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HSP70 Biacore Direct Binding Assay from Article 10.1021/jm801627a: "Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design."
Assay data:7 Active, 6 Activity ≤ 1 µM, 8 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
HSP70 Fluorescence Polarization Assay from Article 10.1021/jm801627a: "Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design."
Assay data:14 Active, 6 Activity ≤ 1 µM, 17 Tested
Binding affinity to human truncated HSC70 NBD (1 to 381 residues) by SPR analysis
Assay data:11 Active, 5 Activity ≤ 1 µM, 20 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Agonist activity at GFP-tagged human P2Y1R transfected in human 1321N1 cells assessed as increase in intracellular Ca2+ level by fura 2/AM probe-based fluorescence assay
Assay data:10 Active, 9 Activity ≤ 1 µM, 10 Tested
Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB
Assay data:3916 Active, 206 Activity ≤ 1 nM, 1830 Activity ≤ 1 µM, 3916 Tested
Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB
Assay data:4302 Active, 250 Activity ≤ 1 nM, 2931 Activity ≤ 1 µM, 4302 Tested
Agonist activity at human GFP-tagged P2Y1R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluorescence assay
Assay data:14 Active, 11 Activity ≤ 1 µM, 16 Tested
Inhibition of HSP70 by fluorescence polarization assay
Assay data:14 Active, 4 Activity ≤ 1 µM, 14 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Binding affinity to HSP70 by surface plasmon resonance analysis
Assay data:3 Active, 3 Activity ≤ 1 µM, 4 Tested
Binding affinity to human Hsc70 by isothermal calorimetry assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Binding affinity to Hsp70
Binding affinity to bovine Hsc70 by filter binding assay
Agonist activity at G-protein coupled P2Y1 receptor expressed in human 1321N1 cells assessed as increase in calcium by Fura2 assay
Assay data:6 Active, 6 Activity ≤ 1 µM, 7 Tested
Inhibition of rat ecto-5'-nucleotidase expressed in Sf9 cells by capillary electrophoresis method
Assay data:22 Active, 2 Activity ≤ 1 nM, 8 Activity ≤ 1 µM, 31 Tested
Binding affinity to HSP70 by Biocore direct binding assay
Assay data:8 Active, 7 Activity ≤ 1 µM, 10 Tested
Displacement of fluorescein labeled N6-(6-amino)hexyl-ATP-5-FAM from HSP70 by fluorescence polarization assay
Assay data:15 Active, 6 Activity ≤ 1 µM, 17 Tested
Agonist activity at turkey P2Y1 receptor expressed in human 1321N1 cells assessed as increase in intracellular calcium concentration by dual-excitation spectrofluorimetric analysis
Assay data:3 Active, 3 Activity ≤ 1 µM, 5 Tested
Antagonist activity against phospholipase C coupled rat P2Y purinoceptor 12 (P2Y12)
Assay data:7 Active, 4 Activity ≤ 1 µM, 12 Tested
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