BioAssays, Active for PubChem Compound (Select 6918837) - PubChem BioAssay - NCBI

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Select item 18824671.

Inhibition of HDAC8 (unknown origin)

Source:: ChEMBL

Protein Target:: Histone deacetylase 8

Assay data:5 Active, 3 Activity ≤ 1 µM, 5 Tested

AID:: 1882467

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 18824662.

Inhibition of HDAC3 (unknown origin)

Source:: ChEMBL

Protein Target:: Histone deacetylase 3

Assay data:4 Active, 3 Activity ≤ 1 µM, 5 Tested

AID:: 1882466

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 18824623.

Inhibition of HDAC6 (unknown origin)

Source:: ChEMBL

Protein Target:: Histone deacetylase 6

Assay data:7 Active, 7 Activity ≤ 1 µM, 7 Tested

AID:: 1882462

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 18824564.

Inhibition of HDAC1 (unknown origin)

Source:: ChEMBL

Protein Target:: Histone deacetylase 1

Assay data:6 Active, 3 Activity ≤ 1 µM, 8 Tested

AID:: 1882456

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 18822605.

Inhibition of HDAC6 (unknown origin)

Source:: ChEMBL

Protein Target:: Histone deacetylase 6

Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested

AID:: 1882260

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 18460186.

Anticancer activity against human MED-MEB-8A cells assessed as reduction in cell viability incubated for 72 hrs by CCK assay

Source:: ChEMBL

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1846018

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 18460177.

Anticancer activity against human UW426 cells assessed as reduction in cell viability incubated for 72 hrs by CCK assay

Source:: ChEMBL

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1846017

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 18460168.

Anticancer activity against human UW228 cells assessed as reduction in cell viability incubated for 72 hrs by CCK assay

Source:: ChEMBL

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1846016

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 18459149.

Inhibition of HIV-1 latency in human CD4+ve Th cells infected NL4.3-Luc virus assessed as p24 expression level incubated for 48 hrs by v450 dye based flow cytometry

Source:: ChEMBL

Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested

AID:: 1845914

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 182120210.

Inhibition of human recombinant HDAC11 using Boc-Lys(triflouroacetyI)-AMC substrate incubated for 2 hrs by fluorescence based assay

Source:: ChEMBL

Protein Target:: Histone deacetylase 11

Assay data:1 Active, 1 Activity ≤ 1 µM, 3 Tested

AID:: 1821202

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 182120111.

Inhibition of human recombinant HDAC10 using Boc-Lys(triflouroacetyI)-AMC substrate incubated for 2 hrs by fluorescence based assay

Source:: ChEMBL

Protein Target:: Polyamine deacetylase HDAC10

Assay data:1 Active, 1 Activity ≤ 1 µM, 3 Tested

AID:: 1821201

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 182120012.

Inhibition of human recombinant HDAC9 using Boc-Lys(triflouroacetyI)-AMC substrate incubated for 2 hrs by fluorescence based assay

Source:: ChEMBL

Protein Target:: Histone deacetylase 9

Assay data:1 Active, 1 Activity ≤ 1 µM, 3 Tested

AID:: 1821200

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 182119913.

Inhibition of human recombinant HDAC8 using Boc-Lys(triflouroacetyI)-AMC substrate incubated for 2 hrs by fluorescence based assay

Source:: ChEMBL

Protein Target:: Histone deacetylase 8

Assay data:1 Active, 1 Activity ≤ 1 µM, 3 Tested

AID:: 1821199

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 182119814.

Inhibition of human recombinant HDAC7 using Boc-Lys(triflouroacetyI)-AMC substrate incubated for 2 hrs by fluorescence based assay

Source:: ChEMBL

Protein Target:: Histone deacetylase 7

Assay data:1 Active, 1 Activity ≤ 1 µM, 3 Tested

AID:: 1821198

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 182119715.

Inhibition of human recombinant HDAC5 using Boc-Lys(triflouroacetyI)-AMC substrate incubated for 2 hrs by fluorescence based assay

Source:: ChEMBL

Protein Target:: Histone deacetylase 5

Assay data:1 Active, 1 Activity ≤ 1 µM, 3 Tested

AID:: 1821197

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 182119616.

Inhibition of human recombinant HDAC4 using Boc-Lys(triflouroacetyI)-AMC substrate incubated for 2 hrs by fluorescence based assay

Source:: ChEMBL

Protein Target:: Histone deacetylase 4

Assay data:1 Active, 1 Activity ≤ 1 µM, 3 Tested

AID:: 1821196

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 182118717.

Cmax in CD-1 mouse at 50 mg/kg, po measured upto 24 hrs

Source:: ChEMBL

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1821187

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 181668818.

Inhibition of HDAC5 (unknown origin) using Ac-peptide as substrate preincubated for 15 mins followed by substrate addition by fluorescence assay

Source:: ChEMBL

Protein Target:: Histone deacetylase 5

Assay data:2 Active, 1 Activity ≤ 1 µM, 21 Tested

AID:: 1816688

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 180466519.

Enzyme Assay from US Patent US10722597: "Cyclodextrin-panobinostat adduct"

Source:: BindingDB

Protein Targets:: Histone deacetylase 1; ...
Total:: 11

Assay data:4 Active, 1 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested

AID:: 1804665

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 180201120.

HDAC6 fluorescence anisotropy assay from Article 10.1038/nchembio.2134: "Histone deacetylase 6 structure and molecular basis of catalysis and inhibition"

Source:: BindingDB

Protein Targets:: Histone deacetylase 6; ...
Total:: 1

Assay data:9 Active, 3 Activity ≤ 1 nM, 9 Activity ≤ 1 µM, 9 Tested

AID:: 1802011

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

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Proteins (20)
BioAssays with protein sequences specified as targets

BioActivity

Active Compounds (386)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (55)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (247)
BioAssays with the active concentration of tested reagents less than 1 micromolar

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Confirmatory (320)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (3)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose

Assay Project (2)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

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Literature Extraction (293)
BioAssays extracted from the literature
NIH MLP (10)
BioAssays deposited by the NIH Molecular Libraries Program
Other (83)
BioAssays deposited by other experimentalists

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