich's ascites cells
Assay data:1 Tested
Inhibition of thymidine kinase in BHK21 (C13) cells using [14C]thymidine at 50 uM after 10 mins by liquid scintillation spectrometer analysis relative to control in presence of Mg2+
Inhibition of thymidine kinase in BHK21 (C13) cells using [14C]thymidine at 200 uM after 10 mins by liquid scintillation spectrometer analysis relative to control in presence of Mg2+
Assay data:2 Active, 2 Tested
Inhibition of thymidine kinase in BHK21 (C13) cells using [14C]thymidine at 100 to 200 uM after 10 mins by liquid scintillation spectrometer analysis relative to control in presence of Mg2+
Inhibition of human cytoplasmic thymidine kinase
Activity at thymidine kinase in BHK21 (C13) cells at 400 uM after 30 mins relative to thymidine
Inhibition of thymidine kinase in BHK21 (C13) cells using thymidine as substrate assessed as formation of TMP at 2 mM after 2 hrs
Assay data:4 Tested
Activity at thymidine kinase in BHK21 (C13) cells at 54 to 542 uM after 30 mins relative to thymidine
Activity at thymidine kinase in BHK21 (C13) cells at 60 uM after 30 mins relative to thymidine
Activity at thymidine kinase in BHK21 (C13) cells at 350 uM after 30 mins relative to thymidine
Mixed type inhibition of thymidine kinase in BHK21 (C13) cells using thymidine as substrate assessed as formation of TMP by Lineweaver-Burk plot analysis
Non-competitive inhibition of thymidine kinase in BHK21 (C13) cells using thymidine as substrate assessed as formation of TMP by Lineweaver-Burk plot analysis
Assay data:5 Tested
Competitive inhibition of thymidine kinase in BHK21 (C13) cells using thymidine as substrate assessed as formation of TMP by Lineweaver-Burk plot analysis
Assay data:19 Tested
Inhibition of thymidine kinase in BHK21 (C13) cells using thymidine as substrate assessed as formation of TMP
Inhibition of thymidine kinase in BHK21 (C13) cells using thymidine as substrate assessed as formation of TMP at 0.28 mM
Inhibition of thymidine kinase in BHK21 (C13) cells using thymidine as substrate assessed as formation of TMP at 5.6 mM
Inhibition of thymidine kinase in BHK21 (C13) cells using thymidine as substrate assessed as formation of TMP at 1.4 mM
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