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Enzyme Inhibition Assay from US Patent US10654857: "Bicyclic compounds as autotaxin (ATX) and lysophosphatidic acid (LPA) production inhibitors"
Assay data:7 Active, 7 Activity ≤ 1 µM, 7 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition Assay from US Patent US10647719: "Bicyclic compounds as dual ATX/CA inhibitors"
Assay data:5 Active, 1 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Enzyme Inhibition Assay from US Patent US10633384: "Diazaspirocycloalkane and azaspirocycloalkane"
Assay data:113 Active, 7 Activity ≤ 1 nM, 90 Activity ≤ 1 µM, 113 Tested
Enzyme Inhibition Assay from US Patent US9802944: "Bicyclic compounds as autotaxin (ATX) and lysophosphatidic acid (LPA) production inhibitors"
Assay data:34 Active, 34 Activity ≤ 1 µM, 34 Tested
Inhibition Assay from US Patent US9630945: "Autotaxin inhibitors"
Assay data:77 Active, 77 Activity ≤ 1 µM, 80 Tested
Confirmatory qHTS for Inhibitors of ATXN expression
Assay data:939 Active, 132 Activity ≤ 1 µM, 2145 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
CMV-Luciferase Counterscreen for Inhibitors of ATXN expression
Assay data:671 Active, 1 Activity ≤ 1 nM, 138 Activity ≤ 1 µM, 2145 Tested
Primary qHTS for Inhibitors of ATXN expression
Assay data:2593 Active, 3 Activity ≤ 1 nM, 2671 Activity ≤ 1 µM, 361713 Tested
Inhibition of recombinant mouse N-terminal polyHis-tagged ATX-beta (Ser49 to Ile862 residues) expressed in HEK293 cells assessed as reduction in cleavage of LPC into LPA and choline using LPC(16:0) as substrate by Amplex red reagent based fluorescence assay
Assay data:7 Active, 6 Activity ≤ 1 µM, 35 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
Assay data:1940 Active, 33 Activity ≤ 1 nM, 9672 Activity ≤ 1 µM, 397420 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
qHTS for Inhibitors of ATXN expression: Summary
SummaryPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
qHTS for Inhibitors of ATXN expression: Validation
Assay data:73 Active, 17 Activity ≤ 1 µM, 1280 Tested
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