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Invivo PROTAC activity at CRBN/MDM2 in human RS4-11 cells xenografted in mouse assessed as fold change in cleaved PARP protein level in tumor at 25 mg/kg, iv administered as single dose and measured after 24 hrs by Western blot analysis (Rvb = 1 to 1.2 No_unit)
Assay data:1 Tested
SummaryRelated BioAssays by Target
Invivo PROTAC activity at CRBN/MDM2 in human RS4-11 cells xenografted in mouse assessed as fold change in cleaved PARP protein level in tumor at 25 mg/kg, iv administered as single dose and measured after 6 hrs by Western blot analysis (Rvb = 1 to 1.2 No_unit)
Invivo PROTAC activity at CRBN/MDM2 in human RS4-11 cells xenografted in mouse assessed as fold change in cleaved PARP protein level in tumor at 25 mg/kg, iv administered as single dose and measured after 3 hrs by Western blot analysis (Rvb = 1 to 1.2 No_unit)
Invivo PROTAC activity at CRBN/MDM2 in human RS4-11 cells xenografted in mouse assessed as fold change in p21 protein level in tumor at 25 mg/kg, iv administered as single dose and measured after 24 hrs by Western blot analysis (Rvb = 1 No_unit)
Invivo PROTAC activity at CRBN/MDM2 in human RS4-11 cells xenografted in mouse assessed as fold change in p21 protein level in tumor at 25 mg/kg, iv administered as single dose and measured after 6 hrs by Western blot analysis (Rvb = 1 No_unit)
Invivo PROTAC activity at CRBN/MDM2 in human RS4-11 cells xenografted in mouse assessed as fold change in p21 protein level in tumor at 25 mg/kg, iv administered as single dose and measured after 3 hrs by Western blot analysis (Rvb = 1 No_unit)
Invivo PROTAC activity at CRBN/MDM2 in human RS4-11 cells xenografted in mouse assessed as fold change in p53 protein level in tumor at 25 mg/kg, iv administered as single dose and measured after 24 hrs by Western blot analysis (Rvb = 1 to 1.3 No_unit)
Invivo PROTAC activity at CRBN/MDM2 in human RS4-11 cells xenografted in mouse assessed as fold change in p53 protein level in tumor at 25 mg/kg, iv administered as single dose and measured after 6 hrs by Western blot analysis (Rvb = 1 to 1.3 No_unit)
Invivo PROTAC activity at CRBN/MDM2 in human RS4-11 cells xenografted in mouse assessed as fold change in p53 protein level in tumor at 25 mg/kg, iv administered as single dose and measured after 3 hrs by Western blot analysis (Rvb = 1 to 1.3 No_unit)
Invivo PROTAC activity at CRBN/MDM2 in human RS4-11 cells xenografted in mouse assessed as fold change in MDM2 protein level in tumor at 25 mg/kg, iv administered as single dose and measured after 24 hrs by Western blot analysis (Rvb = 1 No_unit)
Invivo PROTAC activity at CRBN/MDM2 in human RS4-11 cells xenografted in mouse assessed as fold change in MDM2 protein level in tumor at 25 mg/kg, iv administered as single dose and measured after 6 hrs by Western blot analysis (Rvb = 1 No_unit)
Invivo PROTAC activity at CRBN/MDM2 in human RS4-11 cells xenografted in mouse assessed as fold change in MDM2 protein level in tumor at 25 mg/kg, iv administered as single dose and measured after 3 hrs by Western blot analysis (Rvb = 1 No_unit)
PROTAC activity at CRBN/MDM2 in human MV4-11 cells assessed as upregulation of TP53 mRNA expression at 0.1 to 0.3 uM incubated for 6 hrs by qRT-PCR analysis
Assay data:2 Tested
PROTAC activity at CRBN/MDM2 in human MV4-11 cells assessed as upregulation of PUMA mRNA expression at 0.1 to 0.3 uM incubated for 6 hrs by qRT-PCR analysis
Assay data:2 Active, 2 Tested
PROTAC activity at CRBN/MDM2 in human MV4-11 cells assessed as upregulation of p21 mRNA expression at 0.1 to 0.3 uM incubated for 6 hrs by qRT-PCR analysis
PROTAC activity at CRBN/MDM2 in human MV4-11 cells assessed as upregulation of MDM2 mRNA expression at 0.1 to 0.3 uM incubated for 6 hrs by qRT-PCR analysis
PROTAC activity at CRBN/MDM2 in human MV4-11 cells assessed as upregulation of p53 mRNA expression at 0.1 to 0.3 uM incubated for 6 hrs by qRT-PCR analysis
Inhibition of MDM2 in human MV4-11 cells assessed as upregulation of TP53 mRNA expression at 0.1 to 0.3 uM incubated for 6 hrs by qRT-PCR analysis
Inhibition of MDM2 in human MV4-11 cells assessed as upregulation of PUMA mRNA expression at 0.1 to 0.3 uM incubated for 6 hrs by qRT-PCR analysis
Assay data:1 Active, 1 Tested
Inhibition of MDM2 in human MV4-11 cells assessed as upregulation of p21 mRNA expression at 0.1 to 0.3 uM incubated for 6 hrs by qRT-PCR analysis
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