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Select item 106946051.

Hypoxia-driven protease legumain promotes immunosuppression in glioblastoma

Lizhi Pang, Songlin Guo, Fatima Khan, Madeline Dunterman, Heba Ali, Yang Liu, Yuyun Huang, Peiwen Chen

Cell Rep Med. 2023 Nov 21; 4(11): 101238. Published online 2023 Oct 18. doi: 10.1016/j.xcrm.2023.101238

PMCID:: PMC10694605

Article PDF–8.1M

Select item 101129292.

Maf family transcription factors are required for nutrient uptake in the mouse neonatal gut

Anne M. Bara, Lei Chen, Celina Ma, Julie Underwood, Rebecca S. Moreci, Kaelyn Sumigray, Tongyu Sun, Yarui Diao, Michael Verzi, Terry Lechler

Development. 2022 Dec 1; 149(23): dev201251. Published online 2022 Dec 12. doi: 10.1242/dev.201251

PMCID:: PMC10112929

Article

Select item 88815813.

Asparaginyl endopeptidase protects against podocyte injury in diabetic nephropathy through cleaving cofilin-1

Chuntao Lei, Mengran Li, Yang Qiu, Yaru Xie, Zhe Hao, Xingjie Yin, Zhentao Zhang, Hua Su, Linlin Yang, Jihong Lin, Hans-Peter Hammes, Chun Zhang

Cell Death Dis. 2022 Feb; 13(2): 184. Published online 2022 Feb 25. doi: 10.1038/s41419-022-04621-2

PMCID:: PMC8881581

Article PDF–12M

Select item 84086104.

Gut inflammation triggers C/EBPβ/δ‐secretase‐dependent gut‐to‐brain propagation of Aβ and Tau fibrils in Alzheimer’s disease

Chun Chen, Yunzhe Zhou, Hualong Wang, Ashfaqul Alam, Seong Su Kang, Eun Hee Ahn, Xia Liu, Jianping Jia, Keqiang Ye

EMBO J. 2021 Sep 1; 40(17): e106320. Published online 2021 Jul 14. doi: 10.15252/embj.2020106320

PMCID:: PMC8408610

Article PDF–5.0M

Select item 79387705.

BraInMap elucidates the macromolecular connectivity landscape of mammalian brain

Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili

Cell Syst. Author manuscript; available in PMC 2021 Apr 22.

Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003

Correction in:: Cell Syst. 2020 Aug 26; 11(2): 208.

PMCID:: PMC7938770

Article PDF–2.0M

Select item 77862166.

Legumain Induces Oral Cancer Pain by Biased Agonism of Protease-Activated Receptor-2

Nguyen Huu Tu, Dane D. Jensen, Bethany M. Anderson, Elyssa Chen, Nestor N. Jimenez-Vargas, Nicole N. Scheff, Kenji Inoue, Hung D. Tran, John C. Dolan, Tamaryn A. Meek, Morley D. Hollenberg, Cheng Z. Liu, Stephen J. Vanner, Malvin N. Janal, Nigel W. Bunnett, Laura E. Edgington-Mitchell, Brian L. Schmidt

J Neurosci. 2021 Jan 6; 41(1): 193–210. doi: 10.1523/JNEUROSCI.1211-20.2020

PMCID:: PMC7786216

Article PDF–5.4M

Select item 76147797.

Perforin-2 is a pore-forming effector of endocytic escape in cross-presenting dendritic cells

Pablo Rodríguez-Silvestre, Marco Laub, Patrycja A. Krawczyk, Alexandra K. Davies, Julia P. Schessner, Reejuana Parveen, Benjamin J. Tuck, William A. McEwan, Georg H.H. Borner, Patrycja Kozik

Science. Author manuscript; available in PMC 2023 Jul 19.

Published in final edited form as: Science. 2023 Jun 23; 380(6651): 1258–1265. Published online 2023 Jun 22. doi: 10.1126/science.adg8802

PMCID:: PMC7614779

Article PDF–1.8M

Select item 63108558.

Spatiotemporal activation of the C/EBPβ/δ-secretase axis regulates the pathogenesis of Alzheimer’s disease

Hualong Wang, Xia Liu, Shengdi Chen, Keqiang Ye

Proc Natl Acad Sci U S A. 2018 Dec 26; 115(52): E12427–E12434. Published online 2018 Dec 10. doi: 10.1073/pnas.1815915115

Correction in:: Proc Natl Acad Sci U S A. 2019 Dec 17; 116(51): 26090.

PMCID:: PMC6310855

Article PDF–1.5M

Select item 62980409.

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors

Hyeonwoo Kim, Christiane D. Wrann, Mark Jedrychowski, Sara Vidoni, Yukiko Kitase, Kenichi Nagano, Chenhe Zhou, Joshua Chou, Virginia-Jeni A. Parkman, Scott J. Novick, Timothy S. Strutzenberg, Bruce D. Pascal, Phuong T. Le, Daniel J. Brooks, Alexander M. Roche, Kaitlyn K. Gerber, Laura Mattheis, Wenjing Chen, Hua Tu, Mary L. Bouxsein, Patrick R. Griffin, Roland Baron, Clifford J. Rosen, Lynda F. Bonewald, Bruce M. Spiegelman

Cell. Author manuscript; available in PMC 2019 Dec 13.

