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Hemolytic activity against rabbit erythrocytes incubated for 30 mins in presence of human serum and measured by hemolysis assay
Assay data:21 Active, 16 Activity ≤ 1 µM, 50 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Inhibition of rabbit liver PP2C assessed as dephosphorylation of substrate using P32 labelled peptide as substrate by radiometric analysis
Assay data:4 Tested
SummaryPubMed Citation
Activation of rabbit GLP-1R expressed in CHO cells assessed as increase in cAMP accumulation
Assay data:1 Tested
Displacement of [125I]Sar1,I1e8-AII from AT1 receptor in rabbit aorta membrane
Assay data:3 Active, 2 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of rabbit stomach K+ stimulated H(+)/K(+) ATPase activity incubated for 30 mins in presence of ATP and KCl by malachite green reagent based assay
Assay data:38 Active, 26 Activity ≤ 1 µM, 42 Tested
Ex vivo agonist activity at GPR38 in rabbit duodenum muscle tissue assessed as intestinal contractile activity
Assay data:5 Active, 1 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 5 Tested
Agonist activity at rabbit GPR38 expressed in COS-7 cells
Assay data:18 Active, 9 Activity ≤ 1 nM, 17 Activity ≤ 1 µM, 22 Tested
Anticoagulant activity in platelet poor plasma of anesthetized New Zealand White rabbit model of AV shunt-induced thrombosis assessed as enhancement of activated partial thromboplastin time incubated for 3 mins by coagulometer analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed Citation
Drug concentration in plasma of anesthetized New Zealand White rabbit model of AV shunt-induced thrombosis at 8.5 mg/kg, administered as iv bolus dose and subsequently followed by 10 mg/kg/hr as iv infusion from 20 min prior to 40 min after establishment of AV shunt by LC-MS/MS analysis
Drug concentration in plasma of anesthetized New Zealand White rabbit model of AV shunt-induced thrombosis at 1.7 mg/kg, administered as iv bolus dose and subsequently followed by 0.8 mg/kg/hr as iv infusion from 20 min prior to 40 min after establishment of AV shunt by LC-MS/MS analysis
Inhibition of rabbit coagulation factor XIa (19 to 624 residues) expressed in Expi293F cells assessed as inhibition constant using 5FAM-Lys.Leu-Thr-Arg-Ala-Glu-Thr-Val-Lys(5Tamra)-amide as substrate preincubated for 30 mins followed by substrate addition and measured after 30 mins by fluorescence based assay
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Hemolytic activity in rabbit RBC incubated for 1 hrs in the presence of 12.5 ug/mL Zn2+ by fluorescence based microplate reader assay
Assay data:13 Tested
Hemolytic activity in rabbit RBC incubated for 1 hrs by fluorescence based microplate reader assay
Assay data:21 Tested
Hemolytic activity in rabbit RBC measured after 1 hrs by multimode reader assay
Assay data:40 Tested
Inhibition of recombinant rabbit GSK-3beta using peptide YRRAAVPPSPSLSRHSSPHQ(pS)EDEEE as substrate incubated for 10 mins
Antiplatelet aggregation activity in rabbit plasma incubated for 5 mins
Assay data:2 Active, 2 Tested
Antiplatelet aggregation activity in rabbit platelet assessed as reduction in ADP-induced platelet aggregation
Assay data:1 Active, 5 Tested
Antiplatelet activity in rabbit platelet rich plasma assessed as inhibition of ADP-induced platelet aggregation preincubated for 5 mins followed by ADP addition and measured after 5 mins by turbidimetric method
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Bronchodilatory activity in iv dosed rabbit model assessed as inhibition of acetylcholine-induced bronchoconstriction measured after 1 min by Konzett-Roessler methodology relative to control
Assay data:2 Tested
Bronchodilatory activity in rabbit model assessed as inhibition of acetylcholine-induced bronchoconstriction at 1 ug/kg, iv measured after 45 mins by Konzett-Roessler methodology relative to control
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