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Incucyte cell viability with U2OS
Assay data:279 Tested
Summary
Incucyte cell viability with human fibroblast
Incucyte cell viability with HEK293T
Multiplex assay against human fibroblast
Assay data:136 Tested
Multiplex assay against U2OS
Multiplex assay against HEK293T
Primary qHTS to identify inhibitors of SARS-CoV-2 cell entry
Assay data:368 Active, 78 Activity ≤ 1 µM, 5114 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Depositor
Cytotoxicity counterscreen for inhibitors of SARS-CoV-2 cell entry
Assay data:158 Active, 29 Activity ≤ 1 µM, 5114 Tested
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
Assay data:7220 Tested
SARS-CoV-2 3CL-Pro protease inhibition percentage at 20 M by FRET kind of response from peptide substrate
SummaryRelated BioAssays by Target
Primary qHTS for Vero E6 cytotoxicity: counterscreen for inhibitors of SARS-S pseudo-typed particle cell entry
Assay data:20 Active, 14 Activity ≤ 1 µM, 2678 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Depositor
Primary qHTS for inhibitors of MERS-S pseudo-typed particle cell entry
Assay data:88 Active, 17 Activity ≤ 1 µM, 2678 Tested
Primary qHTS for Huh7 cytotoxicity: counterscreen for inhibitors of MERS-S pseudotyped particle cell entry
Assay data:25 Active, 8 Activity ≤ 1 µM, 2678 Tested
Primary qHTS for inhibitors of SARS-S pseudo-typed particle cell entry
Assay data:73 Active, 72 Activity ≤ 1 µM, 2678 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Binding affinity to POPC liposome membrane at compound to POPC molar ratio of 1:10 after 3 milliseconds in presence of Mn2+ by 2D NOESY NMR analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed Citation
Binding affinity to POPC liposome membrane in liquid disorder phase assessed as broadening of POPC signals at compound to POPC molar ratio of 1:5 by 1D 1H Mass spectra analysis
Assay data:1 Tested
SummaryPubMed Citation
Lipophilicity of the compound assessed as capacity factor (CHI IAM7.4) at pH 7.4 by chromatographic analysis
Assay data:5 Tested
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