Related BioAssays, by Target Similarity (List) for PubChem BioAssay (S - PubChem BioAssay - NCBI

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Select item 19634871.

In Vitro Test of Activities of Jak1, Jak2, Jak3, Tyk2 Kinases from US Patent US11919896: "[1,2,4]triazolo[1,5-a]pyridine compound as JAK inhibitor and use thereof"

Source:: BindingDB

Protein Targets:: Tyrosine-protein kinase JAK3; ...
Total:: 1

Assay data:14 Active, 1 Activity ≤ 1 µM, 34 Tested

AID:: 1963487

Summary Related BioAssays by Target

Select item 19634862.

In Vitro Test of Activities of Jak1, Jak2, Jak3, Tyk2 Kinases from US Patent US11919896: "[1,2,4]triazolo[1,5-a]pyridine compound as JAK inhibitor and use thereof"

Source:: BindingDB

Protein Targets:: Tyrosine-protein kinase JAK2; ...
Total:: 1

Assay data:34 Active, 22 Activity ≤ 1 µM, 34 Tested

AID:: 1963486

Summary Related BioAssays by Target

Select item 19634853.

In Vitro Test of Activities of Jak1, Jak2, Jak3, Tyk2 Kinases from US Patent US11919896: "[1,2,4]triazolo[1,5-a]pyridine compound as JAK inhibitor and use thereof"

Source:: BindingDB

Protein Targets:: Tyrosine-protein kinase JAK1; ...
Total:: 1

Assay data:34 Active, 34 Activity ≤ 1 µM, 34 Tested

AID:: 1963485

Summary Related BioAssays by Target

Select item 19634844.

In Vitro Test of Activities of Jak1, Jak2, Jak3, Tyk2 Kinases from US Patent US11919896: "[1,2,4]triazolo[1,5-a]pyridine compound as JAK inhibitor and use thereof"

Source:: BindingDB

Protein Targets:: Non-receptor tyrosine-protein kinase TYK2; ...
Total:: 1

Assay data:33 Active, 28 Activity ≤ 1 µM, 34 Tested

AID:: 1963484

Summary Related BioAssays by Target

Select item 19634815.

In Vitro JAK Kinase Assay from US Patent US11918581: "Combination therapy comprising JAK pathway inhibitor and rock inhibitor"

Source:: BindingDB

Protein Targets:: Tyrosine-protein kinase JAK1; ...
Total:: 1

Assay data:26 Active, 26 Activity ≤ 1 µM, 26 Tested

AID:: 1963481

Summary Related BioAssays by Target

Select item 19634136.

TBD from US Patent US20240059694: "COMPOUND CONTAINING 1,3-BENZODIOXOL STRUCTURE AND PREPARATION METHOD AND USE THEREOF"

Source:: BindingDB

Protein Targets:: Tyrosine-protein kinase JAK3; ...
Total:: 1

Assay data:28 Active, 30 Activity ≤ 1 µM, 30 Tested

AID:: 1963413

Summary Related BioAssays by Target

Select item 19634037.

In Vitro JAK Kinase Assay from US Patent US20240058343: "TREATMENT OF URTICARIA USING JAK INHIBITORS"

Source:: BindingDB

Protein Targets:: Tyrosine-protein kinase JAK1; ...
Total:: 1

Assay data:26 Active, 26 Activity ≤ 1 µM, 26 Tested

AID:: 1963403

Summary Related BioAssays by Target

Select item 19631228.

NanoBRET assay (JAK2, SGC Frankfurt)

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase JAK2

Assay data:2 Tested

AID:: 1963122

Summary Related BioAssays by Target

Select item 19631219.

NanoBRET assay (JAK1, SGC Frankfurt)

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase JAK1

Assay data:2 Tested

AID:: 1963121

Summary Related BioAssays by Target

Select item 196086810.

Inhibition of JAK3 (unknown origin) at 10 uM by biochemical hotspot kinase assay

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase JAK3

Assay data:1 Tested

AID:: 1960868

Summary Related BioAssays by Target

Select item 195916511.

Inhibition of JAK2 (unknown origin) at 1000 nM by by DiscoverX KINOMEscan assay

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase JAK2

Assay data:1 Active, 1 Tested

AID:: 1959165

Summary Related BioAssays by Target

Select item 195916112.

Inhibition of JAK2 (unknown origin) at 1000 nM by by DiscoverX KINOMEscan assay relative to control

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase JAK2

Assay data:1 Tested

AID:: 1959161

Summary Related BioAssays by Target

Select item 195912513.

Inhibition of JAK3 (unknown origin) at 1000 nM by by DiscoverX KINOMEscan assay relative to control

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase JAK3

Assay data:1 Tested

AID:: 1959125

Summary Related BioAssays by Target

Select item 195878714.

Inhibition of JAK3 (unknown origin)

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase JAK3

Assay data:10 Activity ≤ 1 µM, 10 Tested

AID:: 1958787

Summary Related BioAssays by Target

Select item 195878615.

Inhibition of JAK2 (unknown origin)

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase JAK2

Assay data:10 Activity ≤ 1 µM, 10 Tested

AID:: 1958786

Summary Related BioAssays by Target

Select item 195836816.

Inhibition of JAK1 (unknown origin) at 1 uM relative to control

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase JAK1

Assay data:3 Tested

AID:: 1958368

Summary Related BioAssays by Target

Select item 195668817.

Inhibition of human JAK3 assessed as residual activity at 1 uM relative to control

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase JAK3

Assay data:1 Tested

AID:: 1956688

Summary Related BioAssays by Target

Select item 195593418.

Inhibition of TYK2 (unknown origin) at 1 uM relative to control

Source:: ChEMBL

Protein Target:: Non-receptor tyrosine-protein kinase TYK2

Assay data:1 Tested

AID:: 1955934

Summary Related BioAssays by Target

Select item 195592819.

Inhibition of JAK3 (unknown origin) at 1 uM relative to control

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase JAK3

Assay data:1 Tested

AID:: 1955928

Summary Related BioAssays by Target

Select item 195591820.

Inhibition of JAK1 (unknown origin) at 1 uM relative to control

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase JAK1

Assay data:1 Tested

AID:: 1955918

Summary Related BioAssays by Target

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Target

Proteins (14)
BioAssays with protein sequences specified as targets

BioActivity

Active Compounds (1,987)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (384)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (1,672)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (2,230)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (3)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose

Assay Project (7)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (3,584)
BioAssays extracted from the literature
NIH MLP (8)
BioAssays deposited by the NIH Molecular Libraries Program
Other (182)
BioAssays deposited by other experimentalists

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PubChem BioAssay
Arf1 ADP-ribosylation factor 1 [Rattus norvegicus]
Arf1 ADP-ribosylation factor 1 [Rattus norvegicus]
Gene ID:64310

Gene
Gene Links for GEO Profiles (Select 31043008) (1)
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