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Primary qHTS Assay for Inhibitors of Recombinant Selenoprotein Glutathione Peroxidase 4 (GPX4)
Assay data:258 Active, 16 Activity ≤ 1 µM, 11046 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Agonist activity at beta2 adrenoceptor (unknown origin)
Assay data:4 Active, 2 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Agonist activity at beta1 adrenoceptor in electrically stimulated Dunkin Hartley guinea pig left atria assessed as induction of isoprenaline-induced contraction incubated for 10 to 15 mins by alphascreen technology
Assay data:1 Active, 2 Tested
SummaryCompounds, ActivePubMed Citation
Inhibition of human CYP1B1 at 5 uM using 7-ethyl-O-resorufin as substrate incubated for 30 mins in presence of NADPH by EROD assay
Assay data:2 Active, 6 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to POPC liposome membrane at compound to POPC molar ratio of 1:10 after 3 milliseconds in presence of Mn2+ by 2D NOESY NMR analysis
Assay data:1 Active, 1 Tested
Binding affinity to POPC liposome membrane at compound to POPC molar ratio of 1:10 after 3 milliseconds by 2D NOESY NMR analysis
Binding affinity to POPC liposome membrane in liquid disorder phase assessed as change in cross-relaxation rate of lypophilic group E protons with C2/C3 segment at compound to POPC molar ratio of 1:10 to 1:5 by 1D 1H Mass spectra analysis
Binding affinity to POPC liposome membrane in liquid disorder phase assessed as change in cross-relaxation rate of hydrophilic group B protons with G-3 segment at compound to POPC molar ratio of 1:10 to 1:5 by 1D 1H Mass spectra analysis
Assay data:3 Active, 3 Tested
Binding affinity to POPC liposome membrane in liquid disorder phase assessed as change in cross-relaxation rate of hydrophilic group B protons with G-1 segment at compound to POPC molar ratio of 1:10 to 1:5 by 1D 1H Mass spectra analysis
Binding affinity to POPC liposome membrane assessed as cross-relaxation rate of E proton with C-3/C-2 region of lipid at compound to POPC molar ratio of 1:10 by NOESY 1H NMR analysis
Assay data:2 Active, 3 Tested
Binding affinity to POPC liposome membrane assessed as 31P chemical shift anisotropy at compound to POPC molar ratio of 1:10 in presence of Mn2+ by NMR analysis
Human beta1-adrenoceptor (Adrenoceptors)
Assay data:43 Active, 43 Tested
Human beta2-adrenoceptor (Adrenoceptors)
Assay data:47 Active, 47 Tested
Thermodynamic solubility of the compound at pH 6.8
Agonist activity at adrenergic beta1 receptor in guinea-pig left atria assessed as inhibition of electrically-stimulated contraction
Assay data:2 Active, 2 Tested
Agonist activity at adrenergic beta2 receptor in human A431 cells assessed as elevation of cAMP level
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Agonist activity at adrenergic beta2 receptor in electrically-stimulated Dunkin-Hartley guinea pig tracheal strip assessed as inhibition of contraction
Assay data:15 Active, 3 Activity ≤ 1 nM, 15 Activity ≤ 1 µM, 15 Tested
Displacement of [125I]7-HO-PIPAT from human D3R expressed in HEK cells
Assay data:22 Active, 17 Activity ≤ 1 µM, 22 Tested
Displacement of [125I]iodo-(+/-)-cyanopindolol from human adrenergic beta1 receptor expressed in CHO cells after 3 hrs by radio-ligand binding assay
Assay data:24 Active, 1 Activity ≤ 1 nM, 24 Activity ≤ 1 µM, 24 Tested
Displacement of [125I]iodo-(+/-)-cyanopindolol from human adrenergic beta2 receptor expressed in CHO cells after 3 hrs by radio-ligand binding assay
Assay data:24 Active, 4 Activity ≤ 1 nM, 24 Activity ≤ 1 µM, 24 Tested
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