Published in final edited form as: Cell. 2018 Dec 13; 175(7): 1756–1768.e17. doi: 10.1016/j.cell.2018.10.025

Correction in:: Cell. 2019 Jul 11; 178(2): 507–508.

PMCID:: PMC6298040

Article PDF–1.2M

Select item 629722610.

Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-dependent pathway of lysosomal homeostasis

Jonathan Martínez-Fábregas, Alan Prescott, Sander van Kasteren, Deena Leslie Pedrioli, Irwin McLean, Anna Moles, Thomas Reinheckel, Valeria Poli, Colin Watts

Nat Commun. 2018; 9: 5343. Published online 2018 Dec 17. doi: 10.1038/s41467-018-07741-6

PMCID:: PMC6297226

Article PDF–3.4M

Select item 627940111.

Delta-secretase (AEP) mediates tau-splicing imbalance and accelerates cognitive decline in tauopathies

Zhi-Hao Wang, Pai Liu, Xia Liu, Shan Ping Yu, Jian-Zhi Wang, Keqiang Ye

J Exp Med. 2018 Dec 3; 215(12): 3038–3056. doi: 10.1084/jem.20180539

PMCID:: PMC6279401

Article PDF–4.0M

Select item 626277712.

LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow

Hui-yuan Tseng, Anna V. Samarelli, Patricia Kammerer, Sarah Scholze, Tilman Ziegler, Roland Immler, Roy Zent, Markus Sperandio, Charles R. Sanders, Reinhard Fässler, Ralph T. Böttcher

J Cell Sci. 2018 Nov 15; 131(22): jcs218214. Published online 2018 Nov 21. doi: 10.1242/jcs.218214

PMCID:: PMC6262777

Article

Select item 614117813.

BDNF inhibits neurodegenerative disease–associated asparaginyl endopeptidase activity via phosphorylation by AKT

Zhi-Hao Wang, Wanqiang Wu, Seong Su Kang, Xia Liu, Zhiping Wu, Junmin Peng, Shan Ping Yu, Fredric P. Manfredsson, Ivette M. Sandoval, Xuebo Liu, Jian-Zhi Wang, Keqiang Ye

JCI Insight. 2018 Aug 23; 3(16): e99007. Published online 2018 Aug 23. doi: 10.1172/jci.insight.99007

PMCID:: PMC6141178

Article PDF–4.3M

Select item 601507914.

TLR9 activation via microglial glucocorticoid receptors contributes to degeneration of midbrain dopamine neurons

Layal Maatouk, Anne-Claire Compagnion, Maria-Angeles Carrillo-de Sauvage, Alexis-Pierre Bemelmans, Sabrina Leclere-Turbant, Vincent Cirotteau, Mira Tohme, Allen Beke, Michaël Trichet, Virginie Bazin, Bobby N. Trawick, Richard M. Ransohoff, François Tronche, Bénédicte Manoury, Sheela Vyas

Nat Commun. 2018; 9: 2450. Published online 2018 Jun 22. doi: 10.1038/s41467-018-04569-y

Correction in:: Nat Commun. 2018; 9: 3109.

PMCID:: PMC6015079

Article PDF–4.4M

Select item 600365015.

α‐Synuclein stimulation of monoamine oxidase‐B and legumain protease mediates the pathology of Parkinson's disease

Seong Su Kang, Eun Hee Ahn, Zhentao Zhang, Xia Liu, Fredric P Manfredsson, Ivette M Sandoval, Susov Dhakal, P Michael Iuvone, Xuebing Cao, Keqiang Ye

EMBO J. 2018 Jun 15; 37(12): e98878. Published online 2018 May 16. doi: 10.15252/embj.201798878

PMCID:: PMC6003650

Article PDF–2.9M

Select item 531242716.

Legumain Regulates Differentiation Fate of Human Bone Marrow Stromal Cells and Is Altered in Postmenopausal Osteoporosis

Abbas Jafari, Diyako Qanie, Thomas L. Andersen, Yuxi Zhang, Li Chen, Benno Postert, Stuart Parsons, Nicholas Ditzel, Sundeep Khosla, Harald Thidemann Johansen, Per Kjærsgaard-Andersen, Jean-Marie Delaisse, Basem M. Abdallah, Daniel Hesselson, Rigmor Solberg, Moustapha Kassem

Stem Cell Reports. 2017 Feb 14; 8(2): 373–386. Published online 2017 Feb 2. doi: 10.1016/j.stemcr.2017.01.003

PMCID:: PMC5312427

Article PDF–3.8M

Select item 529582117.

