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AR Binding Assay from US Patent US11834458: "Anti-cancer nuclear hormone receptor-targeting compounds"
Assay data:11 Active, 13 Activity ≤ 1 µM, 13 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
BIOLOGICAL ACTIVITY from US Patent US20230382870: "N-AROMATIC AMIDE COMPOUNDS, PREPARATION METHODS AND USES THEREOF"
Assay data:31 Active, 31 Activity ≤ 1 µM, 31 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
AR Binding Assay from US Patent US11826430: "Anti-cancer nuclear hormone receptor-targeting compounds"
Assay data:5 Active, 2 Activity ≤ 1 µM, 6 Tested
Androgen Receptor (AR) Radioligand Binding Assay from US Patent US11787812: "Substituted pyrazolo[4,3-d]pyrimidines and imidazo[5,1 -f][1,2,4]triazines as androgen receptor and phosphodiesterase dual inhibitors"
Assay data:13 Active, 20 Activity ≤ 1 µM, 20 Tested
In Vitro Testing of Androgen Receptor Assay from US Patent US11691960: "2-[thiophen-2-yl)formamido]-N-(phenyl)-2-methylpropanamide derivatives and the use thereof as medicament"
Assay data:4 Active, 4 Activity ≤ 1 µM, 7 Tested
Human Androgen Receptor (hAR) Ligand Binding Domain (LBD) Affinity Assay from US Patent US11648234: "Selective androgen receptor degrader (SARD) ligands and methods of use"
Assay data:50 Active, 32 Activity ≤ 1 µM, 50 Tested
Agonist activity at androgen receptor (unknown origin) transfected in human AIZ-AR reporter cells derived from human 22Rv1 cells assessed as increase in luciferase activity at 100 uM incubated for 24 hrs by luciferase reporter gene assay
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
PROTAC activity at VHL/AR in human LNCaP cells assessed as AR degradation at 100 nM measured in presence of 5 uM MG132 after 16 hrs by western blot analysis
Assay data:1 Tested
PROTAC activity at VHL/AR in human LNCaP cells assessed as AR degradation at 100 nM measured in presence of 10 uM AR ligand after 16 hrs by western blot analysis
PROTAC activity at VHL/AR in human LNCaP cells assessed as AR degradation at 100 nM measured in presence of 10 uM VHL ligand after 16 hrs by western blot analysis
PROTAC activity at VHL/AR in human LNCaP cells assessed as AR degradation at 100 nM measured in presence of 0.5 uM MLN4924 after 16 hrs by western blot analysis
PROTAC activity at VHL/AR in human LNCaP cells assessed as induction of AR degradation measured after 16 hrs by western blot analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
PROTAC activity at VHL/AR in human LNCaP cells assessed as reduction in AR level at 100 nM measured after 6 hrs by western blot analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
PROTAC activity at VHL/AR in human LNCaP cells assessed as induction of AR degradation at 0.01 to 1 uM measured after 16 hrs by western blot analysis
Assay data:3 Active, 3 Tested
PROTAC activity at VHL/AR in human LNCaP cells assessed as induction of AR degradation at 10 uM measured after 16 hrs by western blot analysis relative to control
PROTAC activity at VHL/AR in human LNCaP cells assessed as induction of AR degradation at 1 uM measured after 16 hrs by western blot analysis relative to control
PROTAC activity at VHL/AR in human LNCaP cells assessed as induction of AR degradation at 1 to 10 uM measured after 16 hrs by western blot analysis
Assay data:12 Active, 12 Tested
PROTAC activity at CRBN/AR in human LNCaP cells assessed as induction of AR degradation at 1 to 10 uM measured after 16 hrs by western blot analysis
Assay data:9 Tested
Inhibition of full length human AR stably expressed in human HEK293 cells assessed as luciferase activity incubated for 24 hrs by microplate luminometer luciferase assay
Agonist activity at human AR expressed in CHO-K1 cells
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