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Select item 108746391.

Hepatocyte CYR61 Polarizes Pro-Fibrotic Macrophages to Orchestrate NASH Fibrosis

Meghan Mooring, Grace A. Yeung, Panu Luukkonen, Silvia Liu, Muhammad Waqas Akbar, Gary J. Zhang, Oluwashanu Balogun, Xuemei Yu, Rigen Mo, Kari Nejak-Bowen, Masha V. Poyurovsky, Carmen J. Booth, Liza Konnikova, Gerald I. Shulman, Dean Yimlamai

Sci Transl Med. Author manuscript; available in PMC 2024 Feb 18.

Published in final edited form as: Sci Transl Med. 2023 Sep 27; 15(715): eade3157. Published online 2023 Sep 27. doi: 10.1126/scitranslmed.ade3157

PMCID:: PMC10874639

Article PDF–3.5M

Select item 93615112.

CCN1/Cyr61 Is Required in Osteoblasts for Responsiveness to the Anabolic Activity of PTH

Gexin Zhao, Elliot W Kim, Jie Jiang, Chimay Bhoot, Kemberly R Charles, Jongseung Baek, Subburaman Mohan, John S Adams, Sotirios Tetradis, Karen M Lyons

J Bone Miner Res. Author manuscript; available in PMC 2022 Aug 9.

Published in final edited form as: J Bone Miner Res. 2020 Nov; 35(11): 2289–2300. Published online 2020 Aug 17. doi: 10.1002/jbmr.4128

PMCID:: PMC9361511

Article PDF–1.5M

Select item 91668013.

CCN1 interacts with integrins to regulate intestinal stem cell proliferation and differentiation

Jong Hoon Won, Jacob S. Choi, Joon-Il Jun

Nat Commun. 2022; 13: 3117. Published online 2022 Jun 3. doi: 10.1038/s41467-022-30851-1

PMCID:: PMC9166801

Article PDF–3.7M

Select item 77899744.

Alveolar CCN1 is associated with mechanical stretch and acute respiratory distress syndrome severity

Eric D. Morrell, Serge Grazioli, Chi Hung, Osamu Kajikawa, Susanna Kosamo, Renee D. Stapleton, Sina A. Gharib, Laura Amado-Rodríguez, Guillermo Albaiceta, Mark M. Wurfel, Gustavo Matute-Bello

Am J Physiol Lung Cell Mol Physiol. 2020 Nov 1; 319(5): L825–L832. Published online 2020 Sep 16. doi: 10.1152/ajplung.00073.2020

PMCID:: PMC7789974

Article

Select item 56449875.

CRE and SRE mediate LPA-induced CCN1 transcription in mouse aortic smooth muscle cells

Quanlin Dou, Feng Hao, Longsheng Sun, Xuemin Xu, Mei-Zhen Cui

Can J Physiol Pharmacol. Author manuscript; available in PMC 2017 Oct 17.

Published in final edited form as: Can J Physiol Pharmacol. 2017 Mar; 95(3): 275–280. Published online 2016 Dec 17. doi: 10.1139/cjpp-2016-0559

PMCID:: PMC5644987

Article PDF–519K

Select item 48114886.

The matricellular protein CYR61 interferes with normal pancreatic islets architecture and promotes pancreatic neuroendocrine tumor progression

Yu-Ting Huang, Qiang Lan, Lionel Ponsonnet, Marisa Blanquet, Gerhard Christofori, Jelena Zaric, Curzio Rüegg

Oncotarget. 2016 Jan 12; 7(2): 1663–1674. Published online 2015 Nov 27. doi: 10.18632/oncotarget.6411

PMCID:: PMC4811488

Article PDF–2.7M

Select item 45833227.

The Matricellular Protein CCN1 Promotes Mucosal Healing in Murine Colitis through IL-6

Jacob S. Choi, Ki-Hyun Kim, Lester F. Lau

Mucosal Immunol. Author manuscript; available in PMC 2016 May 1.

Published in final edited form as: Mucosal Immunol. 2015 Nov; 8(6): 1285–1296. Published online 2015 Mar 25. doi: 10.1038/mi.2015.19

PMCID:: PMC4583322

Article PDF–2.1M

Select item 43988728.

CYR61 (CCN1) overexpression induces lung injury in mice

Serge Grazioli, Sucheol Gil, Dowon An, Osamu Kajikawa, Alex W. Farnand, Josiah F. Hanson, Timothy Birkland, Peter Chen, Jeremy Duffield, Lynn M. Schnapp, William A. Altemeier, Gustavo Matute-Bello

Am J Physiol Lung Cell Mol Physiol. 2015 Apr 15; 308(8): L759–L765. Published online 2015 Feb 20. doi: 10.1152/ajplung.00190.2014

PMCID:: PMC4398872

Article

Select item 43754799.

