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Evaluation of ABHD6 Enzyme Inhibitory Activity Assay from US Patent US20240010658: "ABHD6 ANTAGONIST"
Assay data:20 Active, 14 Activity ≤ 1 nM, 20 Activity ≤ 1 µM, 20 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of ABHD6 in mouse brain membrane at 10 uM using TAMRA-FP serine hydrolase probe as substrate preincubated for 25 mins followed by substrate addition and measured after 25 mins SDS-PAGE analysis
Assay data:3 Active, 4 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
In Vitro Competitive Activity-Based Protein Profiling Assay from US Patent US10781211: "Spirocycle compounds and methods of making and using same"
Assay data:195 Active, 196 Activity ≤ 1 µM, 196 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Fluorescent Assay from US Patent US10662159: "ABHD6 and dual ABHD6/MGL inhibitors and their uses"
Assay data:50 Active, 60 Activity ≤ 1 µM, 60 Tested
Serine Hydrolase Activity Assay from Article 10.1021/ja062999h: "The putative endocannabinoid transport blocker LY2183240 is a potent inhibitor of FAAH and several other brain serine hydrolases."
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of human ABHD6 transfected in HEK293 cells using 2-OG as substrate preincubated for 30 mins followed by substrate addition measured after 5 mins by liquid scintillation spectroscopy
Assay data:3 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human ABHD6 expressed in Expi293 cells using p-nitrophenyl acetate as substrate incubated for 30 mins by spectrophotometry
Assay data:1 Tested
Inhibition of human ABHD6 expressed in HEK293 cells using [3H]2-OG as substrate at 10 uM preincubated for 30 mins followed by substrate addition and measured after 5 mins by liquid scintillation spectroscopy
Assay data:4 Tested
Inhibition of ABHD6 in mouse brain membrane up to 30 uM preincubated for 25 mins followed by TAMRA-FP labeling addition and measured after 5 mins by competitive ABPP based analysis
Inhibition of human ABHD6 expressed in HEK293 cells using [3H]2-OG as substrate preincubated for 30 mins followed by substrate addition and measured after 5 mins by liquid scintillation spectroscopy
Inhibition of human ABHD6 expressed in HEK293 cells using 2-OG as substrate preincubated for 30 mins followed by substrate addition and measured after 5 mins by liquid scintillation spectroscopy
Assay data:2 Active, 2 Activity ≤ 1 µM, 14 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of FP-Rh binding to ABHD6 in mouse brain cytosolic fraction preincubated for 1 hr followed by FP-Rh addition and measured after 1 hr by SDS-PAGE analysis
Assay data:1 Active, 3 Tested
Inhibition of mouse brain membrane ABHD6 assessed as enzyme remaining activity at 10 uM preincubated for 30 mins followed by MB064 or FP-TAMRA addition and measured after 15 mins by SDS-PAGE based ABPP analysis relative to control
Inhibition of ABHD6 in mouse brain membrane assessed as protein band intensity at 1.56 uM pre-incubated for 25 mins followed by TAMRA-FP probe labeling for 5 mins by SDS-PAGE analysis relative to control
Inhibition of ABHD6 in mouse brain membrane assessed as protein band intensity at 6.25 uM pre-incubated for 25 mins followed by TAMRA-FP probe labeling for 5 mins by SDS-PAGE analysis relative to control
Inhibition of ABHD6 in mouse brain membrane assessed as protein band intensity at 12.5 uM pre-incubated for 25 mins followed by TAMRA-FP probe labeling for 5 mins by SDS-PAGE analysis relative to control
Inhibition of ABHD6 in mouse brain membrane assessed as protein band intensity at 25 uM pre-incubated for 25 mins followed by TAMRA-FP probe labeling for 5 mins by SDS-PAGE analysis relative to control
Inhibition of ABHD6 in mouse brain membrane assessed as protein band intensity at 50 uM pre-incubated for 25 mins followed by TAMRA-FP probe labeling for 5 mins by SDS-PAGE analysis relative to control
Inhibition of ABHD6 in mouse brain membrane assessed as protein band intensity at 10 uM pre-incubated for 25 mins followed by TAMRA-FP probe labeling for 5 mins by SDS-PAGE analysis relative to control
Inhibition of ABHD6 in mouse brain membrane assessed as protein band intensity at 1 uM pre-incubated for 25 mins followed by TAMRA-FP probe labeling for 5 mins by SDS-PAGE analysis relative to control
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