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Summary
ALK2 HTRF Assay from US Patent US11840546: "Imidazopyridazine compounds and uses thereof"
Assay data:4 Active, 4 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
In Vitro Enzymatic Activity Inhibition Test (TGFbetaR1) from US Patent US20230303562: "PYRAZOLE COMPOUND AND PREPARATION METHOD THEREFOR AND USE THEREOF"
Assay data:11 Active, 1 Activity ≤ 1 nM, 11 Activity ≤ 1 µM, 11 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
No assay from US Patent US11759530: "TKI permeability enhancers"
Assay data:9 Active, 9 Activity ≤ 1 µM, 11 Tested
LanthaScreen Eu Kinase Binding Assay from US Patent US11746103: "ALK-5 inhibitors and uses thereof"
Assay data:8 Active, 56 Activity ≤ 1 µM, 56 Tested
In Vitro Kinase Assay - Inhibition of ALK1/2/3/4/5/6 Kinases from US Patent US11702401: "Compounds and methods of use"
Assay data:33 Active, 32 Activity ≤ 1 µM, 36 Tested
Biochemical assay from US Patent US11661426: "Imidazole-containing inhibitors of ALK2 kinase"
Assay data:455 Active, 496 Activity ≤ 1 µM, 496 Tested
Luciferase Reporter Gene Assay for ALK2 and TGFbeta Activity from US Patent US11654147: "ALK2 inhibitors and methods for inhibiting BMP signaling"
Assay data:149 Active, 1 Activity ≤ 1 nM, 165 Activity ≤ 1 µM, 170 Tested
Selectivity interaction (KinomeScan (DiscoverX, competition-binding assay)) EUB0000207b ACVR1
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of ALK-2 (unknown origin)
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of ALK2 in human HeLa cells assessed as inhibition of SMAD1 phosphorylation
Assay data:12 Active, 9 Activity ≤ 1 µM, 14 Tested
Inhibition of ALK2 (unknown origin)
Assay data:28 Active, 26 Activity ≤ 1 µM, 28 Tested
Inhibition of human recombinant ALK2 (172 to 499 residues) expressed in baculovirus-infected insect cells by ADP-Glo kinase assay
Inhibition of ALK1 (unknown origin)
Assay data:28 Active, 23 Activity ≤ 1 µM, 29 Tested
Inhibition of GST-tagged human recombinant ALK2 (145 to 509 residues) expressed in baculovirus expression system using casein as substrate in presence of [gamma-32P]ATP incubated for 45 mins by Microscint-20 scintillation counting analysis
Inhibition of GST-tagged human recombinant ALK1 expressed in baculovirus expression system using casein as substrate in presence of [gamma-32P]ATP incubated for 45 mins by Microscint-20 scintillation counting analysis
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