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Nuclear factor erythroid 2-related factor 2/antioxidant responsive element (Nrf2/ARE) small molecule agonists: luciferase reporter gene qHTS assay in human keratinocytes
Assay data:1099 Active, 1 Activity ≤ 1 nM, 143 Activity ≤ 1 µM, 9667 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Same Project
Inhibition of SIK; Abl and Src Kinases by Other Kinase Inhibitor from US Patent US20230348453: "HALOGENATED-HETEROARYL AND OTHER HETEROCYCLIC KINASE INHIBITORS, AND USES THEREOF"
Assay data:29 Active, 29 Activity ≤ 1 µM, 29 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of from NanoLuc-fused Fyn (unknown origin) transfected in HEK293 cells using tracer K4 incubated for 1 hr by NanoBRET assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to Abl (unknown origin) assessed as inhibition constant
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Binding affinity to Src (unknown origin) assessed as inhibition constant
Inhibition of ABL1 (unknown origin)
Assay data:3 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
Growth inhibition of human K562 cells measured after 48 hrs by alamarblue assay
Assay data:28 Active, 2 Activity ≤ 1 nM, 27 Activity ≤ 1 µM, 34 Tested
Inhibition of LCK (unknown origin)
Binding affinity to Fyn (unknown origin) assessed as dissociation constant
Inhibition of SRC (unknown origin)
Assay data:5 Active, 2 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 5 Tested
Binding affinity to GAK (unknown origin) assessed as dissociation constant
Assay data:9 Active, 9 Activity ≤ 1 µM, 10 Tested
Inhibition of Abl (unknown origin)
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Inhibition of c-Abl (unknown origin)
Antiviral activity against pseudo typed HCV infected in human Huh-7.5.1 cells assessed as inhibition of viral infection
Antiviral activity against pseudo typed HCV infected in human Huh-7.5.1 cells assessed as prevention of pseudo particle entry
Inhibition of LIMK1/LIMK2 in human SH-SY5Y cells assessed as effect on phospho cofilin serine 3 phosphorylation incubated for 2 hr by AlphaLISA SureFire assay
Assay data:11 Active, 11 Activity ≤ 1 µM, 17 Tested
Inhibition of recombinant LIMK2(unknown origin) expressed in HEK293 cells using NanoGlo substrate incubated for 2 hrs followed by substrate addition by NanoBRET assay
Assay data:12 Active, 12 Activity ≤ 1 µM, 17 Tested
Inhibition of recombinant LIMK2 (347 to 659 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 180 mins by RapidFire Mass Spectrometry kinase assay
Assay data:17 Active, 14 Activity ≤ 1 µM, 21 Tested
Inhibition of recombinant LIMK1 (330 to 637 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 105 mins by RapidFire Mass Spectrometry kinase assay
Assay data:19 Active, 18 Activity ≤ 1 µM, 21 Tested
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
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