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High-throughput screening primary assay to identify small molecule activators of human guanylyl cyclase B (GC-B) receptor activity
Assay data:399 Active, 370620 Tested
SummaryCompounds, Active
Primary qHTS for Inhibitors of ATXN expression
Assay data:2593 Active, 3 Activity ≤ 1 nM, 2671 Activity ≤ 1 µM, 361713 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
High-throughput screening primary assay to identify small molecule activators of human GC-A enzyme activity
Assay data:519 Active, 370620 Tested
Primary qHTS assay for inhibitors of human arachidonate 12S-lipoxygenase (ALOX12): Round 2
Assay data:6069 Active, 5332 Activity ≤ 1 µM, 575118 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of TAP1/2 in human HeLa cells stably expressing H-2 Kb infected with vaccinia virus containing Ub-SIINFEKL epitope assessed as suppression of Ub-SIINFEKL binding to MHC1 H-2 Kb at cell surface by measuring reduction in 25D1 staining at 50 uM measured after 16 to 24 hrs by flow cytometric method
Assay data:1 Active, 4 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of ERAP1 in human HeLa cells stably expressing H-2 Kb infected with vaccinia virus containing ss-LEQLE-SIINFEKL epitope assessed as suppression of ss-LEQLE-SIINFEKL binding to MHC1 H-2 Kb at cell surface by measuring reduction in 25D1 staining at 50 uM measured after 16 to 24 hrs by flow cytometric method
Assay data:3 Active, 4 Tested
Competitive inhibition of recombinant human C-terminal His6-tagged ERAP1 expressed in baculovirus infected BTA-TN-5B1-4 insect cells using varying levels of L-pNA as substrate incubated for 1 hr and measured for 5 to 10 mins by fluorescence-based Michaelis-Menten equation analysis
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of recombinant human C-terminal His6-tagged ERAP1 expressed in baculovirus infected BTA-TN-5B1-4 insect cells using WRCYEKMALK as substrate measured after 10 mins by LC-MS analysis
Assay data:8 Active, 20 Tested
Selectivity ratio of IC50 for recombinant mouse C-terminal His6-tagged IRAP expressed in baculovirus infected BTA-TN-5B1-4 insect cells to IC50 for recombinant human C-terminal His6-tagged ERAP1 expressed in baculovirus infected BTA-TN-5B1-4 insect cells
SummaryPubMed Citation
Selectivity ratio of IC50 for recombinant human C-terminal His6-tagged ERAP2 expressed in baculovirus infected BTA-TN-5B1-4 insect cells to IC50 for recombinant human C-terminal His6-tagged ERAP1 expressed in baculovirus infected BTA-TN-5B1-4 insect cells
Inhibition of recombinant human C-terminal His6-tagged ERAP2 expressed in baculovirus infected BTA-TN-5B1-4 insect cells using R-AMC as substrate measured after 1 hr by fluorescence assay
Assay data:19 Tested
Inhibition of recombinant mouse C-terminal His6-tagged IRAP expressed in baculovirus infected BTA-TN-5B1-4 insect cells using L-AMC as substrate measured after 1 hr by fluorescence assay
Assay data:20 Tested
Inhibition of recombinant human C-terminal His6-tagged ERAP1 expressed in baculovirus infected BTA-TN-5B1-4 insect cells at 10.7 uM using L-AMC as substrate measured after 1 hr by fluorescence assay relative to control
Inhibition of recombinant human C-terminal His6-tagged ERAP1 expressed in baculovirus infected BTA-TN-5B1-4 insect cells using L-AMC as substrate measured after 1 hr by fluorescence assay
Assay data:3 Active, 11 Tested
Cell-based high throughput primary assay to identify activators of GPR151
Assay data:6756 Active, 646675 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Target
qHTS Assay for Foot and Mouth Disease Virus Antivirals: Primary Screen against the MLPCN compound library
Assay data:1964 Active, 408697 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
qHTS assay for MDR1-selective chemotherapeutics: Primary screen using the drug-selected MDR subline cells KB-V1
Assay data:13449 Active, 399619 Tested
SummaryCompounds, ActiveRelated BioAssays by Depositor
qHTS assay for MDR1-selective chemotherapeutics: Primary screen using the parental adenocarcinoma cell KB-3-1
Assay data:5540 Active, 399561 Tested
qHTS for compounds that reverse cellular toxicity of Amyloid beta (A-beta) peptide in yeast: Primary Screen
Assay data:257 Active, 407462 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Inhibitor identification of TROY dependent signaling using uHTS single point assay
Assay data:3555 Active, 360980 Tested
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