PMC Links for Gene (Select 20273) - PMC

Links from Gene

Items: 1 to 20 of 131

<< First< Prev

Page of 7

Select item 106283461.

Clinical and electrophysiological features of SCN8A variants causing episodic or chronic ataxia

Hang Lyu, Christian M. Boßelmann, Katrine M. Johannesen, Mahmoud Koko, Juan Dario Ortigoza-Escobar, Sergio Aguilera-Albesa, Deyanira Garcia-Navas Núñez, Tarja Linnankivi, Eija Gaily, Henriette J.A. van Ruiten, Ruth Richardson, Cornelia Betzler, Gabriella Horvath, Eva Brilstra, Niels Geerdink, Daniele Orsucci, Alessandra Tessa, Elena Gardella, Zofia Fleszar, Ludger Schöls, Holger Lerche, Rikke S. Møller, Yuanyuan Liu

eBioMedicine. 2023 Dec; 98: 104855. Published online 2023 Oct 28. doi: 10.1016/j.ebiom.2023.104855

PMCID:: PMC10628346

Article PDF–2.8M

Select item 90877412.

Social Deficits and Cerebellar Degeneration in Purkinje Cell Scn8a Knockout Mice

Xiaofan Yang, Hongqiang Yin, Xiaojing Wang, Yueqing Sun, Xianli Bian, Gaorui Zhang, Anning Li, Aihua Cao, Baomin Li, Darius Ebrahimi-Fakhari, Zhuo Yang, Miriam H. Meisler, Qiji Liu

Front Mol Neurosci. 2022; 15: 822129. Published online 2022 Apr 26. doi: 10.3389/fnmol.2022.822129

PMCID:: PMC9087741

Article PDF–3.8M

Select item 89038293.

NBI-921352, a first-in-class, Na_V1.6 selective, sodium channel inhibitor that prevents seizures in Scn8a gain-of-function mice, and wild-type mice and rats

JP Johnson, Thilo Focken, Kuldip Khakh, Parisa Karimi Tari, Celine Dube, Samuel J Goodchild, Jean-Christophe Andrez, Girish Bankar, David Bogucki, Kristen Burford, Elaine Chang, Sultan Chowdhury, Richard Dean, Gina de Boer, Shannon Decker, Christoph Dehnhardt, Mandy Feng, Wei Gong, Michael Grimwood, Abid Hasan, Angela Hussainkhel, Qi Jia, Stephanie Lee, Jenny Li, Sophia Lin, Andrea Lindgren, Verner Lofstrand, Janette Mezeyova, Rostam Namdari, Karen Nelkenbrecher, Noah Gregory Shuart, Luis Sojo, Shaoyi Sun, Matthew Taron, Matthew Waldbrook, Diana Weeratunge, Steven Wesolowski, Aaron Williams, Michael Wilson, Zhiwei Xie, Rhena Yoo, Clint Young, Alla Zenova, Wei Zhang, Alison J Cutts, Robin P Sherrington, Simon N Pimstone, Raymond Winquist, Charles J Cohen, James R Empfield

eLife. 2022; 11: e72468. Published online 2022 Mar 2. doi: 10.7554/eLife.72468

PMCID:: PMC8903829

Article PDF–2.4M

Select item 88139804.

Peri-Ictal Autonomic Control of Cardiac Function and Seizure-Induced Death

Ian C. Wenker, Elizabeth A. Blizzard, Pravin K. Wagley, Manoj K. Patel

Front Neurosci. 2021; 15: 795145. Published online 2022 Jan 21. doi: 10.3389/fnins.2021.795145

PMCID:: PMC8813980

Article PDF–3.6M

Select item 86357675.

Pathogenic in-Frame Variants in SCN8A: Expanding the Genetic Landscape of SCN8A-Associated Disease

Jennifer C. Wong, Kameryn M. Butler, Lindsey Shapiro, Jacquelyn T. Thelin, Kari A. Mattison, Kathryn B. Garber, Paula C. Goldenberg, Shobana Kubendran, G. Bradley Schaefer, Andrew Escayg

Front Pharmacol. 2021; 12: 748415. Published online 2021 Nov 17. doi: 10.3389/fphar.2021.748415

PMCID:: PMC8635767

Article PDF–2.3M

Select item 84297506.

