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Inhibition Assay from Article 10.1016/S1074-5521(01)00034-5: "Structure-based design and in-parallel synthesis of inhibitors of AmpC beta-lactamase."
Assay data:33 Active, 17 Activity ≤ 1 µM, 41 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Enzyme Inhibition Assay from Article 10.1016/S1074-5521(00)00052-1: "Energetic, structural, and antimicrobial analyses of beta-lactam side chain recognition by beta-lactamases."
Assay data:11 Active, 10 Activity ≤ 1 µM, 14 Tested
Inhibition of penicillinase in Staphylococcus aureus 01A400 assessed as potentiation of benzylpenicillin-induced antibacterial activity by measuring benzylpenicillin MIC at 3.12 ug/ml (Rvb = 200 ug/ml)
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of beta-lactamase in Staphylococcus aureus ATCC 25923 assessed as potentiation of amoxicillin induced antibacterial activity after 24 hrs by agar well diffusion method
Assay data:2 Tested
Inhibition of beta-lactamase in Staphylococcus aureus ATCC 25923 assessed as potentiation of amoxicillin induced antibacterial activity by measuring amoxicillin MIC after 24 hrs by agar well diffusion method (Rvb = 1.5 ug/ml)
Inhibition of beta-lactamase in Staphylococcus aureus ATCC 25923 assessed as potentiation of amoxicillin induced antibacterial activity at 5% amoxicillin to compound dilution after 24 hrs by agar well diffusion method
Inhibition of beta-lactamase in Staphylococcus aureus ATCC 25923 assessed as potentiation of amoxicillin induced antibacterial activity at 10 to 100% amoxicillin to compound dilution after 24 hrs by agar well diffusion method
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of methicillin-resistant Staphylococcus aureus beta-lactamase up to 32 ug/ml by nitrocefin assay
Activity of Staphylococcus aureus betalactamase PC1 assessed as drug hydrolysis by spectrophotometry relative to cephaloridine
Assay data:4 Tested
Activity of Staphylococcus aureus betalactamase PC1 assessed as drug hydrolysis by spectrophotometry
Assay data:1 Active, 5 Tested
Ratio of Kcat to Km of Staphylococcus aureus betalactamase PC1 assessed as drug hydrolysis by spectrophotometry
Assay data:5 Tested
Ratio of Kcat to Km of Staphylococcus aureus betalactamase PC1 assessed as drug hydrolysis by spectrophotometry relative to cephaloridine
Inhibition of Staphylococcus aureus Russell beta-lactamase assessed as inhibition of nitrocefin hydrolysis up to 567 ug/ml pre-incubated for 5 mins by microtiter plate assay
Inhibition of Staphylococcus aureus Russell beta-lactamase assessed as inhibition of nitrocefin hydrolysis pre-incubated for 5 mins by microtiter plate assay
Binding affinity to class A beta lactamase of Staphylococcus aureus PC1
Steady state kinetic as limiting rate of Staphylococcus aureus PC1 Beta-lactamase hydrolysis
Km for Staphylococcus aureus PC1 Beta-lactamase hydrolysis
Assay data:4 Active, 2 Activity ≤ 1 µM, 5 Tested
Beta-lactamase inhibitory activity against penicillinase of Staphylococcus aureus 1840
Inhibitory activity against Staphylococcus aureus penicillinase
Assay data:1 Active, 1 Activity ≤ 1 µM, 11 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
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