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hFAAH Endocannabinoid related and lipase panel
Assay data:1 Active, 1 Tested
SummaryRelated BioAssays by Target
Inhibition of mouse brain FAAH
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of FAAH in mouse Primary neuron cells using [3H]AEA as substrate at 30 uM incubated for 30 mins by liquid scintillation analysis
Assay data:1 Tested
Inhibition of mouse FAAH expressed in COS-7 cells using [3H]AEA as substrate incubated for 30 mins by liquid scintillation analysis
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Displacement of FP-rhodamine from FAAH in mouse brain membrane fraction preincubated for 30 mins followed by FP-rhodhamine addition for 10 mins by Activity-Based Protein Profiling analysis
Assay data:2 Tested
FAAH Enzyme Inhibition Assay from US Patent US11753371: "Disulfiram derivatives as ALDH1A1 and MAGL inhibitors"
Assay data:1 Active, 1 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
In Vitro Competitive Activity-Based Protein Assay from US Patent US11655217: "Pyrazole MAGL inhibitors"
Assay data:252 Active, 249 Activity ≤ 1 µM, 252 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Displacement of [14C]-ethanolamine from FAAH derived from rat brain membrane fraction preincubated for 20 mins followed by susbstrate addition by scintillation counting method
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Selectivity interaction (HERG functional (IKr) voltage clamp assay) EUB0000306b FAAH
Affinity Biochemical interaction (Binding assay) EUB0000540a FAAH
Affinity Biochemical interaction (Glutamate dehydrogenase-coupled FAAH assay (preincubation time 60 min)) EUB0000306b FAAH
Inhibition of FAAH in mouse brain membrane at 10 uM using TAMRA-FP serine hydrolase probe as substrate preincubated for 25 mins followed by substrate addition and measured after 25 mins SDS-PAGE analysis
Assay data:2 Active, 3 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human recombinant FAAH using AMC arachidonoyl amide as substrate incubated for 30 mins by fluorescence based assay
Assay data:2 Active, 14 Tested
Inhibition of FAAH in rat eye homogenate assessed as blockage of TGAMRA-FP labelling by ABPP assay
Assay data:2 Active, 2 Tested
Inhibition of recombinant human FAAH assessed as blockage of TGAMRA-FP labelling at 100 uM by ABPP assay
Assay data:1 Active, 2 Tested
Reversible inhibition of human recombinant FAAH preincubated with compound for 15 mins followed by substrate addition and measured after 1 hr by fluorescence based dilution method
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of recombinant FAAH (unknown origin) expressed in COS7 cells assessed as blockade of substrate hydrolysis using 2-AG as substrate preincubated with compound for 30 mins followed by substrate addition
Inhibition of mouse brain FAAH by competitive ABPP assay
Inhibition of FAAH (unknown origin) by fluorescence based method
Assay data:10 Active, 8 Activity ≤ 1 µM, 10 Tested
Non-competitive inhibition of FAAH (unknown origin) using arachidonoyl as substrate by Dixon plot analysis
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