Autistic-like behavior, spontaneous seizures, and increased neuronal excitability in a Scn8a mouse model

Jennifer C. Wong, Steven F. Grieco, Karoni Dutt, Lujia Chen, Jacquelyn T. Thelin, George Andrew S. Inglis, Shangrila Parvin, Sandra M. Garraway, Xiangmin Xu, Alan L. Goldin, Andrew Escayg

Neuropsychopharmacology. 2021 Oct; 46(11): 2011–2020. Published online 2021 Mar 3. doi: 10.1038/s41386-021-00985-9

PMCID:: PMC8429750

Article PDF–2.2M

Select item 80171647.

Mice Heterozygous for the Sodium Channel Scn8a (Nav1.6) Have Reduced Inflammatory Responses During EAE and Following LPS Challenge

Barakat Alrashdi, Bassel Dawod, Sabine Tacke, Stefanie Kuerten, Patrice D. Côté, Jean S. Marshall

Front Immunol. 2021; 12: 533423. Published online 2021 Mar 19. doi: 10.3389/fimmu.2021.533423

PMCID:: PMC8017164

Article PDF–2.6M

Select item 79828908.

Adrenergic Mechanisms of Audiogenic Seizure-Induced Death in a Mouse Model of SCN8A Encephalopathy

Eric R. Wengert, Ian C. Wenker, Elizabeth L. Wagner, Pravin K. Wagley, Ronald P. Gaykema, Jung-Bum Shin, Manoj K. Patel

Front Neurosci. 2021; 15: 581048. Published online 2021 Mar 4. doi: 10.3389/fnins.2021.581048

PMCID:: PMC7982890

Article PDF–3.6M

Select item 68529029.

Nav1.6 promotes inflammation and neuronal degeneration in a mouse model of multiple sclerosis

Barakat Alrashdi, Bassel Dawod, Andrea Schampel, Sabine Tacke, Stefanie Kuerten, Jean S. Marshall, Patrice D. Côté

J Neuroinflammation. 2019; 16: 215. Published online 2019 Nov 13. doi: 10.1186/s12974-019-1622-1

PMCID:: PMC6852902

Article PDF–2.1M

Select item 679349110.

The Sodium Channel Scn8a Is the Major Contributor to the Postnatal Developmental Increase of Sodium Current Density in Spinal Motoneurons

Kelly D. García, Leslie K. Sprunger, Miriam H. Meisler, Kurt G. Beam

J Neurosci. 1998 Jul 15; 18(14): 5234–5239. doi: 10.1523/JNEUROSCI.18-14-05234.1998

PMCID:: PMC6793491

Article PDF–136K

Select item 679318711.

Functional Analysis of the Mouse Scn8a Sodium Channel

Marianne R. Smith, Raymond D. Smith, Nicholas W. Plummer, Miriam H. Meisler, Alan L. Goldin

J Neurosci. 1998 Aug 15; 18(16): 6093–6102. doi: 10.1523/JNEUROSCI.18-16-06093.1998

PMCID:: PMC6793187

Article PDF–211K

Select item 675752512.

A Role for Phosphorylation in the Maintenance of Resurgent Sodium Current in Cerebellar Purkinje Neurons

Tina M. Grieco, Fatemeh S. Afshari, Indira M. Raman

J Neurosci. 2002 Apr 15; 22(8): 3100–3107. doi: 10.1523/JNEUROSCI.22-08-03100.2002

PMCID:: PMC6757525

Article PDF–268K

Select item 675321213.

