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Binding Assay from US Patent US11285226: "Aryl ethene derivative and pharmaceutical composition containing same as active ingredient"
Assay data:32 Active, 32 Activity ≤ 1 µM, 32 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Binding Assay from US Patent US10934303: "Aryl ethene derivative and pharmaceutical composition containing same as active ingredient"
Assay data:28 Active, 13 Activity ≤ 1 µM, 28 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Assay data:28 Active, 28 Activity ≤ 1 µM, 28 Tested
Radioligand Displacement Assay from Article 10.1016/j.bmcl.2005.11.030: "Structure-guided synthesis of tamoxifen analogs with improved selectivity for the orphan ERRgamma."
Assay data:11 Active, 1 Activity ≤ 1 nM, 11 Activity ≤ 1 µM, 11 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inverse agonist activity at ERRgamma (unknown origin) by luciferase reporter gene assay
Assay data:10 Active, 10 Activity ≤ 1 µM, 10 Tested
Binding affinity to ERalpha (unknown origin) by TR-FRET assay
Assay data:14 Active, 2 Activity ≤ 1 µM, 23 Tested
Binding affinity to ERRgamma (unknown origin) by TR-FRET assay
Assay data:35 Active, 28 Activity ≤ 1 µM, 41 Tested
Binding affinity to GST-tagged ERalpha LBD (unknown origin) using fluorescein PGC1alpha as coactivator incubated for 1 hr by LanthaScreen TR-FRET co-regulator assay
Assay data:19 Active, 12 Activity ≤ 1 µM, 21 Tested
Binding affinity to GST-tagged ERRgamma LBD (unknown origin) using fluorescein PGC1alpha as coactivator incubated for 1 hr by LanthaScreen TR-FRET co-regulator assay
Assay data:42 Active, 24 Activity ≤ 1 µM, 45 Tested
Inverse agonist activity at GAL4-DNA binding domain-fused mouse ERRgamma ligand binding domain expressed in African green monkey CV1 cells assessed as decrease in receptor transcriptional activity after 45 hrs by luciferase reporter gene assay
Assay data:12 Active, 6 Activity ≤ 1 µM, 13 Tested
Inverse agonist activity at GAL4-DNA binding domain-fused human ERRbeta ligand binding domain expressed in African green monkey CV1 cells assessed as decrease in receptor transcriptional activity after 45 hrs by luciferase reporter gene assay
Assay data:12 Active, 9 Activity ≤ 1 µM, 13 Tested
Human Estrogen receptor-alpha (3A. Estrogen receptors)
Assay data:22 Active, 22 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Human Estrogen-related receptor-gamma (3B. Estrogen-related receptors)
Assay data:8 Active, 8 Tested
Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB
Assay data:4302 Active, 250 Activity ≤ 1 nM, 2931 Activity ≤ 1 µM, 4302 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of interaction between ERRgamma and NR cofactor RIP140 in FRET assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Displacement of [3H]estradiol from ERalpha
Displacement of [3H]4-OHT from ERRgamma
Assay data:11 Active, 10 Activity ≤ 1 µM, 11 Tested
Experimentally measured binding affinity data derived from PDB
Assay data:3073 Active, 3073 Tested
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