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Sterol-Binding Assay from Article 10.1074/jbc.M114.571216: "Oxysterol-binding protein (OSBP)-related protein 4 (ORP4) is essential for cell proliferation and survival."
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Binding Assay from Article 10.1074/jbc.M110.164293: "Structural and biochemical characterization of Mycobacterium tuberculosis CYP142: evidence for multiple cholesterol 27-hydroxylase activities in a human pathogen."
Assay data:5 Active, 5 Activity ≤ 1 µM, 10 Tested
Orthosteric agonist activity at recombinant human N-terminal His6-tagged RORgammat ligand binding domain (265 to 518 residues) expressed in Escherichia coli BL21 (DE3) assessed as increase in coactivator, N-terminal biotinylated SRC-1 box2 peptide recruitment incubated for 60 mins by TR-FRET assay
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Induction of membrane perturbation in DC22:1PC LUV bilayer assessed as fluorescence quench rate by measuring increase in R(drug)/R(control) ratio at gD:lipid molar ratio of > 1:400 in presence of 10 mol % cholesterol by fluorescence quenching assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed Citation
Induction of membrane perturbation in DC22:1PC LUV bilayer assessed as effect on potential of mean force by measuring increase in deltaG for gramicidin mixture monomer to dimer and pure gramicidin-bilayer by fluorescence quenching assay
Assay data:2 Active, 2 Tested
Induction of membrane perturbation in DC18:1PC LUV bilayer assessed as effect on potential of mean force by measuring increase in deltaG for gramicidin mixture monomer to dimer and pure gramicidin-bilayer by fluorescence quenching assay
Binding affinity to full-length recombinant human CYP46A1 by spectral binding study
Assay data:3 Active, 3 Activity ≤ 1 µM, 10 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Agonist activity at 6xHis tagged human RORgammat LBD (262 to 507 residues) expressed in Escherichia coli BL21 (DE3) assessed as biotinylated SRC1-2 peptide coactivator recruitment by AlphaScreen assay
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Human RAR-related orphan receptor-alpha (1F. Retinoic acid-related orphans)
Assay data:4 Active, 4 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of Vesicular stomatitis virus particle bearing EBOV glycoprotein-mediated viral entry in African green monkey Vero cells incubated for 1 hr prior to viral addition measured after 1 hr by fluorescence microscopy relative to control
Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB
Assay data:3916 Active, 206 Activity ≤ 1 nM, 1830 Activity ≤ 1 µM, 3916 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
TP_TRANSPORTER: increase in Daunorubicn intracellular accumulation (Daunorubicin: ? uM) in NIH-G185 cells
qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway
Assay data:583 Active, 1 Activity ≤ 1 nM, 42 Activity ≤ 1 µM, 2810 Tested
Binding affinity to Mycobacterium tuberculosis CYP142A1 assessed as type 1 binding mode at 0.05 to 0.2 uM by UV-visible spectrophotometry
Assay data:14 Active, 14 Tested
Binding affinity to Mycobacterium tuberculosis CYP125A1 assessed as type 1 binding mode at 0.05 to 0.2 uM by UV-visible spectrophotometry
Assay data:11 Active, 11 Tested
Binding affinity to Mycobacterium tuberculosis CYP124A1 assessed as type 1 binding mode at 0.05 to 0.2 uM by UV-visible spectrophotometry
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways
Assay data:588 Active, 2864 Tested
Antibacterial activity against Ochrobactrum pseudogrignonense 21-6 pin by disc-diffusion assay
Assay data:8 Active, 8 Tested
Antibacterial activity against Bacillus sp. by disc-diffusion assay
Inhibition of serum withdrawal-induced cell differentiation in mouse C2C12 cells assessed as myosin heavy chain expression
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