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Evaluation of ABHD6 Enzyme Inhibitory Activity Assay from US Patent US20240010658: "ABHD6 ANTAGONIST"
Assay data:20 Active, 14 Activity ≤ 1 nM, 20 Activity ≤ 1 µM, 20 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of ABHD6 in mouse brain membrane at 10 uM using TAMRA-FP serine hydrolase probe as substrate preincubated for 25 mins followed by substrate addition and measured after 25 mins SDS-PAGE analysis
Assay data:3 Active, 4 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
In Vitro Competitive Activity-Based Protein Profiling Assay from US Patent US10781211: "Spirocycle compounds and methods of making and using same"
Assay data:195 Active, 196 Activity ≤ 1 µM, 196 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Fluorescent Assay from US Patent US10662159: "ABHD6 and dual ABHD6/MGL inhibitors and their uses"
Assay data:50 Active, 60 Activity ≤ 1 µM, 60 Tested
In Vitro Inhibition of DAGL from US Patent US10583137: "Triazole DAGLα inhibitors"
Assay data:56 Active, 34 Activity ≤ 1 µM, 56 Tested
Serine Hydrolase Activity Assay from Article 10.1021/ja062999h: "The putative endocannabinoid transport blocker LY2183240 is a potent inhibitor of FAAH and several other brain serine hydrolases."
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of human ABHD6 transfected in HEK293 cells using 2-OG as substrate preincubated for 30 mins followed by substrate addition measured after 5 mins by liquid scintillation spectroscopy
Assay data:3 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human ABHD6 expressed in Expi293 cells using p-nitrophenyl acetate as substrate incubated for 30 mins by spectrophotometry
Assay data:1 Tested
Inhibition of human ABHD6 expressed in HEK293 cells using [3H]2-OG as substrate at 10 uM preincubated for 30 mins followed by substrate addition and measured after 5 mins by liquid scintillation spectroscopy
Assay data:4 Tested
Inhibition of ABHD6 in mouse brain membrane up to 30 uM preincubated for 25 mins followed by TAMRA-FP labeling addition and measured after 5 mins by competitive ABPP based analysis
Inhibition of human ABHD6 expressed in HEK293 cells using [3H]2-OG as substrate preincubated for 30 mins followed by substrate addition and measured after 5 mins by liquid scintillation spectroscopy
Inhibition of human ABHD6 expressed in HEK293 cells using 2-OG as substrate preincubated for 30 mins followed by substrate addition and measured after 5 mins by liquid scintillation spectroscopy
Assay data:2 Active, 2 Activity ≤ 1 µM, 14 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of FP-Rh binding to ABHD6 in mouse brain cytosolic fraction preincubated for 1 hr followed by FP-Rh addition and measured after 1 hr by SDS-PAGE analysis
Assay data:1 Active, 3 Tested
Inhibition of mouse brain membrane ABHD6 assessed as enzyme remaining activity at 10 uM preincubated for 30 mins followed by MB064 or FP-TAMRA addition and measured after 15 mins by SDS-PAGE based ABPP analysis relative to control
Inhibition of mouse brain membrane DAGLbeta assessed as enzyme remaining activity at 10 uM preincubated for 30 mins followed by MB064 or FP-TAMRA addition and measured after 15 mins by SDS-PAGE based ABPP analysis relative to control
Inhibition of mouse DAGLbeta expressed in HEK293T cell membranes using SAG as substrate preincubated for 30 mins followed by substrate addition by enzyme coupled natural substrate assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of V-tagged mouse DAGLbeta expressed in HEK2934T cell membrane fractions using SAG as substrate assessed as accumulation of 2-AG preincubated for 30 mins followed by probe addition measured after 30 mins by LC-MS natural substrate assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition mouse DAGLbeta expressed in HEK293T cell membrane fractions using DAG as substrate preincubated for 30 mins followed by ABP HT01 probe addition measured after 30 mins in presence of probe by gel-based ABPP competition assay
Assay data:5 Active, 4 Activity ≤ 1 µM, 5 Tested
Inhibition of full length 3' FLAG-tagged mouse DAGLbeta expressed in African green monkey COS7 cells using sn-1-stearoyl-[14C]-arachidonoyl-glycerol as substrate preincubated for 15 mins followed by substrate addition measured after 30 mins by radiometric natural substrate assay
Inhibition of human GST-tagged DAGLbeta catalytic domain expressed in HEK293F cell membranes using EnzChek as substrate preincubated for 5 mins followed by substrate addition by fluorogenic surrogate substrate assay
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