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Inhibition Assay from US Patent US11608309: "Curcumin analogues as zinc chelators and their uses"
Assay data:4 Active, 2 Activity ≤ 1 µM, 8 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of MMP-2 (unknown origin) using fTHP-15(FAM) as substrate at 10 uM
Assay data:9 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of MMP-2 (unknown origin) using fTHP-15(FAM) as substrate at 5 uM
Assay data:5 Tested
Inhibition of MMP-2 (unknown origin) using fTHP-15(FAM) as substrate
Assay data:4 Active, 2 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of recombinant human MMP13 using APMA and fTHP-15(FAM) as substrate preincubated for 30 mins followed by substrate addition by fluorescence microplate reader assay
Assay data:26 Active, 24 Activity ≤ 1 µM, 28 Tested
Prodrug conversion assessed as MMP-2 (unknown origin)-mediated drug release by measuring half life by HPLC analysis
Assay data:1 Tested
Selectivity interaction (MMPs panel (FRET assay)) EUB0000730a MMP2
SummaryRelated BioAssays by Target
Selectivity interaction (MMPs panel (FRET assay, + 1.25 % HSA)) EUB0000730a MMP13
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Selectivity interaction (MMPs panel (enzymatic assay)) EUB0000729a MMP2
Selectivity interaction (Lead profiling screen (Eurofins, enzymes, transporters, GPCRs, ion chanels)) EUB0000728a MMP2
Selectivity interaction (Lead profiling screen (Eurofins, enzymes, transporters, GPCRs, ion chanels)) EUB0000728a MMP13
Selectivity interaction (MMPs panel (Panlabs panel, Bayer)) EUB0000725a MMP2
Selectivity interaction (MMPs panel (Panlabs panel, Bayer)) EUB0000725a MMP13
Affinity Biochemical interaction (FRET assay) EUB0000730a MMP13
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Affinity Biochemical interaction (Enzyme inhibition assay) EUB0000729a MMP13
Affinity Biochemical interaction (FRET assay) EUB0000727a MMP13
Affinity Biochemical interaction (Enzyme inhibition assay) EUB0000726a MMP13
Affinity Phenotypic Cellular interaction (ELISA (bovine nasal cartilage (BNC) degradation assay, inhibition of full-length MMP-13-induced cartilage degradation)) EUB0000730a MMP13
Affinity Phenotypic Cellular interaction (Bovine nasal cartilage assay (inhibitory activity against collagen degradation)) EUB0000729a MMP13
Inhibition of recombinant human MMP2 at 100 nM
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