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Binding affinity to Abl (unknown origin) assessed as inhibition constant
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Binding affinity to Src (unknown origin) assessed as inhibition constant
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of ABL1 (unknown origin)
Assay data:3 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
Growth inhibition of human K562 cells measured after 48 hrs by alamarblue assay
Assay data:28 Active, 2 Activity ≤ 1 nM, 27 Activity ≤ 1 µM, 34 Tested
Inhibition of LCK (unknown origin)
Binding affinity to Fyn (unknown origin) assessed as dissociation constant
Inhibition of SRC (unknown origin)
Assay data:5 Active, 2 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 5 Tested
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of BCR-ABL phosphorylation in human K562 cells
Inhibition of CSF1R (unknown origin) by enzymatic assay
Cytotoxicity against human KU812 cells assessed as inhibition of cell growth measured after 72 hrs by MTT assay
Assay data:10 Active, 6 Activity ≤ 1 nM, 10 Activity ≤ 1 µM, 10 Tested
Cytotoxicity against human K562 cells assessed as cell growth inhibition measured after 72 hrs by MTT assay
Cytotoxicity against mouse BAF3 cells expressing native BCR-ABL assessed as inhibition of cell growth measured after 72 hrs by MTT assay
Assay data:9 Active, 2 Activity ≤ 1 nM, 10 Activity ≤ 1 µM, 10 Tested
FRET-Based Z'-Lyte Assay from Article 10.1111/cbdd.12863: "Synthesis and biological evaluation of novel dasatinib analogues as potent DDR1 and DDR2 kinase inhibitors."
Assay data:26 Active, 25 Activity ≤ 1 nM, 26 Activity ≤ 1 µM, 26 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
HotSpot Kinase Activity Assay from Article 10.1021/acschembio.6b00709: "Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs."
Assay data:15 Active, 2 Activity ≤ 1 nM, 15 Activity ≤ 1 µM, 15 Tested
Kinome-Wide Inhibitor Profiling from Article 10.1021/acschembio.5b01018: "Conformation-Selective Analogues of Dasatinib Reveal Insight into Kinase Inhibitor Binding and Selectivity."
Assay data:9 Active, 4 Activity ≤ 1 nM, 9 Activity ≤ 1 µM, 9 Tested
Kinase Assay from Article 10.1111/j.1747-0285.2007.00556.x: "Crystal structure of the T315I mutant of AbI kinase."
Assay data:6 Active, 1 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 6 Tested
Tyrosine Kinase Inhibition Assay from Article 10.1038/nchembio.162: "A new screening assay for allosteric inhibitors of cSrc."
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 4 Tested
Kinetics Assay for IC50 Determination from Article 10.1021/jm9002928: "Hybrid compound design to overcome the gatekeeper T338M mutation in cSrc."
Assay data:7 Active, 1 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 9 Tested
Kinase Assay and Binding Constant Measurement from Article 10.1073/pnas.0504952102: "Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases."
Assay data:7 Active, 3 Activity ≤ 1 nM, 7 Activity ≤ 1 µM, 7 Tested
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