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Select item 75815791.

Genetic Inactivation of Two-Pore Channel 1 Impairs Spatial Learning and Memory

Robert Theodor Mallmann, Norbert Klugbauer

Behav Genet. 2020; 50(6): 401–410. Published online 2020 Sep 5. doi: 10.1007/s10519-020-10011-1

PMCID:: PMC7581579

Article PDF–1.9M

Select item 46481982.

Inhibition of NAADP signalling on reperfusion protects the heart by preventing lethal calcium oscillations via two-pore channel 1 and opening of the mitochondrial permeability transition pore

Sean M. Davidson, Kirsty Foote, Suma Kunuthur, Raj Gosain, Noah Tan, Richard Tyser, Yong Juan Zhao, Richard Graeff, A. Ganesan, Michael R. Duchen, Sandip Patel, Derek M. Yellon

Cardiovasc Res. 2015 Dec 1; 108(3): 357–366. Published online 2015 Sep 22. doi: 10.1093/cvr/cvv226

PMCID:: PMC4648198

Article PDF–737K

Select item 39528623.

NAADP and the two-pore channel protein 1 participate in the acrosome reaction in mammalian spermatozoa

Lilli Arndt, Jan Castonguay, Elisabeth Arlt, Dorke Meyer, Sami Hassan, Heike Borth, Susanna Zierler, Gunther Wennemuth, Andreas Breit, Martin Biel, Christian Wahl-Schott, Thomas Gudermann, Norbert Klugbauer, Ingrid Boekhoff

Mol Biol Cell. 2014 Mar 15; 25(6): 948–964. doi: 10.1091/mbc.E13-09-0523

PMCID:: PMC3952862

Article PDF–1.9M

Select item 93129044.

Unexpected Motherhood-Triggered Hearing Loss in the Two-Pore Channel (TPC) Mutant Mouse

Juliette Royer, José-Manuel Cancela, Jean-Marc Edeline

Biomedicines. 2022 Jul; 10(7): 1708. Published online 2022 Jul 15. doi: 10.3390/biomedicines10071708

PMCID:: PMC9312904

Article PDF–1.3M

Select item 66797165.

Hippocampal mGluR1-dependent long-term potentiation requires NAADP-mediated acidic store Ca²⁺ signaling

William J. Foster, Henry B. C. Taylor, Zahid Padamsey, Alexander F. Jeans, Antony Galione, Nigel J. Emptage

Sci Signal. Author manuscript; available in PMC 2019 Aug 3.

Published in final edited form as: Sci Signal. 2018 Nov 27; 11(558): eaat9093. Published online 2018 Nov 27. doi: 10.1126/scisignal.aat9093

PMCID:: PMC6679716

Article PDF–2.3M

Select item 58868046.

Structural insights into the voltage and phospholipid activation of mammalian TPC1 channel

Ji She, Jiangtao Guo, Qingfeng Chen, Weizhong Zeng, Youxing Jiang, Xiao-chen Bai

Nature. Author manuscript; available in PMC 2018 Sep 21.

Published in final edited form as: Nature. 2018 Apr 5; 556(7699): 130–134. Published online 2018 Mar 21. doi: 10.1038/nature26139

PMCID:: PMC5886804

Article PDF–2.4M

Select item 48876847.

Endolysosomal two‐pore channels regulate autophagy in cardiomyocytes

Vanessa García‐Rúa, Sandra Feijóo‐Bandín, Diego Rodríguez‐Penas, Ana Mosquera‐Leal, Emad Abu‐Assi, Andrés Beiras, Luisa María Seoane, Pamela Lear, John Parrington, Manuel Portolés, Esther Roselló‐Lletí, Miguel Rivera, Oreste Gualillo, Valentina Parra, Joseph A. Hill, Beverly Rothermel, José Ramón González‐Juanatey, Francisca Lago

J Physiol. 2016 Jun 1; 594(11): 3061–3077. Published online 2016 Feb 4. doi: 10.1113/JP271332

PMCID:: PMC4887684

Article PDF–1.1M

Select item 47059688.

