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Inhibition of TAP1/2 in human HeLa cells stably expressing H-2 Kb infected with vaccinia virus containing Ub-SIINFEKL epitope assessed as suppression of Ub-SIINFEKL binding to MHC1 H-2 Kb at cell surface by measuring reduction in 25D1 staining measured after 16 to 24 hrs by flow cytometric method
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Activation of recombinant human C-terminal His6-tagged ERAP2 expressed in baculovirus infected BTA-TN-5B1-4 insect cells using R-AMC as substrate measured after 1 hr by fluorescence assay relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Activation of recombinant human C-terminal His6-tagged ERAP2 expressed in baculovirus infected BTA-TN-5B1-4 insect cells using R-AMC as substrate measured after 1 hr by fluorescence assay
Inhibition of recombinant human C-terminal His6-tagged ERAP1 expressed in baculovirus infected BTA-TN-5B1-4 insect cells using WRCYEKMALK as substrate measured after 10 mins by LC-MS analysis
Assay data:8 Active, 20 Tested
Inhibition of recombinant mouse C-terminal His6-tagged IRAP expressed in baculovirus infected BTA-TN-5B1-4 insect cells using L-AMC as substrate measured after 1 hr by fluorescence assay
Assay data:20 Tested
Inhibition of recombinant human C-terminal His6-tagged ERAP1 expressed in baculovirus infected BTA-TN-5B1-4 insect cells using L-AMC as substrate measured after 1 hr by fluorescence assay
Assay data:3 Active, 11 Tested
HeLa Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-04_Inhibitor_Dose_DryPowder_Activity_Set3
Assay data:19 Tested
SummaryRelated BioAssays by DepositorRelated BioAssays by Same Project
HEK293 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-01_Inhibitor_Dose_DryPowder_Activity_20
Assay data:3 Active, 1 Activity ≤ 1 µM, 68 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Same Project
MLPCN ERAP1 Measured in Biochemical System Using Plate Reader - 7016-01_Inhibitor_Dose_DryPowder_Activity
Assay data:3 Active, 60 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_DryPowder_Activity_Set20
Assay data:2 Active, 60 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Same Project
A549 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-06_Inhibitor_Dose_DryPowder_Activity_18
Assay data:1 Active, 68 Tested
MLPCN ERAP2 Measured in Biochemical System Using Plate Reader - 7016-02_Inhibitor_Dose_DryPowder_Activity_Set2
Assay data:1 Active, 24 Tested
MLPCN IRAP Measured in Biochemical System Using Plate Reader - 7016-03_Inhibitor_Dose_DryPowder_Activity_Set3
MLPCN ERAP1 Measured in Biochemical System Using Plate Reader - 7016-01_Inhibitor_Dose_DryPowder_Activity_Set2
Assay data:24 Tested
SummaryRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
MLPCN ERAP2 Measured in Biochemical System Using Plate Reader - 7016-02_Inhibitor_Dose_DryPowder_Activity
Assay data:60 Tested
MLPCN IRAP Measured in Biochemical System Using Plate Reader - 7016-03_Inhibitor_Dose_DryPowder_Activity_Set2
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