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CDK Kinase Assays from US Patent US11053238: "Benzimidazole derivatives, preparation methods and uses thereof"
Assay data:15 Active, 15 Activity ≤ 1 µM, 15 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Biological Assay from US Patent US20230312583: "1H-IMIDAZO [4,5-H] QUINAZOLINE COMPOUND AS NOVEL SELECTIVE FLT3 INHIBITORS"
Assay data:21 Active, 11 Activity ≤ 1 nM, 21 Activity ≤ 1 µM, 21 Tested
Kinase Inhibition Assay from Article 10.1074/jbc.M500805200: "Crystal structure of pyridoxal kinase in complex with roscovitine and derivatives."
Assay data:1 Active, 1 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Kinase Inhibition Assay from Article 10.1016/j.bmcl.2006.03.060: "Suzuki-type Pd(0) coupling reactions in the synthesis of 2-arylpurines as Cdk inhibitors."
Assay data:11 Active, 2 Activity ≤ 1 µM, 11 Tested
Kinase Inhibition Assay from Article 10.1021/jm990506w: "Docking-based development of purine-like inhibitors of cyclin-dependent kinase-2."
Assay data:9 Active, 5 Activity ≤ 1 µM, 10 Tested
Kinase Inhibition Assay from Article 10.1021/jm9911130: "Cyclin-dependent kinase inhibition by new C-2 alkynylated purine derivatives and molecular structure of a CDK2-inhibitor complex."
Assay data:15 Active, 14 Activity ≤ 1 µM, 15 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Kinase Inhibition Assay from Article 10.1016/s0960-894x(98)00097-3: "Synthesis of C2 alkynylated purines, a new family of potent inhibitors of cyclin-dependent kinases."
Assay data:17 Active, 9 Activity ≤ 1 µM, 17 Tested
Kinase Inhibition Assay from Article 10.1016/S0968-0896(02)00069-X: "Pyrazolo[3,4-b]quinoxalines. A new class of cyclin-dependent kinases inhibitors."
Assay data:5 Active, 1 Activity ≤ 1 µM, 17 Tested
Kinase Inhibition Assay from Article 10.1016/S0968-0896(99)00064-4: "Synthesis and in vitro evaluation of novel 2,6,9-trisubstituted purines acting as cyclin-dependent kinase inhibitors."
Assay data:19 Active, 9 Activity ≤ 1 µM, 31 Tested
CDK 1 Inhibition Assay from Article 10.1021/jm0108348: "Structure-based design and synthesis of 2-benzylidene-benzofuran-3-ones as flavopiridol mimics."
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Depositor
Kinase Inhibition Assay from Article 10.1016/j.bmcl.2003.10.062: "1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3 beta."
Assay data:7 Active, 6 Activity ≤ 1 µM, 7 Tested
Kinase Inhibition Assay from Article 10.1021/jm058013g: "Pyrazolo[3,4-c]pyridazines as novel and selective inhibitors of cyclin-dependent kinases."
Assay data:11 Active, 2 Activity ≤ 1 µM, 30 Tested
Kinase Inhibition Assay from Article 10.1021/jm049353p: "Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin."
Assay data:7 Active, 3 Activity ≤ 1 µM, 7 Tested
Kinase Inhibition Assay from Article 10.1016/j.bmcl.2004.10.091: "Novel CDK inhibition profiles of structurally varied 1-aza-9-oxafluorenes."
Assay data:12 Active, 2 Activity ≤ 1 µM, 23 Tested
Kinase Inhibition Assay from Article 10.1021/jm031016d: "Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases."
Assay data:32 Active, 31 Activity ≤ 1 µM, 38 Tested
Kinase Inhibition Assay from Article 10.1021/jm020319p: "Aloisines, a new family of CDK/GSK-3 inhibitors. SAR study, crystal structure in complex with CDK2, enzyme selectivity, and cellular effects."
Assay data:40 Active, 18 Activity ≤ 1 µM, 51 Tested
Kinase Inhibition Assay from Article 10.1021/jm0308904: "Evaluation and comparison of 3D-QSAR CoMSIA models for CDK1, CDK5, and GSK-3 inhibition by paullones."
Assay data:18 Active, 13 Activity ≤ 1 µM, 23 Tested
Kinase Inhibition Assay from Article 10.1046/j.1432-1327.2000.01673.x: "Paullones are potent inhibitors of glycogen synthase kinase-3beta and cyclin-dependent kinase 5/p25."
Assay data:45 Active, 36 Activity ≤ 1 µM, 56 Tested
Kinase Inhibition Assay from Article 10.1016/s0960-894x(03)00651-6: "Structure-based design of 2-arylamino-4-cyclohexylmethyl-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinases 1 and 2."
Assay data:8 Active, 6 Activity ≤ 1 µM, 9 Tested
Kinase Inhibition Assay from Article 10.1021/jm0311442: "N2-substituted O6-cyclohexylmethylguanine derivatives: potent inhibitors of cyclin-dependent kinases 1 and 2."
Assay data:30 Active, 19 Activity ≤ 1 µM, 31 Tested
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