Two-pore Channels (TPC2s) and Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) at Lysosomal-Sarcoplasmic Reticular Junctions Contribute to Acute and Chronic β-Adrenoceptor Signaling in the Heart

Rebecca A. Capel, Emma L. Bolton, Wee K. Lin, Daniel Aston, Yanwen Wang, Wei Liu, Xin Wang, Rebecca-Ann B. Burton, Duncan Bloor-Young, Kai-Ting Shade, Margarida Ruas, John Parrington, Grant C. Churchill, Ming Lei, Antony Galione, Derek A. Terrar

J Biol Chem. 2015 Dec 11; 290(50): 30087–30098. Published online 2015 Oct 5. doi: 10.1074/jbc.M115.684076

PMCID:: PMC4705968

Article PDF–2.3M

Select item 45718669.

Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Endolysosomal Two-pore Channels Modulate Membrane Excitability and Stimulus-Secretion Coupling in Mouse Pancreatic β Cells

Abdelilah Arredouani, Margarida Ruas, Stephan C. Collins, Raman Parkesh, Frederick Clough, Toby Pillinger, George Coltart, Katja Rietdorf, Andrew Royle, Paul Johnson, Matthias Braun, Quan Zhang, William Sones, Kenju Shimomura, Anthony J. Morgan, Alexander M. Lewis, Kai-Ting Chuang, Ruth Tunn, Joaquin Gadea, Lydia Teboul, Paula M. Heister, Patricia W. Tynan, Elisa A. Bellomo, Guy A. Rutter, Patrik Rorsman, Grant C. Churchill, John Parrington, Antony Galione

J Biol Chem. 2015 Aug 28; 290(35): 21376–21392. Published online 2015 Jul 7. doi: 10.1074/jbc.M115.671248

PMCID:: PMC4571866

Article PDF–3.6M

Select item 451642810.

Expression of Ca²⁺-permeable two-pore channels rescues NAADP signalling in TPC-deficient cells

Margarida Ruas, Lianne C Davis, Cheng-Chang Chen, Anthony J Morgan, Kai-Ting Chuang, Timothy F Walseth, Christian Grimm, Clive Garnham, Trevor Powell, Nick Platt, Frances M Platt, Martin Biel, Christian Wahl-Schott, John Parrington, Antony Galione

EMBO J. 2015 Jul 2; 34(13): 1743–1758. Published online 2015 Apr 14. doi: 10.15252/embj.201490009

PMCID:: PMC4516428

Article PDF–1.8M

Select item 438645511.

TPC1 Has Two Variant Isoforms, and Their Removal Has Different Effects on Endo-Lysosomal Functions Compared to Loss of TPC2

Margarida Ruas, Kai-Ting Chuang, Lianne C. Davis, Areej Al-Douri, Patricia W. Tynan, Ruth Tunn, Lydia Teboul, Antony Galione, John Parrington

Mol Cell Biol. 2014 Nov; 34(21): 3981–3992. doi: 10.1128/MCB.00113-14

PMCID:: PMC4386455

Article PDF–2.6M

Select item 433031712.

Absence of Intracellular Ion Channels TPC1 and TPC2 Leads to Mature-Onset Obesity in Male Mice, Due to Impaired Lipid Availability for Thermogenesis in Brown Adipose Tissue

Pamela V. Lear, David González-Touceda, Begoña Porteiro Couto, Patricia Viaño, Vanessa Guymer, Elena Remzova, Ruth Tunn, Annapurna Chalasani, Tomás García-Caballero, Iain P. Hargreaves, Patricia W. Tynan, Helen C. Christian, Rubén Nogueiras, John Parrington, Carlos Diéguez

Endocrinology. 2015 Mar; 156(3): 975–986. Published online 2014 Dec 29. doi: 10.1210/en.2014-1766

PMCID:: PMC4330317

Article

Select item 271973413.

The two-pore channel TPCN2 mediates NAADP-dependent Ca²⁺-release from lysosomal stores

Xiangang Zong, Michael Schieder, Hartmut Cuny, Stefanie Fenske, Christian Gruner, Katrin Rötzer, Oliver Griesbeck, Hartmann Harz, Martin Biel, Christian Wahl-Schott

Pflugers Arch. 2009 Sep; 458(5): 891–899. Published online 2009 Jun 26. doi: 10.1007/s00424-009-0690-y

PMCID:: PMC2719734

Article PDF–408K

Select item 736096714.

