BioAssays, Active for PubChem Compound (Select 3062316) - PubChem BioAssay - NCBI

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Select item 19199581.

Inhibition of SIK; Abl and Src Kinases by Other Kinase Inhibitor from US Patent US20230348453: "HALOGENATED-HETEROARYL AND OTHER HETEROCYCLIC KINASE INHIBITORS, AND USES THEREOF"

Source:: BindingDB

Protein Targets:: Proto-oncogene tyrosine-protein kinase Src; ...
Total:: 5

Assay data:29 Active, 29 Activity ≤ 1 µM, 29 Tested

AID:: 1919958

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19155812.

Cytotoxicity against human DU-145 cells

Source:: ChEMBL

Assay data:4 Active, 1 Activity ≤ 1 µM, 4 Tested

AID:: 1915581

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 19155803.

Cytotoxicity against human K562 cells

Source:: ChEMBL

Assay data:3 Active, 4 Tested

AID:: 1915580

Summary Compounds, Active PubMed Citation

Select item 19155794.

Inhibition of Bcr-Abl (unknown origin)

Source:: ChEMBL

Protein Targets:: Breakpoint cluster region protein; ...
Total:: 2

Assay data:1 Active, 3 Tested

AID:: 1915579

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 18999335.

Inhibition of from NanoLuc-fused Fyn (unknown origin) transfected in HEK293 cells using tracer K4 incubated for 1 hr by NanoBRET assay

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase Fyn

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1899933

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 18938316.

Binding affinity to Abl (unknown origin) assessed as inhibition constant

Source:: ChEMBL

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1893831

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 18938307.

Binding affinity to Src (unknown origin) assessed as inhibition constant

Source:: ChEMBL

Protein Target:: Proto-oncogene tyrosine-protein kinase Src

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1893830

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 18865318.

Inhibition of ABL1 T315I mutant (unknown origin)

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase ABL1

Assay data:2 Active, 3 Tested

AID:: 1886531

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 18865309.

Inhibition of ABL1 (unknown origin)

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase ABL1

Assay data:3 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested

AID:: 1886530

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 188652410.

Growth inhibition of human K562 cells expressing BCR-ABL T315I mutant measured after 48 hrs by alamarblue assay

Source:: ChEMBL

Assay data:24 Active, 16 Activity ≤ 1 µM, 34 Tested

AID:: 1886524

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 188652311.

Growth inhibition of human K562 cells measured after 48 hrs by alamarblue assay

Source:: ChEMBL

Assay data:28 Active, 2 Activity ≤ 1 nM, 27 Activity ≤ 1 µM, 34 Tested

AID:: 1886523

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 187631812.

Antiviral activity against MERS-CoV infected in 1 hr pretreated african green monkey Vero E6 cells measured after 48 hrs by fluorescence based plate reader method

Source:: ChEMBL

Assay data:2 Active, 2 Tested

AID:: 1876318

Summary Compounds, Active PubMed Citation

Select item 187628413.

Inhibition of LCK (unknown origin)

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase Lck

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1876284

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 187628314.

Binding affinity to Fyn (unknown origin) assessed as dissociation constant

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase Fyn

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1876283

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 187628215.

Inhibition of SRC (unknown origin)

Source:: ChEMBL

Protein Target:: Proto-oncogene tyrosine-protein kinase Src

Assay data:5 Active, 2 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 5 Tested

AID:: 1876282

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 187626616.

Binding affinity to GAK (unknown origin) assessed as dissociation constant

Source:: ChEMBL

Protein Target:: Cyclin-G-associated kinase

Assay data:9 Active, 9 Activity ≤ 1 µM, 10 Tested

AID:: 1876266

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 187626017.

Inhibition of Abl (unknown origin)

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase ABL1

Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested

AID:: 1876260

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 187625918.

Antiviral activity against SARS-CoV infected in african green monkey Vero E6 cells measured after 50 hrs by cell-titre glo assay

Source:: ChEMBL

Assay data:3 Active, 3 Tested

AID:: 1876259

Summary Compounds, Active PubMed Citation

Select item 187606319.

Antiviral activity against MERS-CoV

Source:: ChEMBL

Assay data:2 Active, 3 Tested

AID:: 1876063

Summary Compounds, Active PubMed Citation

Select item 187606220.

Inhibition of c-Abl (unknown origin)

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase ABL1

Assay data:3 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested

AID:: 1876062

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

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Proteins (56)
BioAssays with protein sequences specified as targets

BioActivity

Active Compounds (1,201)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (428)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (942)
BioAssays with the active concentration of tested reagents less than 1 micromolar

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Summary (14)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (1,054)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (40)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose

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BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

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Literature Extraction (735)
BioAssays extracted from the literature
NIH MLP (49)
BioAssays deposited by the NIH Molecular Libraries Program
Other (412)
BioAssays deposited by other experimentalists

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