Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
Cytochrome P450 Family 2 Subfamily D Member 6 (CYP2D6) small molecule antagonists: luciferase reporter qHTS assay
Assay data:2225 Active, 268 Activity ≤ 1 µM, 9667 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Drug screen in LFS_MB_P medulloblastoma cells to determine synergistic drug combinations that target childhood tumors with chromothripsis
Assay data:14 Active, 378 Tested
SummaryCompounds, ActiveRelated BioAssays by Depositor
Agonist activity at human PXR in human primary hepatocytes assessed as increase in CYP3A4 gene expression at 1 mM incubated for 24 hrs by RT-PCR analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Agonist activity at human CAR in human primary hepatocytes assessed as increase in CYP2B6 gene expression at 1 mM incubated for 24 hrs by RT-PCR analysis
Human Pregnane X receptor (1I. Vitamin D receptor-like receptors)
Assay data:17 Active, 17 Tested
CCRIS carcinogenicity studies
Assay data:1139 Active, 1767 Tested
SummaryCompounds, Active
GENE-TOX mutagenicity studies
Assay data:1995 Active, 3214 Tested
CCRIS mutagenicity studies
Assay data:4929 Active, 8266 Tested
Transactivation of human CAR1 transfected in human primary hepatocytes assessed as nuclear translocation at 1 mM by confocal laser scanning microscopy
Reduction in MDA level in brain of Swiss albino mouse model of pentylenetetrazole-induced kindling related chronic epilepsy at 30 mg/kg, ip administered daily for 5 weeks followed by injection of 30 mg/kg, ip PTZ on every alternate day till full kindling development by spectrophotometry
SummaryCompounds, ActivePubMed Citation
Anticonvulsant activity in Swiss albino mouse model of pentylenetetrazole-induced kindling related chronic epilepsy assessed as reduction in incidence and seizure severity score by at 30 mg/kg, ip administered daily for 5 weeks followed by injection of 30 mg/kg, ip PTZ on every alternate day till full kindling development
Anticonvulsant activity in albino Mus musculus (mouse) assessed as protection against maximal electroshock-induced seizures at 30 mg/kg, sc after 0.5 hr relative to control
Anticonvulsant activity in albino Mus musculus (mouse) assessed as protection against maximal electroshock-induced seizures at 30 mg/kg, sc after 4 hr relative to control
Anticonvulsant activity in albino Mus musculus (mouse) assessed as protection against subcutaneous pentylenetetrazol-induced seizures at 30 mg/kg, sc after 0.5 hr relative to control
Anticonvulsant activity in albino Mus musculus (mouse) assessed as protection against subcutaneous pentylenetetrazol-induced seizures at 30 mg/kg, sc after 4 hr relative to control
Anticonvulsant activity in Mus musculus Swiss albino (mouse) assessed as protection against subcutaneous pentylenetetrazol-induced clonic spasms at 30 mg/kg, ip after 0.5 hr post compound treatment
Assay data:2 Active, 2 Tested
Anticonvulsant activity in Mus musculus Swiss albino (mouse) assessed as protection against subcutaneous pentylenetetrazol-induced clonic spasms at 30 mg/kg, ip after 4 hr post compound treatment
Metabolic stability in human liver microsomes assessed as GSH adduct formation at 100 uM after 90 mins by HPLC-MS analysis
Assay data:105 Active, 107 Tested
Inhibition of human CYP3A4 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 7-benzyloxyquinoline as substrate after 30 mins
Assay data:155 Active, 221 Tested
Inhibition of human CYP3A4 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using diethoxyfluorescein as substrate after 30 mins
Assay data:138 Active, 221 Tested
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on