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Agonist activity against human RARalpha in human HEK293T cells co-expressing pFR/pRL-Luc assessed as receptor activation at 10 uM incubated for 14 to 16 hrs by hybrid reporter gene assay relative to bexarotene
Assay data:3 Tested
SummaryPubMed CitationRelated BioAssays by Target
Antagonist activity against human RARalpha assessed as inhibition of 9-cis-RA-induced luciferase expression at 1 uM incubated for 24 hrs by luciferase reporter gene assay
Assay data:1 Tested
Antagonist activity against human RARalpha at 1 uM incubated for 24 hrs by luciferase reporter gene assay
Activation of human RAR-alphaLBD expressed in HEK293T cells assessed as induction of receptor activation at 10 uM incubated for 12 to 14 hrs by luciferase reporter gene assay
Agonist activity at human RARalpha transfected in human HuH7 cells assessed as receptor transactivation at 1 uM by luciferase reporter gene assay
Assay data:2 Tested
Agonist activity at human RARalpha expressed in HEK293 cells assessed as increase in RARE-mediated transcription at 100 nM incubated for 24 hrs by RARE luciferase reporter gene assay relative to all-trans-retinoic acid
Inhibition of human RARalpha transfected in human HEK293 cells co-expressing CMV-beta galactosidase assessed as effect on beta-galactosidase activity at 50 uM after 48 hrs by luciferase reporter gene assay
Assay data:13 Tested
Agonist activity RARalpha (unknown origin) assessed as induction of receptor transactivation
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Antagonist activity at RAR (unknown origin) by Alpha Screen assay
Agonist activity at RAR (unknown origin) by Alpha Screen assay
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 2 Tested
Antagonist activity at recombinant human pFA-CMV fused RARalpha LBD transfected in HEK293T cells assessed as reduction in tretinoin-induced RARalpha activation at 1 uM incubated for 12 to 14 hrs by dual glo luciferase reporter gene assay
Agonist activity at recombinant human pFA-CMV fused RARalpha LBD transfected in HEK293T cells assessed as RARalpha activation at 1 uM incubated for 12 to 14 hrs by dual glo luciferase reporter gene assay
Agonist activity at RAR (unknown origin) at 10 uM
Antagonist activity at human RARalpha expressed in HuH7 cells assessed as inhibition of ATRA-induced response at 1 uM incubated for 24 hrs by RARalpha response element driven luciferase reporter gene assay
Agonist activity at human Gal4-DBD fused RARalpha LBD expressed in HEK293T cells at 30 uM after 12 to 14 hrs by luciferase reporter gene assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Agonist activity at Gal4-LBD fused RARalpha (unknown origin) expressed in HEK293T cells at 10 uM after 14 to 16 hrs by dual-Glo luciferase assay
Assay data:2 Active, 2 Tested
Agonist activity at Gal4-LBD fused RARalpha (unknown origin) expressed in HEK293T cells at 20 uM after 14 to 16 hrs by dual-Glo luciferase assay
Agonist activity at RAR alpha (unknown origin)
Antagonist activity at GAL4-tagged human RARalpha1 ligand binding domain (177 to 462 residues) expressed in HEK293T cells at 1 uM after 12 to 14 hrs by dual-glo luciferase reporter gene assay
Transactivation of GAL4-tagged human RARalpha1 ligand binding domain (177 to 462 residues) expressed in HEK293T cells at 1 uM after 12 to 14 hrs by dual-glo luciferase reporter gene assay
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