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Select item 91644391.

Intranasal pediatric parainfluenza virus-vectored SARS-CoV-2 vaccine candidate is protective in macaques

Cyril Le Nouën, Christine E. Nelson, Xueqiao Liu, Hong-Su Park, Yumiko Matsuoka, Cindy Luongo, Celia Santos, Lijuan Yang, Richard Herbert, Ashley Castens, Ian N. Moore, Temeri Wilder-Kofie, Rashida Moore, April Walker, Peng Zhang, Paolo Lusso, Reed F. Johnson, Nicole L. Garza, Laura E. Via, Shirin Munir, Daniel Barber, Ursula J. Buchholz

Version 1. bioRxiv. Preprint. 2022 May 23. doi: 10.1101/2022.05.21.492923

Published in:: Proc Natl Acad Sci U S A. 2021 Dec 14; 118(50): e2109744118.

PMCID:: PMC9164439

Article PDF–4.7M

Select item 81830052.

SARS-CoV-2 Spreads through Cell-to-Cell Transmission

Cong Zeng, John P. Evans, Tiffany King, Yi-Min Zheng, Eugene M. Oltz, Sean P. J. Whelan, Linda Saif, Mark E. Peeples, Shan-Lu Liu

Version 1. bioRxiv. Preprint. 2021 Jun 1. doi: 10.1101/2021.06.01.446579

Published in:: Proc Natl Acad Sci U S A. 2022 Jan 4; 119(1): e2111400119.

PMCID:: PMC8183005

Abstract Article PDF–19M

Select item 97742223.

Live-attenuated pediatric parainfluenza vaccine expressing 6P-stabilized SARS-CoV-2 spike protein is protective against SARS-CoV-2 variants in hamsters

Xueqiao Liu, Hong-Su Park, Yumiko Matsuoka, Celia Santos, Lijuan Yang, Cindy Luongo, Ian N. Moore, Reed F. Johnson, Nicole L. Garza, Peng Zhang, Paolo Lusso, Sonja M. Best, Ursula J. Buchholz, Cyril Le Nouën

Version 1. bioRxiv. Preprint. 2022 Dec 13. doi: 10.1101/2022.12.12.520032

Published in:: PLoS Pathog. 2023 Jun; 19(6): e1011057.

PMCID:: PMC9774222

Article PDF–2.5M

Select item 100813084.

S:D614G and S:H655Y are gateway mutations that act epistatically to promote SARS-CoV-2 variant fitness

Leonid Yurkovetskiy, Shawn Egri, Chaitanya Kurhade, Marco A. Diaz-Salinas, Javier A. Jaimes, Thomas Nyalile, Xuping Xie, Manish C. Choudhary, Ann Dauphin, Jonathan Z. Li, James B. Munro, Pei-Yong Shi, Kuang Shen, Jeremy Luban

Version 2. bioRxiv. Preprint. 2023 Mar 31 [revised 2023 Apr 24]. doi: 10.1101/2023.03.30.535005

PMCID:: PMC10081308

Article PDF–6.7M

Select item 108888265.

A Broad-Spectrum Multi-Antigen mRNA/LNP-Based Pan-Coronavirus Vaccine Induced Potent Cross-Protective Immunity Against Infection and Disease Caused by Highly Pathogenic and Heavily Spike-Mutated SARS-CoV-2 Variants of Concern in the Syrian Hamster Model

Swayam Prakash, Nisha R. Dhanushkodi, Mahmoud Singer, Afshana Quadiri, Latifa Zayou, Hawa Vahed, Pierre-Gregoire Coulon, Izabela Coimbra Ibraim, Christine Tafoya, Lauren Hitchcock, Gary Landucci, Donald N. Forthal, Assia El Babsiri, Delia F. Tifrea, Cesar J. Figueroa, Anthony B. Nesburn, Baruch D. Kuppermann, Daniel Gil, Trevor M. Jones, Jeffrey B. Ulmer, Lbachir BenMohamed

Version 1. bioRxiv. Preprint. 2024 Feb 15. doi: 10.1101/2024.02.14.580225

PMCID:: PMC10888826

Article PDF–4.6M

Select item 74576136.

A comparative analysis of SARS-CoV-2 antivirals in human airway models characterizes 3CL^pro inhibitor PF-00835231 as a potential new treatment for COVID-19

Maren de Vries, Adil S Mohamed, Rachel A Prescott, Ana M Valero-Jimenez, Ludovic Desvignes, Rebecca O’Connor, Claire Steppan, Joseph C Devlin, Ellie Ivanova, Alberto Herrera, Austin Schinlever, Paige Loose, Kelly Ruggles, Sergei B Koralov, Annaliesa S. Anderson, Joseph Binder, Meike Dittmann

Version 2. bioRxiv. Preprint. 2020 Aug 28 [revised 2021 Feb 19]. doi: 10.1101/2020.08.28.272880

Published in:: J Virol. 2021 May; 95(10): e01819-20.

PMCID:: PMC7457613

Abstract Article PDF–1.6M

Select item 91961097.

