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BRAF SGC Tm panel (DSF)
Assay data:1 Tested
SummaryRelated BioAssays by Target
RAF1 Invitrogen Lab (UK) kinase screen (BI)
Inhibition of c-RAF (unknown origin) at 10 uM by biochemical hotspot kinase assay relative to control
Inhibition of B-RAF (unknown origin) at 10 uM by biochemical hotspot kinase assay relative to control
Protac activity at E3 ubiquitin ligase/BRAF in human EA.hy 926 cells assessed as degradation of BRAF protein at 30 uM preincubated with S5 for 2 hrs followed by compound addition and measured after 48 hrs by Western blot analysis
Protac activity at E3 ubiquitin ligase/BRAF in human EA.hy 926 cells assessed as degradation of BRAF protein at 30 uM preincubated with VH032 for 2 hrs followed by compound addition and measured after 48 hrs by Western blot analysis
Protac activity at E3 ubiquitin ligase/BRAF in human MDA-MB-231 cells assessed as degradation of BRAF protein
Protac activity at E3 ubiquitin ligase/BRAF in human U87 cells assessed as degradation of BRAF protein
Assay data:1 Active, 1 Tested
Protac activity at E3 ubiquitin ligase/BRAF in human HepG2 cells assessed as degradation of BRAF protein
Protac activity at E3 ubiquitin ligase/BRAF in human EA.hy 926 cells assessed as degradation of BRAF protein at 40 uM incubated for 4 to 48 hrs by western blot assay
Protac activity at E3 ubiquitin ligase/BRAF in human EA.hy 926 cells assessed as degradation of BRAF protein at 40 uM incubated for 48 hrs by western blot assay
Protac activity at E3 ubiquitin ligase/BRAF in human EA.hy 926 cells assessed as degradation of BRAF protein at 40 uM incubated for 4 hrs by western blot assay
Protac activity at E3 ubiquitin ligase/BRAF in human EA.hy 926 cells assessed as degradation of BRAF protein at 10 to 60 uM incubated for 48 hrs by western blot assay
Assay data:2 Active, 3 Tested
Inhibition of B-RAF (unknown origin) at 10 uM using magnesium acetate as substrate incubated for 40 mins in presence of [gamma33P]ATP by scintillation counting based hotspot kinase assay relative to control
Assay data:4 Tested
Inhibition of B-RAF (unknown origin) using magnesium acetate as substrate incubated for 40 mins in presence of [gamma33P]ATP by scintillation counting based hotspot kinase assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of B-RAF V600E mutant (unknown origin) at 10 uM using magnesium acetate as substrate incubated for 40 mins in presence of [gamma33P]ATP by scintillation counting based hotspot kinase assay relative to control
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