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In Vitro Radioligand Binding Assay from US Patent US20240000767: "COMBINATION OF AN ALPHA2-ADRENOCEPTOR SUBTYPE C (ALPHA-2C) ANTAGONIST WITH A TASK1/3 CHANNEL BLOCKER FOR THE TREATMENT OF SLEEP APNEA"
Assay data:126 Active, 20 Activity ≤ 1 nM, 118 Activity ≤ 1 µM, 126 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
SPR Assay from US Patent US11786528: "Pyrazolopyrimidine compounds as adenosine receptor antagonists"
Assay data:46 Active, 46 Activity ≤ 1 µM, 46 Tested
Binding affinity to alpha2C AR (unknown origin) assessed as inhibition constant
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Selectivity interaction (Enzyme panel (GPCRS, ion channels, and transporters)) EUB0000194b ADRA2C
Assay data:1 Tested
SummaryRelated BioAssays by Target
Selectivity interaction (GPCR panel (PDSP screen)) EUB0000548a ADRA2C
Selectivity interaction (GPCR panel (PDSP screen)) EUB0000309b ADRA2B
Selectivity interaction (CEREP panel (Eurofins, enzymes and uptake assays)) EUB0000544a ADRA2B
Selectivity interaction (CEREP panel (Eurofins, binding assay)) EUB0000544a ADRA2B
Selectivity interaction (NIMH Psychoactive Drug Screening Program Selectivity Panel (radioligand binding assay)) EUB0000214b ADRA2C
Selectivity interaction (GPCR panel (PDSP screen)) EUB0000540a ADRA2C
Selectivity interaction (GPCR panel (PDSP screen)) EUB0000306b ADRA2C
Selectivity interaction (GPCR panel (PDSP screen)) EUB0000300bCl ADRA2B
Selectivity interaction (GPCR panel (PDSP screen)) EUB0000337aCl ADRA2B
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Selectivity interaction (GPCR panel (PDSP screen)) EUB0000289bCl ADRA2C
Selectivity interaction (GPCR panel (PDSP screen)) EUB0000289bCl ADRA2B
Selectivity interaction (GPCR panel (PDSP screen)) EUB0000316b ADRA2C
Selectivity interaction (GPCR panel (PDSP screen)) EUB0000316b ADRA2B
Selectivity interaction (Radioligand binding assay (MDS Pharma Service)) EUB0000296b ADRA2C
Selectivity interaction (GPCR panel (PDSP screen)) EUB0000327a ADRA2A
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