The Matricellular Protein Cyr61 Is a Key Mediator of Platelet-derived Growth Factor-induced Cell Migration

Fuqiang Zhang, Feng Hao, Dong An, Linlin Zeng, Yi Wang, Xuemin Xu, Mei-Zhen Cui

J Biol Chem. 2015 Mar 27; 290(13): 8232–8242. Published online 2015 Jan 26. doi: 10.1074/jbc.M114.623074

PMCID:: PMC4375479

Article PDF–1.8M

Select item 393764910.

Matricellular Protein Cyr61 Bridges Lysophosphatidic Acid and Integrin Pathways Leading to Cell Migration

Daniel Dongwei Wu, Fuqiang Zhang, Feng Hao, Jerold Chun, Xuemin Xu, Mei-Zhen Cui

J Biol Chem. 2014 Feb 28; 289(9): 5774–5783. Published online 2013 Dec 26. doi: 10.1074/jbc.M113.533042

PMCID:: PMC3937649

Article PDF–2.3M

Select item 357406611.

Cysteine-Rich Protein 61 Plays a Proinflammatory Role in Obstructive Kidney Fibrosis

Chun-Fu Lai, Yung-Ming Chen, Wen-Chih Chiang, Shuei-Liong Lin, Min-Liang Kuo, Tun-Jun Tsai

PLoS One. 2013; 8(2): e56481. Published online 2013 Feb 15. doi: 10.1371/journal.pone.0056481

PMCID:: PMC3574066

Article PDF–1017K

Select item 352053812.

CCN1 expression in hepatocytes contributes to macrophage infiltration in nonalcoholic fatty liver disease in mice

Zhaolian Bian, Yanshen Peng, Zhengrui You, Qixia Wang, Qi Miao, Yuan Liu, Xiaofeng Han, Dekai Qiu, Zhiping Li, Xiong Ma

J Lipid Res. 2013 Jan; 54(1): 44–54. doi: 10.1194/jlr.M026013

PMCID:: PMC3520538

Article PDF–2.9M

Select item 305903213.

The Matricellular Protein Cysteine-rich Protein 61 (CCN1/Cyr61) Enhances Physiological Adaptation of Retinal Vessels and Reduces Pathological Neovascularization Associated with Ischemic Retinopathy

Adeel Hasan, Nataliya Pokeza, Lynn Shaw, Hyun-Seung Lee, Douglas Lazzaro, Hemabindu Chintala, Daniel Rosenbaum, Maria B. Grant, Brahim Chaqour

J Biol Chem. 2011 Mar 18; 286(11): 9542–9554. Published online 2011 Jan 6. doi: 10.1074/jbc.M110.198689

PMCID:: PMC3059032

Article PDF–2.9M

Select item 291936414.

The Matricellular Protein CCN1/CYR61 Induces Fibroblast Senescence and Restricts Fibrosis in Cutaneous Wound Healing

Joon-Il Jun, Lester F. Lau

Nat Cell Biol. Author manuscript; available in PMC 2011 Jan 1.

Published in final edited form as: Nat Cell Biol. 2010 Jul; 12(7): 676–685. Published online 2010 Jun 6. doi: 10.1038/ncb2070

Correction in:: volume 12 on page 1249

PMCID:: PMC2919364

Article PDF–1.6M

Select item 181764115.

Cytotoxicity of TNFα is regulated by integrin-mediated matrix signaling

Chih-Chiun Chen, Jennifer L Young, Ricardo I Monzon, Ningyu Chen, Viktor Todorović, Lester F Lau

EMBO J. 2007 Mar 7; 26(5): 1257–1267. Published online 2007 Feb 22. doi: 10.1038/sj.emboj.7601596

PMCID:: PMC1817641

Article PDF–446K

Select item 1006924116.

Matrix-bound Cyr61/CCN1 is required to retain the properties of the bone marrow mesenchymal stem cell niche but is depleted with aging

Milos Marinkovic, Qiuxia Dai, Aaron O. Gonzalez, Olivia N. Tran, Travis J. Block, Stephen E. Harris, Adam B. Salmon, Chih-Ko Yeh, David D. Dean, Xiao-Dong Chen

Matrix Biol. Author manuscript; available in PMC 2023 Apr 3.

Published in final edited form as: Matrix Biol. 2022 Aug; 111: 108–132. Published online 2022 Jun 23. doi: 10.1016/j.matbio.2022.06.004