BioAssays, activity concentration at/below 1 uM for PubChem Compound ( - PubChem BioAssay - NCBI

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Items: 20

Select item 19143211.

Selectivity interaction (MMPs panel (enzymatic assay)) EUB0000729a MMP8

Source:: ChEMBL

Protein Target:: Neutrophil collagenase

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1914321

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19143192.

Selectivity interaction (MMPs panel (enzymatic assay)) EUB0000729a MMP3

Source:: ChEMBL

Protein Target:: Stromelysin-1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1914319

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19143183.

Selectivity interaction (MMPs panel (enzymatic assay)) EUB0000729a MMP2

Source:: ChEMBL

Protein Target:: 72 kDa type IV collagenase

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1914318

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19143164.

Selectivity interaction (MMPs panel (enzymatic assay)) EUB0000729a MMP10

Source:: ChEMBL

Protein Target:: Stromelysin-2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1914316

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19143135.

Selectivity interaction (GPCR panel (PDSP screen)) EUB0000729a HRH1

Source:: ChEMBL

Protein Target:: Histamine H1 receptor

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1914313

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19132266.

Affinity Biochemical interaction (Enzyme inhibition assay) EUB0000729a MMP13

Source:: ChEMBL

Protein Target:: Collagenase 3

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913226

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19127777.

Affinity Phenotypic Cellular interaction (Bovine nasal cartilage assay (inhibitory activity against collagen degradation)) EUB0000729a MMP13

Source:: ChEMBL

Protein Target:: Collagenase 3

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1912777

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 17944268.

GPCRScan assay: inhibition of H1

Source:: ChEMBL

Protein Target:: Histamine H1 receptor

Assay data:2 Active, 2 Activity ≤ 1 µM, 179 Tested

AID:: 1794426

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 17915169.

MMP inhibition assay (MMP10)

Source:: ChEMBL

Protein Target:: Stromelysin-2

Assay data:1 Activity ≤ 1 µM, 1 Tested

AID:: 1791516

Summary Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 179151410.

MMP inhibition assay (MMP8)

Source:: ChEMBL

Protein Target:: Neutrophil collagenase

Assay data:1 Activity ≤ 1 µM, 1 Tested

AID:: 1791514

Summary Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 179151211.

MMP inhibition assay (MMP3)

Source:: ChEMBL

Protein Target:: Stromelysin-1

Assay data:1 Activity ≤ 1 µM, 1 Tested

AID:: 1791512

Summary Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 179151112.

MMP inhibition assay (MMP2)

Source:: ChEMBL

Protein Target:: 72 kDa type IV collagenase

Assay data:1 Activity ≤ 1 µM, 1 Tested

AID:: 1791511

Summary Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 179150813.

MMP inhibition assay (MMP13)

Source:: ChEMBL

Protein Target:: Collagenase 3

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1791508

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 147619214.

Inhibition of C-terminal tagged human recombinant MMP13 catalytic domain expressed in Escherichia coli using (5-FAM/QX) FRET peptide as substrate by fluorescence assay

Source:: ChEMBL

Protein Target:: Collagenase 3

Assay data:18 Active, 1 Activity ≤ 1 nM, 18 Activity ≤ 1 µM, 18 Tested

AID:: 1476192

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 147619115.

Inhibition of MMP10 (unknown origin) assessed using (5-FAM/QX) FRET peptide as substrate by fluorescence assay

Source:: ChEMBL

Protein Target:: Stromelysin-2

Assay data:18 Active, 13 Activity ≤ 1 µM, 18 Tested

AID:: 1476191

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 116279016.

Inhibition of human recombinant MMP10 using fluorescence peptide Cy3-PLGLK(Cy5Q)AR-NH2 substrate by fluorescence assay

Source:: ChEMBL

Protein Target:: Stromelysin-2

Assay data:3 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 3 Tested

AID:: 1162790

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 116278817.

Inhibition of human recombinant MMP8 using fluorescence peptide Cy3-PLGLK(Cy5Q)AR-NH2 substrate by fluorescence assay

Source:: ChEMBL

Protein Target:: Neutrophil collagenase

Assay data:3 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 3 Tested

AID:: 1162788

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 116278618.

Inhibition of human recombinant MMP3 using fluorescence peptide Cy3-PLGLK(Cy5Q)AR-NH2 substrate by fluorescence assay

Source:: ChEMBL

Protein Target:: Stromelysin-1

Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 3 Tested

AID:: 1162786

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 116278519.

Inhibition of human recombinant MMP2 using fluorescence peptide Cy3-PLGLK(Cy5Q)AR-NH2 substrate by fluorescence assay

Source:: ChEMBL

Protein Target:: 72 kDa type IV collagenase

Assay data:3 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested

AID:: 1162785

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 116278020.

Inhibition of human recombinant MMP13 catalytic domain using fluorescence peptide Cy3-PLGLK(Cy5Q)AR-NH2 substrate by fluorescence assay

Source:: ChEMBL

Protein Target:: Collagenase 3

Assay data:36 Active, 17 Activity ≤ 1 nM, 34 Activity ≤ 1 µM, 39 Tested

AID:: 1162780

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

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BioActivity

Active Compounds (16)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (8)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (20)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Confirmatory (20)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations

Depositor Category

Literature Extraction (7)
BioAssays extracted from the literature
Other (13)
BioAssays deposited by other experimentalists

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