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Inhibition of human PAK4 expressed in TR-293-KDG cells assessed as inhibition of GEFH1 phosphorylation at S180 using GEFH1 as substrate incubated for 3 hrs by ELISA
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to human PAK4 (300 to 591 residues) assessed as dissociation constant by isothermal calorimetric analysis
Inhibition of human PAK4 assessed as enzymatic activity incubated for 20 mins by filter binding method
Assay data:11 Active, 10 Activity ≤ 1 µM, 11 Tested
Primary qHTS Assay for Inhibitors of Recombinant Selenoprotein Glutathione Peroxidase 4 (GPX4)
Assay data:258 Active, 16 Activity ≤ 1 µM, 11046 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Primary qHTS Assay for Inhibitors of Recombinant Selenoprotein Glutathione Peroxidase 1 (GPX1)
Assay data:186 Active, 9 Activity ≤ 1 µM, 11353 Tested
Thermal Shift Assay. Domain: start/stop: G861-E979
Assay data:1 Tested
SummaryRelated BioAssays by Target
Thermal Shift Assay. Domain: start/stop: E122-S403
Thermal Shift Assay. Domain: start/stop: M1-S360
Thermal Shift Assay. Domain: start/stop: M26-R383
Thermal Shift Assay. Domain: start/stop: P449-E759
Thermal Shift Assay. Domain: start/stop: M1-K294
Thermal Shift Assay. Domain: start/stop: M1-L298
Thermal Shift Assay. Domain: start/stop: M626-G746
Thermal Shift Assay. Domain: start/stop: N44-E168
Thermal Shift Assay. Domain: start/stop: S229-K512
Enzymatic Assay from US Patent US8530652: "Pyrrolopyrazoles, potent kinase inhibitors"
Assay data:78 Active, 77 Activity ≤ 1 µM, 82 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
NCI human tumor cell line growth inhibition assay. Data for the KM12 Non-Small Cell Lung cell line, single concentration
Assay data:3444 Active, 76734 Tested
SummaryCompounds, ActiveRelated BioAssays by Depositor
NCI human tumor cell line growth inhibition assay. Data for the HCC-2998 Non-Small Cell Lung cell line, single concentration
Assay data:3073 Active, 74254 Tested
NCI human tumor cell line growth inhibition assay. Data for the HCT-116 Non-Small Cell Lung cell line, single concentration
Assay data:4943 Active, 74736 Tested
NCI human tumor cell line growth inhibition assay. Data for the MCF7 Non-Small Cell Lung cell line, single concentration
Assay data:4318 Active, 77515 Tested
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