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Inhibition of human recombinant CA5B assessed as inhibition constant pre-incubated for 15 mins measured by phenol red dye based stopped flow CO2 hydration assay
Assay data:8 Active, 8 Activity ≤ 1 µM, 17 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human recombinant CA5A assessed as inhibition constant pre-incubated for 15 mins measured by phenol red dye based stopped flow CO2 hydration assay
Assay data:8 Active, 7 Activity ≤ 1 µM, 17 Tested
Binding affinity to human recombinant CA5A assessed as inhibition constant incubated for 15 mins prior to testing by phenol red based stopped-flow CO2 hydration assay
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Carbonic Anhydrase Eurofins-Panlabs enzyme assay
Assay data:1 Tested
SummaryRelated BioAssays by Target
Activation of human carbonic anhydrase 5B by stopped flow assay
Assay data:6 Active, 2 Activity ≤ 1 µM, 6 Tested
Activation of human carbonic anhydrase 5A by stopped flow assay
Assay data:6 Active, 2 Activity ≤ 1 µM, 7 Tested
Inhibition of human carbonic anhydrase 5B by stopped-flow CO2 hydration assay
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
Inhibition of human carbonic anhydrase 5A by stopped-flow CO2 hydration assay
Assay data:6 Active, 4 Activity ≤ 1 µM, 6 Tested
CA Inhibition Assay from Article 10.3109/14756366.2013.804072: "Inhibition of mammalian carbonic anhydrases I-XIV with grayanotoxin III: solution and in silico studies."
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
CA Inhibition Assay from Article 10.3109/14756366.2011.650692: "Metronidazole-coumarin conjugates and 3-cyano-7-hydroxy-coumarin act as isoform-selective carbonic anhydrase inhibitors."
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Inhibition Assay from Article 10.1111/j.1747-0285.2009.00857.x: "Which carbonic anhydrases are targeted by the antiepileptic sulfonamides and sulfamates?"
Assay data:5 Active, 2 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 5 Tested
CA Inhibition Assay from Article 10.1016/j.bmc.2009.06.006: "Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inhibitors of human mitochondrial isoforms VA and VB."
Assay data:17 Active, 17 Activity ≤ 1 µM, 17 Tested
CA Inhibition Assay from Article 10.1021/jm900641r: "Carbonic anhydrase inhibitors. Comparison of aliphatic sulfamate/bis-sulfamate adducts with isozymes II and IX as a platform for designing tight-binding, more isoform-selective inhibitors."
Assay data:6 Active, 1 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 6 Tested
CA Inhibition Assay from Article 10.1016/j.bmc.2008.12.023: "Carbonic anhydrase inhibitors. Comparison of chlorthalidone, indapamide, trichloromethiazide, and furosemide X-ray crystal structures in adducts with isozyme II, when several water molecules make the difference."
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
CA Inhibition Assay from Article 10.1016/j.bmc.2008.06.013: "Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid."
Assay data:10 Active, 3 Activity ≤ 1 µM, 11 Tested
CA Inhibition Assay from Article 10.1016/j.bmc.2008.09.032: "Carbonic anhydrase inhibitors: synthesis and inhibition studies against mammalian isoforms I-XV with a series of 2-(hydrazinocarbonyl)-3-substituted-phenyl-1H-indole-5-sulfonamides."
Assay data:15 Active, 15 Activity ≤ 1 µM, 15 Tested
CA Inhibition Assay from Article 10.1016/j.bmcl.2008.03.051: "Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct."
Assay data:13 Active, 1 Activity ≤ 1 nM, 12 Activity ≤ 1 µM, 13 Tested
CA Inhibition Assay from Article 10.1016/j.bmcl.2008.06.105: "Carbonic anhydrase inhibitors. Interaction of the antitumor sulfamate EMD 486019 with twelve mammalian carbonic anhydrase isoforms: Kinetic and X-ray crystallographic studies."
Assay data:4 Active, 1 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
CA Inhibition Assay from Article 10.1021/jm060807n: "Carbonic anhydrase inhibitors: clash with Ala65 as a means for designing inhibitors with low affinity for the ubiquitous isozyme II, exemplified by the crystal structure of the topiramate sulfamide analogue."
Assay data:9 Active, 2 Activity ≤ 1 nM, 9 Activity ≤ 1 µM, 9 Tested
CA Inhibition Assay from Article 10.1021/jm050483n: "Carbonic anhydrase inhibitors. The mitochondrial isozyme VB as a new target for sulfonamide and sulfamate inhibitors."
Assay data:34 Active, 34 Activity ≤ 1 µM, 34 Tested
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