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Inhibition of MBI-D-resistant Magnaporthe oryzae SW (OYU-1) scytalone dehydratase Val75Met mutant assessed as metabolism ratio of scytalone at 75 nM at 30 degC in presence of 50 mM PIPES
Assay data:45 Tested
SummaryRelated BioAssays by Target
Inhibition of wild type Magnaporthe oryzae Hoku-1 scytalone dehydratase assessed as metabolism ratio of scytalone at 75 nM at 30 degC in presence of 50 mM PIPES
Inhibition of Magnaporthe grisea scytalone dehydratase
Assay data:27 Active, 19 Activity ≤ 1 nM, 27 Activity ≤ 1 µM, 27 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB
Assay data:3598 Active, 421 Activity ≤ 1 nM, 2233 Activity ≤ 1 µM, 3598 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Compound was evaluated for its inhibition constant against scytalone dehydratase (SD)
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
The inhibitory activity (Ki) of the protonated compound was measured against scytalone dehydratase at pH 7.0
Assay data:3 Active, 1 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
The inhibitory activity (Ki) of the deprotonated compound was measured against scytalone dehydratase at pH 9.8
Assay data:3 Active, 2 Activity ≤ 1 µM, 4 Tested
The compound was evaluated for its relative binding affinity against wild type scytalone dehydratase (SD);Relative Ki
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
The compound was evaluated for its relative binding affinity against mutant Y50F scytalone dehydratase; Relative Ki
The compound was evaluated for its relative binding affinity against mutant Y30F scytalone dehydratase; Relative Ki
The compound was evaluated for its relative binding affinity against mutant N131A scytalone dehydratase; Relative Ki
The compound was evaluated for its relative binding affinity against mutant H85N scytalone dehydratase; Relative Ki
The compound was evaluated for its relative binding affinity against mutant H110N scytalone dehydratase; Relative Ki
The compound was evaluated for its binding affinity against wild type scytalone dehydratase (SD)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
The compound was evaluated for its binding affinity against mutant Y50F scytalone dehydratase
The compound was evaluated for its binding affinity against mutant Y30F scytalone dehydratase
The compound was evaluated for its binding affinity against mutant N131A scytalone dehydratase
The compound was evaluated for its binding affinity against mutant H85N scytalone dehydratase
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
The compound was evaluated for its binding affinity against mutant H110N scytalone dehydratase
Inhibition of scytalone dehydratase purified from Magnaporthe grisea
Assay data:19 Active, 17 Activity ≤ 1 nM, 19 Activity ≤ 1 µM, 19 Tested
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