High-throughput discovery of novel developmental phenotypes

Mary E. Dickinson, Ann M. Flenniken, Xiao Ji, Lydia Teboul, Michael D. Wong, Jacqueline K. White, Terrence F. Meehan, Wolfgang J. Weninger, Henrik Westerberg, Hibret Adissu, Candice N. Baker, Lynette Bower, James M. Brown, L. Brianna Caddle, Francesco Chiani, Dave Clary, James Cleak, Mark J. Daly, James M. Denegre, Brendan Doe, Mary E. Dolan, Sarah M. Edie, Helmut Fuchs, Valerie Gailus-Durner, Antonella Galli, Alessia Gambadoro, Juan Gallegos, Shiying Guo, Neil R. Horner, Chih-wei Hsu, Sara J. Johnson, Sowmya Kalaga, Lance C. Keith, Louise Lanoue, Thomas N. Lawson, Monkol Lek, Manuel Mark, Susan Marschall, Jeremy Mason, Melissa L. McElwee, Susan Newbigging, Lauryl M.J. Nutter, Kevin A. Peterson, Ramiro Ramirez-Solis, Douglas J. Rowland, Edward Ryder, Kaitlin E. Samocha, John R. Seavitt, Mohammed Selloum, Zsombor Szoke-Kovacs, Masaru Tamura, Amanda G Trainor, Ilinca Tudose, Shigeharu Wakana, Jonathan Warren, Olivia Wendling, David B. West, Leeyean Wong, Atsushi Yoshiki, The International Mouse Phenotyping Consortium, Daniel G. MacArthur, Glauco P. Tocchini-Valentini, Xiang Gao, Paul Flicek, Allan Bradley, William C. Skarnes, Monica J. Justice, Helen E. Parkinson, Mark Moore, Sara Wells, Robert E. Braun, Karen L. Svenson, Martin Hrabe de Angelis, Yann Herault, Tim Mohun, Ann-Marie Mallon, R. Mark Henkelman, Steve D.M. Brown, David J. Adams, K.C. Kent Lloyd, Colin McKerlie, Arthur L. Beaudet, Maja Bucan, Stephen A. Murray

Nature. Author manuscript; available in PMC 2017 Mar 14.

Published in final edited form as: Nature. 2016 Sep 22; 537(7621): 508–514. Published online 2016 Sep 14. doi: 10.1038/nature19356

Correction in:: Nature. 2017 Nov 16; 551(7680): 398.

PMCID:: PMC5295821

Article PDF–3.0M

Select item 507599918.

Legumain is activated in macrophages during pancreatitis

Laura E. Edgington-Mitchell, Thomas Wartmann, Alicia K. Fleming, Vasilena Gocheva, Wouter A. van der Linden, Nimali P. Withana, Martijn Verdoes, Luigi Aurelio, Daniel Edgington-Mitchell, TinaMarie Lieu, Belinda S. Parker, Bim Graham, Thomas Reinheckel, John B. Furness, Johanna A. Joyce, Peter Storz, Walter Halangk, Matthew Bogyo, Nigel W. Bunnett

Am J Physiol Gastrointest Liver Physiol. 2016 Sep 1; 311(3): G548–G560. Published online 2016 Aug 11. doi: 10.1152/ajpgi.00047.2016

PMCID:: PMC5075999

Article

Select item 465994019.

Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer's disease

Zhentao Zhang, Mingke Song, Xia Liu, Seong Su Kang, Duc M. Duong, Nicholas T. Seyfried, Xuebing Cao, Liming Cheng, Yi E. Sun, Shan Ping Yu, Jianping Jia, Allan I. Levey, Keqiang Ye

Nat Commun. 2015; 6: 8762. Published online 2015 Nov 9. doi: 10.1038/ncomms9762

PMCID:: PMC4659940

Article PDF–4.9M

Select item 431955920.

A high resolution spatiotemporal atlas of gene expression of the developing mouse brain

Carol L. Thompson, Lydia Ng, Vilas Menon, Salvador Martinez, Chang-Kyu Lee, Katie Glattfelder, Susan M. Sunkin, Alex Henry, Christopher Lau, Chinh Dang, Raquel Garcia-Lopez, Almudena Martinez-Ferre, Ana Pombero, John L.R. Rubenstein, Wayne B. Wakeman, John Hohmann, Nick Dee, Andrew J. Sodt, Rob Young, Kimberly Smith, Thuc-Nghi Nguyen, Jolene Kidney, Leonard Kuan, Andreas Jeromin, Ajamete Kaykas, Jeremy Miller, Damon Page, Geri Orta, Amy Bernard, Zackery Riley, Simon Smith, Paul Wohnoutka, Mike Hawrylycz, Luis Puelles, Allan R. Jones

Neuron. Author manuscript; available in PMC 2015 Jul 16.

Published in final edited form as: Neuron. 2014 Jul 16; 83(2): 309–323. Published online 2014 Jun 19. doi: 10.1016/j.neuron.2014.05.033

PMCID:: PMC4319559

Article PDF–3.0M

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