NAADP‐regulated two‐pore channels drive phagocytosis through endo‐lysosomal Ca²⁺ nanodomains, calcineurin and dynamin

Lianne C Davis, Anthony J Morgan, Antony Galione

EMBO J. 2020 Jul 15; 39(14): e104058. Published online 2020 Jun 8. doi: 10.15252/embj.2019104058

PMCID:: PMC7360967

Article PDF–4.9M

Select item 557714515.

The two-pore channel TPC1 is required for efficient protein processing through early and recycling endosomes

Jan Castonguay, Joachim H. C. Orth, Thomas Müller, Faten Sleman, Christian Grimm, Christian Wahl-Schott, Martin Biel, Robert Theodor Mallmann, Wolfgang Bildl, Uwe Schulte, Norbert Klugbauer

Sci Rep. 2017; 7: 10038. Published online 2017 Aug 30. doi: 10.1038/s41598-017-10607-4

PMCID:: PMC5577145

Article PDF–4.1M

Select item 455058716.

Two pore channels control Ebolavirus host cell entry and are drug targets for disease treatment

Yasuteru Sakurai, Andrey A. Kolokoltsov, Cheng-Chang Chen, Michael W. Tidwell, William E. Bauta, Norbert Klugbauer, Christian Grimm, Christian Wahl-Schott, Martin Biel, Robert A. Davey

Science. Author manuscript; available in PMC 2016 Feb 27.

Published in final edited form as: Science. 2015 Feb 27; 347(6225): 995–998. doi: 10.1126/science.1258758

PMCID:: PMC4550587

Article PDF–724K

Select item 351629817.

PRESENILIN-NULL CELLS HAVE ALTERED TWO-PORE CALCIUM CHANNEL EXPRESSION AND LYSOSOMAL CALCIUM; IMPLICATIONS FOR LYSOSOMAL FUNCTION

Kara M Neely Kayala, George D Dickinson, Anet Minassian, Ken C Walls, Kim N Green, Frank M LaFerla

Brain Res. Author manuscript; available in PMC 2013 Dec 13.

Published in final edited form as: Brain Res. 2012 Dec 13; 1489: 8–16. Published online 2012 Oct 24. doi: 10.1016/j.brainres.2012.10.036

PMCID:: PMC3516298

Article PDF–1.7M

Select item 811871218.

Lipid-gated monovalent ion fluxes regulate endocytic traffic and support immune surveillance

Spencer A. Freeman, Stefan Uderhardt, Amra Saric, Richard F. Collins, Catherine M. Buckley, Sivakami Mylvaganam, Parastoo Boroumand, Jonathan Plumb, Ronald N. Germain, Dejian Ren, Sergio Grinstein

Science. Author manuscript; available in PMC 2021 May 13.

Published in final edited form as: Science. 2020 Jan 17; 367(6475): 301–305. Published online 2019 Dec 5. doi: 10.1126/science.aaw9544

PMCID:: PMC8118712

Article PDF–1.5M

Select item 347518619.

TPC Proteins Are Phosphoinositide-activated Sodium-selective Ion Channels in Endosomes and Lysosomes

Xiang Wang, Xiaoli Zhang, Xian-ping Dong, Mohammad Samie, Xinran Li, Xiping Cheng, Andrew Goschka, Dongbiao Shen, Yandong Zhou, Janice Harlow, Michael X. Zhu, David E. Clapham, Dejian Ren, Haoxing Xu

Cell. Author manuscript; available in PMC 2013 Oct 12.

Published in final edited form as: Cell. 2012 Oct 12; 151(2): 372–383. doi: 10.1016/j.cell.2012.08.036

PMCID:: PMC3475186

Article PDF–3.4M

Select item 422609920.

VEGF-induced neoangiogenesis is mediated by NAADP and two-pore channel-2–dependent Ca²⁺ signaling

Annarita Favia, Marianna Desideri, Guido Gambara, Alessio D’Alessio, Margarida Ruas, Bianca Esposito, Donatella Del Bufalo, John Parrington, Elio Ziparo, Fioretta Palombi, Antony Galione, Antonio Filippini

Proc Natl Acad Sci U S A. 2014 Nov 4; 111(44): E4706–E4715. Published online 2014 Oct 20. doi: 10.1073/pnas.1406029111

PMCID:: PMC4226099

Article PDF–1.6M

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