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Binding affinity to human TR alpha LBD assessed as change in melting temperature at 10 uM by thermal shift assay
Assay data:6 Tested
SummaryPubMed CitationRelated BioAssays by Target
Agonist activity at human TR beta LBD (202 to 461 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as induction of N-terminal biotinylated coactivator SRC2-3 peptide recruitment by alphascreen assay relative to control
Assay data:9 Tested
Agonist activity at wild type human TR alpha LBD expressed in Escherichia coli BL21 (DE3) assessed as induction of N-terminal biotinylated coactivator SRC2-3 peptide recruitment by alphascreen assay relative to control
Assay data:2 Tested
Binding affinity to human TR beta LBD (202 to 461 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as change in melting temperature at 10 uM in presence of ZnSO4 by thermal shift assay
Assay data:10 Tested
Agonist activity at human TR beta LBD (202 to 461 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as induction of N-terminal biotinylated coactivator SRC2-3 peptide recruitment by alphascreen assay
Assay data:28 Active, 28 Activity ≤ 1 µM, 32 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Agonist activity at wild type human TR alpha LBD expressed in Escherichia coli BL21 (DE3) assessed as induction of N-terminal biotinylated coactivator SRC2-3 peptide recruitment by alphascreen assay
Assay data:21 Active, 20 Activity ≤ 1 µM, 28 Tested
Agonist activity at human THR-beta expressed in CHO-K1 cells by PathHunter assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Agonist activity at human THR-alpha expressed in CHO-K1 cells by PathHunter assay
Agonist activity at human THR-alpha expressed in CHO-K1 cells assessed as maximum relative efficacy at 100 uM by PathHunter assay relative to control
Assay data:1 Tested
Agonist activity at human THR-beta expressed in CHO-K1 cells assessed as maximum relative efficacy at 100 uM by PathHunter assay relative to triiodothyronine ine
THYROID HORM Eurofins SafetyScreen44 (BI)
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Agonist activity at human THbeta (202 to 461 residues) in Cos7 cells transfected with LBD-Gal4 and pGL435 Gal4 UAS Luc reporter plasmid at 10 uM by reporter gene assay
Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Assay for Thyroid Hormone Receptor Agonist Screening from US Patent US10800767: "Thyroid hormone receptor beta agonist compounds"
Assay data:34 Active, 31 Activity ≤ 1 µM, 36 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
transactivation assay from US Patent US10544075: "Derivatives of sobetirome"
Assay data:4 Active, 1 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
Recruitment Assay from US Patent USRE46024: "Thyroid hormone analogs"
Assay data:22 Active, 12 Activity ≤ 1 µM, 22 Tested
TR Receptor Ligand Binding Assay from Article 10.1016/s1074-5521(98)90168-5: "A high-affinity subtype-selective agonist ligand for the thyroid hormone receptor."
Assay data:3 Active, 2 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
Transactivation Assay in HeLa cells from Article 10.1021/cb600311v: "Design and characterization of a thyroid hormone receptor alpha (TRalpha)-specific agonist."
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Transactivation Assay in U2OS cells from Article 10.1021/cb600311v: "Design and characterization of a thyroid hormone receptor alpha (TRalpha)-specific agonist."
Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested
Competition Binding Assay from Article 10.1021/cb600311v: "Design and characterization of a thyroid hormone receptor alpha (TRalpha)-specific agonist."
Assay data:3 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
TRbeta-Binding Assay from Article 10.1210/endo.137.7.8770901: "Structure-function relationship of the inhibition of the 3,5,3'-triiodothyronine binding to the alpha1- and beta1-thyroid hormone receptor by amiodarone analogs."
Assay data:8 Tested
SummaryPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
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