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Inhibition of PLD1 (unknown origin) expressed in human HEK cells by immunoprecipitation assay
Assay data:25 Active, 23 Activity ≤ 1 µM, 27 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Cell-Based Assay from US Patent US9453017: "Antiviral therapies with phospholipase D inhibitors"
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
In Vitro Activity Assay from US Patent US9453017: "Antiviral therapies with phospholipase D inhibitors"
Inhibition Assay from US Patent US9127005: "Isoform selective phospholipase D inhibitors"
Assay data:8 Active, 4 Activity ≤ 1 µM, 9 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
In vitro Exogenous Substrate Assay from Article 10.1021/cb500828m: "Discovery of desketoraloxifene analogues as inhibitors of mammalian, Pseudomonas aeruginosa, and NAPE phospholipase D enzymes."
Assay data:10 Active, 13 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
In vivo Deuterated 1-Butanol PLD Assay from Article 10.1021/cb500828m: "Discovery of desketoraloxifene analogues as inhibitors of mammalian, Pseudomonas aeruginosa, and NAPE phospholipase D enzymes."
Assay data:9 Active, 5 Activity ≤ 1 µM, 9 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
PLD In Vitro Kinetic Assay from Article 10.1111/cbdd.12319: "1,3-disubstituted-4-aminopyrazolo [3, 4-d] pyrimidines, a new class of potent inhibitors for phospholipase D."
Assay data:23 Active, 21 Activity ≤ 1 µM, 23 Tested
PLD2 In Vitro Enzymatic Assay from Article 10.1038/nchembio.140: "Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness."
Assay data:23 Active, 13 Activity ≤ 1 µM, 26 Tested
293-PLD2 Cell-Based Assay from Article 10.1038/nchembio.140: "Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness."
Assay data:22 Active, 16 Activity ≤ 1 µM, 26 Tested
Calu-1 Cell-Based Assay from Article 10.1038/nchembio.140: "Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness."
Assay data:26 Active, 1 Activity ≤ 1 nM, 23 Activity ≤ 1 µM, 27 Tested
d.311 Enzymatic Inhibition Assay from Article 10.1038/nchembio.140: "Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness."
Assay data:19 Active, 11 Activity ≤ 1 µM, 27 Tested
PLD1 In Vitro Enzymatic Assay from Article 10.1038/nchembio.140: "Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness."
Assay data:23 Active, 17 Activity ≤ 1 µM, 26 Tested
Inhibition of PLD1 in human Calu1 cells
Assay data:15 Active, 1 Activity ≤ 1 nM, 10 Activity ≤ 1 µM, 17 Tested
Inhibition of PLD1 (unknown origin)
Assay data:4 Active, 3 Activity ≤ 1 µM, 6 Tested
Human PLD1 (Phosphatidylcholine-specific phospholipase D)
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of PLD2 (unknown origin) expressed in HEK293-gfp cells by cell-based assay
Assay data:16 Active, 9 Activity ≤ 1 µM, 16 Tested
Inhibition of PLD1 (unknown origin) expressed in human Calu1 cells by cell-based assay
Assay data:16 Active, 13 Activity ≤ 1 µM, 16 Tested
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of PLD1 in human Calu-1 cells assessed as deuterated 1-butanol incorporation pretreated for 5 mins prior to substrate addition measured after 30 mins by mass spectrometry
Assay data:7 Active, 5 Activity ≤ 1 µM, 9 Tested
Inhibition of PLD1 (unknown origin) assessed as release of [methyl-3H] from [choline-methyl-3H] dipalmitoyl-phosphotidylcholine after 30 mins by liquid scintillation counting analysis
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