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Inhibition of PLD2 (unknown origin) expressed in human HEK cells by immunoprecipitation
Assay data:14 Active, 7 Activity ≤ 1 µM, 25 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Cell-Based Assay from US Patent US9453017: "Antiviral therapies with phospholipase D inhibitors"
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
In Vitro Activity Assay from US Patent US9453017: "Antiviral therapies with phospholipase D inhibitors"
In vitro Exogenous Substrate Assay from Article 10.1021/cb500828m: "Discovery of desketoraloxifene analogues as inhibitors of mammalian, Pseudomonas aeruginosa, and NAPE phospholipase D enzymes."
Assay data:10 Active, 13 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
In vivo Deuterated 1-Butanol PLD Assay from Article 10.1021/cb500828m: "Discovery of desketoraloxifene analogues as inhibitors of mammalian, Pseudomonas aeruginosa, and NAPE phospholipase D enzymes."
Assay data:9 Active, 5 Activity ≤ 1 µM, 9 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
PLD In Vitro Kinetic Assay from Article 10.1111/cbdd.12319: "1,3-disubstituted-4-aminopyrazolo [3, 4-d] pyrimidines, a new class of potent inhibitors for phospholipase D."
Assay data:23 Active, 21 Activity ≤ 1 µM, 23 Tested
Inhibition of GFP-fused PLD2 (unknown origin) expressed in HEK293 cells by cellular assay
Assay data:17 Active, 14 Activity ≤ 1 µM, 17 Tested
Inhibition of PLD2 (unknown origin)
Assay data:6 Active, 5 Activity ≤ 1 µM, 6 Tested
Human PLD2 (Hydrolases)
Assay data:6 Active, 6 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Human PLD1 (Phosphatidylcholine-specific phospholipase D)
Assay data:2 Active, 2 Tested
Identifying inhibitors with PLD2 specific Cellular Isoenzyme Activity
Assay data:23 Active, 80 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
PLD2 Cellular Concentration Response Study
Assay data:21 Active, 14 Activity ≤ 1 µM, 21 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Discovery of PLD2 inhibitors using the Purified Enzyme Concentration Response Assay
Assay data:3 Active, 1 Activity ≤ 1 µM, 3 Tested
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of GFP-tagged PLD2 in human HEK293 cells assessed as deuterated 1-butanol incorporation pretreated for 5 mins prior to substrate addition measured after 30 mins by mass spectrometry
Assay data:9 Active, 7 Activity ≤ 1 µM, 9 Tested
Inhibition of PLD2 (unknown origin) assessed as release of [methyl-3H] from [choline-methyl-3H] dipalmitoyl-phosphotidylcholine after 30 mins by liquid scintillation counting analysis
Inhibition of PLD2 in human U87MG cells assessed as decrease in cell migration after 48 hrs by transwell invasion assay
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of GFP-tagged PLD2 in HEK293 cells assessed as deuterated 1-butanol incorporation at 1.5 uM pretreated for 5 mins prior to substrate addition measured after 30 mins by mass spectrometry
Assay data:1 Active, 1 Tested
PLD2 Cellular isoenzyme activity (PLD2_Assay_1B_Lib32)
Assay data:9 Active, 28 Tested
PLD1 Cellular isoenzyme activity (PLD1_Assay_1A_Lib32)
Assay data:10 Active, 28 Tested
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