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Inhibition of rat ADCY10 overexpressed in rat 4-4 cells assessed as IBMX stimulated cAMP accumulation preincubated for 10 mins followed by IBMX stimulation and measured after 5 mins by ELISA
Assay data:11 Active, 11 Activity ≤ 1 µM, 11 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Inhibition of rat soluble adenylyl cyclase overexpressed in rat 4-4 cells assessed as reduction in cAMP accumulation
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Cmax in male Wistar Han rat at 0.54 mg/kg, iv measured after 24 hrs by LC-MS/MS analysis
Cmax in male Wistar Han rat at 0.6 mg/kg, iv measured after 24 hrs by LC-MS/MS analysis
Cmax in male Wistar Han rat at 0.53 mg/kg, iv measured after 24 hrs by LC-MS/MS analysis
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Cmax in male Sprague-Dawley rat at 20 mg/kg, po measured by LC-MS/MS analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed Citation
Cytotoxicity against rat H9c2 cells incubated for 48 hrs and measured by MTT assay
Assay data:1 Active, 6 Tested
Cmax in male Sprague-Dawley rat at 10 mg/kg, po
Cmax in male Sprague-Dawley rat at 2.5 mg/kg, iv
Assay data:1 Tested
SummaryPubMed Citation
Cmax in Sprague-Dawley rat at 5 mg/kg, po measured upto 24 hrs by LC-MS/MS analysis
Cmax in Sprague-Dawley rat at 10 mg/kg,po
Assay data:13 Active, 12 Activity ≤ 1 µM, 13 Tested
Inhibition of serotonin transporter in rat brain tissue assessed as inhibition of [3H]-5-hydroxytryptamine reuptake
Assay data:5 Active, 1 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Drug concentration in rat Synovial fluid at 20 mg/kg,ip measured after 4 hr by HPLC-MS analysis
Assay data:2 Active, 2 Tested
Drug concentration in rat plasma at 20 mg/kg,ip measured after 4 hr by HPLC-MS analysis
Assay data:2 Tested
Drug concentration in rat plasma at 20 mg/kg,ip measured after 2 hr by HPLC-MS analysis
Drug concentration in rat plasma at 20 mg/kg,ip measured after 1 hr by HPLC-MS analysis
Inhibition of N-terminal His-tagged full length rat LMW-PTP expressed in Escherichia coli BL21(DE3)
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Unbound Cmax in plasma of Sprague-Dawley rat at 3 mg/kg, po measured after 24 hrs by LC-MS/MS analysis
Unbound Cmax in plasma of Sprague-Dawley rat at 30 mg/kg, po measured after 24 hrs by LC-MS/MS analysis
Cmax in Sprague-Dawley rat plasma at 3 mg/kg, po measured after 24 hrs by LC-MS/MS analysis
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