Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
Assay data:7218 Tested
Summary
SARS-CoV-2 3CL-Pro protease inhibition percentage at 20 M by FRET kind of response from peptide substrate
SummaryRelated BioAssays by Target
Mouse HCN2 (Cyclic nucleotide-regulated channels)
Assay data:7 Active, 7 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Rat CNGA2 (Cyclic nucleotide-regulated channels)
Human CNGA3 (Cyclic nucleotide-regulated channels)
Assay data:3 Active, 3 Tested
Rat CNGA3 (Cyclic nucleotide-regulated channels)
Assay data:2 Active, 2 Tested
Human CNGA1 (Cyclic nucleotide-regulated channels)
Drug transport in human OAT2 expressed in HEK Flp-In cells at 0.05 uM for 10 mins relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
TP_TRANSPORTER: inhibition of E217betaG uptake (E217betaG: 1 uM, cGMP: 300 uM) in membrane vesicles from MRP4-expressing Sf9 cells
TP_TRANSPORTER: inhibition of MTX uptake (MTX: 20 uM, cGMP: 300 uM) in membrane vesicles from MRP4-expressing Sf9 cells
TP_TRANSPORTER: uptake in Xenopus laevis oocytes
Assay data:9 Tested
TP_TRANSPORTER: inhibition of Estradiol-17beta-D-glucuronide uptake by cGMP at a concentration of 10 uM in membrane vesicle from MRP8-expressing LLC-PK1 cells
TP_TRANSPORTER: inhibition of E217betaG uptake (E217betaG: 30 uM, Zaprinast: 100uM) in MRP4-expressing HEK293 cells
Assay data:2 Tested
TP_TRANSPORTER: inhibition of alaninyl-d4TMP uptake (alaninyl-d4TMP: 1 uM, Zaprinast: 100uM) in MRP5-expressing HEK293 cells
TP_TRANSPORTER: uptake in membrane vesicles from MRP5-expressing V79 cells
Assay data:1 Active, 2 Tested
TP_TRANSPORTER: uptake in membrane vesicles from MRP4-expressing Sf9 cells
Assay data:1 Active, 3 Tested
Substrates of transporters of clinical importance in the absorption and disposition of drugs, MRP4
Assay data:8 Tested
Activation of retinal rod olfactory CNG A1B1 channel expressed in Xenopus oocytes assessed as effect on half maximal current
Assay data:2 Active, 1 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Activation of olfactory CNG A2A41b channel expressed in HEK293 cells assessed as effect on half maximal current
Assay data:11 Active, 8 Activity ≤ 1 µM, 17 Tested
Inhibition of canine heart Phosphodiesterase 3
Assay data:4 Active, 3 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on