Amyloid β-Induced Upregulation of Na_v1.6 Underlies Neuronal Hyperactivity in Tg2576 Alzheimer’s Disease Mouse Model

Roselia Ciccone, Cristina Franco, Ilaria Piccialli, Francesca Boscia, Antonella Casamassa, Valeria de Rosa, Pasquale Cepparulo, Mauro Cataldi, Lucio Annunziato, Anna Pannaccione

Sci Rep. 2019; 9: 13592. Published online 2019 Sep 19. doi: 10.1038/s41598-019-50018-1

PMCID:: PMC6753212

Article PDF–6.3M

Select item 674119414.

The Contribution of Resurgent Sodium Current to High-Frequency Firing in Purkinje Neurons: An Experimental and Modeling Study

Zayd M. Khaliq, Nathan W. Gouwens, Indira M. Raman

J Neurosci. 2003 Jun 15; 23(12): 4899–4912. doi: 10.1523/JNEUROSCI.23-12-04899.2003

PMCID:: PMC6741194

Article PDF–605K

Select item 672537715.

Robustness of Burst Firing in Dissociated Purkinje Neurons with Acute or Long-Term Reductions in Sodium Conductance

Andrew M. Swensen, Bruce P. Bean

J Neurosci. 2005 Apr 6; 25(14): 3509–3520. doi: 10.1523/JNEUROSCI.3929-04.2005

PMCID:: PMC6725377

Article PDF–556K

Select item 672486816.

Physiological Maturation of Photoreceptors Depends on the Voltage-Gated Sodium Channel Na_V1.6 (Scn8a)

Patrice D. Côté, Yves De Repentigny, Stuart G. Coupland, Yannick Schwab, Michel J. Roux, S. Rock Levinson, Rashmi Kothary

J Neurosci. 2005 May 18; 25(20): 5046–5050. doi: 10.1523/JNEUROSCI.4692-04.2005

PMCID:: PMC6724868

Article PDF–318K

Select item 667393217.

Impaired Firing and Cell-Specific Compensation in Neurons Lacking Na_v1.6 Sodium Channels

Audra Van Wart, Gary Matthews

J Neurosci. 2006 Jul 5; 26(27): 7172–7180. doi: 10.1523/JNEUROSCI.1101-06.2006

PMCID:: PMC6673932

Article PDF–628K

Select item 667310018.

Nav1.6 Sodium Channels Are Critical to Pacemaking and Fast Spiking in Globus Pallidus Neurons

Jeff N. Mercer, C. Savio Chan, Tatiana Tkatch, Joshua Held, D. James Surmeier

J Neurosci. 2007 Dec 5; 27(49): 13552–13566. doi: 10.1523/JNEUROSCI.3430-07.2007

PMCID:: PMC6673100

Article PDF–3.5M

Select item 657918519.

A Missense Mutation in the Sodium Channel Scn8a Is Responsible for Cerebellar Ataxia in the Mouse Mutant jolting

David C. Kohrman, Marianne R. Smith, Alan L. Goldin, John Harris, Miriam H. Meisler

J Neurosci. 1996 Oct 1; 16(19): 5993–5999. doi: 10.1523/JNEUROSCI.16-19-05993.1996

Correction in:: J Neurosci. 2013 Mar 13; 33(11): 5079.

PMCID:: PMC6579185

Article PDF–383K

Select item 614281420.

The novel sodium channel modulator GS-458967 (GS967) is an effective treatment in a mouse model of SCN8A encephalopathy

Erin M. Baker, Christopher H. Thompson, Nicole A. Hawkins, Jacy L. Wagnon, Eric R. Wengert, Manoj K. Patel, Alfred L. George, Jr., Miriam H. Meisler, Jennifer A. Kearney

Epilepsia. Author manuscript; available in PMC 2019 Jun 1.

Published in final edited form as: Epilepsia. 2018 Jun; 59(6): 1166–1176. Published online 2018 May 21. doi: 10.1111/epi.14196

PMCID:: PMC6142814

Article PDF–1.1M

PMC

Result Filters

Article attributes

Text availability

Publication date

Custom date range

Research Funder

Additional filters

Display Settings:

Send to:

Links from Gene

Items: 1 to 20 of 131

Display Settings:

Send to:

Supplemental Content

Find related data

Recent activity