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Inhibition of aromatase (unknown origin)
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of aromatase in human JEG-3 cells using Androst-4-ene-3,17-dione as substrate incubated for 1 hr and measured by BCA assay
Assay data:24 Active, 15 Activity ≤ 1 nM, 26 Activity ≤ 1 µM, 26 Tested
Inhibition of aromatase in human breast tumor
Assay data:5 Active, 4 Activity ≤ 1 µM, 5 Tested
Inhibition of human recombinant aromatase expressed in baculovirus insect cell using 7-methoxy-trifluoromethyl coumarin (MFC) as substrate preincubated for 10 mins followed by substrate addition and measured for 30 mins by fluorescence based assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by cell counter method
Assay data:3 Active, 1 Activity ≤ 1 µM, 14 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Inhibition of human aromatase assessed as reduction in fluorescence intensity preincubated with NADPH regenerating system for 10 mins followed by substrate addition incubated for 60 mins by fluorescence based microplate reader analysis
Assay data:12 Active, 9 Activity ≤ 1 µM, 14 Tested
Aromatase Inhibition Activity Assay from Article 10.1111/cbdd.12812: "Synthesis, biological evaluation, and molecular docking studies of new pyrazol-3-one derivatives with aromatase inhibition activities."
Assay data:11 Active, 11 Activity ≤ 1 µM, 11 Tested
Biological Assay from Article 10.1016/j.bioorg.2004.06.008: "Synthesis and biological evaluation of 4-imidazolylflavans as nonsteroidal aromatase inhibitors."
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
Aromatase Inhibition Assay from Article 10.1021/jm800168s: "Chiral aromatase and dual aromatase-steroid sulfatase inhibitors from the letrozole template: synthesis, absolute configuration, and in vitro activity."
Assay data:20 Active, 2 Activity ≤ 1 nM, 18 Activity ≤ 1 µM, 20 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Assay data:6 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 9 Tested
Cytochrome P450 Family 3 Subfamily A Member 4 (CYP3A4) small molecule antagonists: luciferase reporter qHTS assay
Assay data:1792 Active, 248 Activity ≤ 1 µM, 9667 Tested
Cytochrome P450 Family 2 Subfamily C Member 19 (CYP2C19) small molecule antagonists: luciferase reporter qHTS assay
Assay data:3508 Active, 4 Activity ≤ 1 nM, 319 Activity ≤ 1 µM, 9667 Tested
Inhibition of human aromatase using ASD as substrate incubated for 16 hrs by UV/vis-spectrophotometry
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: luciferase cell-based qHTS assay
Assay data:2147 Active, 1 Activity ≤ 1 nM, 377 Activity ≤ 1 µM, 5242 Tested
Inhibition of recombinant human aromatase using 7-methoxy-trifluoromethylcoumarin as substrate incubated for 30 mins by fluorescence microplate reader analysis
Assay data:14 Active, 14 Activity ≤ 1 µM, 14 Tested
Growth inhibition of human MDA-MB-231 cells incubated for 72 hrs by cell counting based method
Assay data:2 Active, 6 Tested
SummaryCompounds, ActivePubMed Citation
Growth inhibition of human MCF7 cells incubated for 72 hrs by cell counting based method
Assay data:1 Active, 6 Tested
Inhibition of recombinant human aromatase preincubated for 10 mins followed by substrate and beta-NADP+ addition and measured for 60 mins by fluorescence method
Assay data:3 Active, 1 Activity ≤ 1 µM, 7 Tested
Inhibition of recombinant human aromatase expressed in baculovirus infected insect cells using O-benzyl fluorescein benzyl ester as substrate in presence of NADPH generating system by fluorescence based analysis
Assay data:19 Active, 13 Activity ≤ 1 µM, 21 Tested
Inhibition of aromatase in human MCF-7aro cells using [1beta-3H] androstenedione as substrate incubated for 1 hr by liquid scintillation counting method
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