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Inhibition of human FBPase in ICR mouse serum starved primary hepatocytes assessed as glucose lowering effect at 50 to 100 uM
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human FBPase in ICR mouse serum starved primary hepatocytes assessed as glucose lowering effect
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to ABPP-labeled FBPase (unknown origin) at 2 to 8 uM by silver staining based streptavidin blotting
Binding affinity to ABPP-labeled FBPase (unknown origin) by silver staining based streptavidin blotting
Inhibition of human FBPase expressed Escherichia coli BL21 in by malachite green dye based spectrophotometry
Assay data:7 Active, 9 Tested
Spectrophotometrical Assay from US Patent US9273021: "Dibenzofuran derivatives as inhibitors of fructose 1,6-bisphosphatase and methods of use thereof"
Assay data:2 Active, 3 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of human FBPase Y258A mutant
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human FBPase R243A mutant
Inhibition of human FBPase D127A mutant
Inhibition of human FBPase N125A mutant
Inhibition of human FBPase S124A mutant
Inhibition of wild type human FBPase
Inhibition of human wild type FBPase expressed in Escherichia coli BL12 (DE3) by malachite green method
Assay data:31 Active, 23 Activity ≤ 1 µM, 36 Tested
Inhibition of FBPase (unknown origin)
Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested
Inhibition of human liver FBPase expressed in Escherichia coli by spectrophotometric method
Inhibition of human liver FBPase expressed in Escherichia coli BL21(DE3) at 10 uM using FBP as substrate in presence of PGI and G6PDH by spectrophotometric method relative to control
Assay data:89 Tested
Inhibition of FBPase in human HepG2 cells assessed as reduction in glucose level preincubated for 20 hrs followed by starvation for 4 hrs by glucose oxidase method
Inhibition of human liver FBPase expressed in Escherichia coli BL21(DE3) using FBP as substrate in presence of PGI and G6PDH by spectrophotometric method
Assay data:85 Active, 67 Activity ≤ 1 µM, 91 Tested
Covalent binding affinity to FBPase WT (unknown origin) assessed as maximum peak absorption measured upto 45 mins by UV-visible spectroscopy (Rvb = 283 nm)
Covalent inhibition of FBPase WT (unknown origin) measured for 45 mins by UV-visible spectrometry analysis
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