Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
Inhibition of monkey DHODH
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Antialzheimer activity against in po dosed rhesus monkey assessed as plasma concentration required to 50 % decrease in amyloid beta 40 in CSF measured after 3 hrs
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Cmax in rhesus monkey at 0.05 mg/kg, sc by LC-MS analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Agonist activity at rhesus monkey GLP1R
Assay data:10 Active, 10 Activity ≤ 1 nM, 10 Activity ≤ 1 µM, 10 Tested
Agonist activity at rhesus monkey GCGR
Assay data:9 Active, 9 Activity ≤ 1 nM, 9 Activity ≤ 1 µM, 9 Tested
Stability in monkey whole blood
Assay data:1 Tested
SummaryPubMed Citation
Metabolic stability in monkey liver microsomes assessed metabolic bioavailability at 0.1 uM in presence of NADPH measured by LC-MS/MS analysis
Assay data:2 Tested
Drug metabolism in monkey liver microsomes assessed as N-acetyl M2 metabolite formation at 3 uM incubated for 3 hrs by UPLC/Q-TOF MS analysis
Drug metabolism in monkey liver microsomes assessed as amino dealkylation of parent compound causing M1 metabolite formation at 3 uM incubated for 3 hrs by UPLC/Q-TOF MS analysis
Microsomal stability in monkey liver microsomes assessed as half life preincubated with NADPH measured upto 60 mins by LC-MS analysis
Stability in monkey liver microsomes assessed as half life incubated in presence of NADPH by LC-MS/MS analysis
Protein binding in monkey plasma assessed as fraction unbound incubated for 6 hrs by LC-MS/MS analysis
Drug uptake in monkey striatum assessed as standard uptake value
Volume of distribution in monkey brain
Drug uptake in monkey brain assessed as maximum standard uptake value
Assay data:5 Tested
Drug uptake in rhesus monkey brain assessed as standard uptake value
Drug uptake in rhesus macaques monkey brain assessed as maximum standard uptake value
Drug uptake in rhesus monkey brain assessed as maximum standard uptake value
Drug uptake in LPS injected monkey brain assessed as increased radioactivity accumulation relative to control
Drug uptake in rhesus monkey brain assessed as standard uptake value at 7 min followed by rapid washout and measured after 85 min
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on