Efficacy of Parainfluenza Virus 5 (PIV5)-vectored Intranasal COVID-19 Vaccine as a Single Dose Vaccine and as a Booster against SARS-CoV-2 Variants

Ashley C. Beavis, Zhuo Li, Kelsey Briggs, María Cristina Huertas-Díaz, Elizabeth R. Wrobel, Maria Najera, Dong An, Nichole Orr-Burks, Jackelyn Murray, Preetish Patil, Jiachen Huang, Jarrod Mousa, Linhui Hao, Tien-Ying Hsiang, Michael Gale, Jr., Stephen B. Harvey, S. Mark Tompkins, Robert Jeffrey Hogan, Eric R. Lafontaine, Hong Jin, Biao He

Version 1. bioRxiv. Preprint. 2022 Jun 8. doi: 10.1101/2022.06.07.495215

PMCID:: PMC9196109

Article PDF–4.5M

Select item 80209978.

Maternal-Fetal Immune Responses in Pregnant Women Infected with SARS-CoV-2

Valeria Garcia-Flores, Roberto Romero, Yi Xu, Kevin Theis, Marcia Arenas-Hernandez, Derek Miller, Azam Peyvandipour, Jose Galaz, Dustyn Levenson, Gaurav Bhatti, Meyer Gershater, Errile Pusod, David Kracht, Violetta Florova, Yaozhu Leng, Li Tao, Megan Faucett, Robert Para, Chaur-Dong Hsu, Gary Zhang, Adi L. Tarca, Roger Pique-Regi, Nardhy Gomez-Lopez

Version 1. Res Sq. Preprint. 2021 Mar 31. doi: 10.21203/rs.3.rs-362886/v1

Published in:: Nat Commun. 2022; 13: 320.

PMCID:: PMC8020997

Abstract Article PDF–5.0M

Select item 79416179.

Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell

Maritza Puray-Chavez, Kyle M. LaPak, Travis P. Schrank, Jennifer L. Elliott, Dhaval P. Bhatt, Megan J. Agajanian, Ria Jasuja, Dana Q. Lawson, Keanu Davis, Paul W. Rothlauf, Heejoon Jo, Nakyung Lee, Kasyap Tenneti, Jenna E. Eschbach, Christian Shema Mugisha, Hung R. Vuong, Adam L. Bailey, D. Neil Hayes, Sean P.J. Whelan, Amjad Horani, Steven L. Brody, Dennis Goldfarb, M. Ben Major, Sebla B. Kutluay

Version 1. bioRxiv. Preprint. 2021 Mar 1. doi: 10.1101/2021.03.01.433431

Published in:: Cell Rep. 2021 Jul 13; 36(2): 109364.

PMCID:: PMC7941617

Abstract Article PDF–4.1M

Select item 1046207110.

Impact of age and sex on neuroinflammation following SARS-CoV-2 infection in a murine model

Venkatramana D. Krishna, Allison Chang, Holly Korthas, Susanna R. Var, Walter C. Low, Ling Li, Maxim C-J. Cheeran

Version 1. bioRxiv. Preprint. 2023 Aug 14. doi: 10.1101/2023.08.11.552998

PMCID:: PMC10462071

Article PDF–1.8M

Select item 788591211.

Pathogenesis, Symptomatology, and Transmission of SARS-CoV-2 through Analysis of Viral Genomics and Structure

Halie M. Rando, Adam L. MacLean, Alexandra J. Lee, Ronan Lordan, Sandipan Ray, Vikas Bansal, Ashwin N. Skelly, Elizabeth Sell, John J. Dziak, Lamonica Shinholster, Lucy D’Agostino McGowan, Marouen Ben Guebila, Nils Wellhausen, Sergey Knyazev, Simina M. Boca, Stephen Capone, Yanjun Qi, YoSon Park, Yuchen Sun, David Mai, Joel D Boerckel, Christian Brueffer, James Brian Byrd, Jeremy P. Kamil, Jinhui Wang, Ryan Velazquez, Gregory L Szeto, John P. Barton, Rishi Raj Goel, Serghei Mangul, Tiago Lubiana, COVID-19 Review Consortium, Anthony Gitter, Casey S. Greene

Version 4. ArXiv. Preprint. NaN NaN [revised 2021 Feb 1]: arXiv:2102.01521v4.

Published in:: mSystems. 2021 Sep-Oct; 6(5): e00095-21.

PMCID:: PMC7885912

Article PDF–1.3M

Select item 835177512.

Structural Basis and Mode of Action for Two Broadly Neutralizing Antibodies Against SARS-CoV-2 Emerging Variants of Concern

Wenwei Li, Yaozong Chen, Jérémie Prévost, Irfan Ullah, Maolin Lu, Shang Yu Gong, Alexandra Tauzin, Romain Gasser, Dani Vézina, Sai Priya Anand, Guillaume Goyette, Debashree Chaterjee, Shilei Ding, William D. Tolbert, Michael W. Grunst, Yuxia Bo, Shijian Zhang, Jonathan Richard, Fei Zhou, Rick K. Huang, Lothar Esser, Allison Zeher, Marceline Côté, Priti Kumar, Joseph Sodroski, Di Xia, Pradeep D. Uchil, Marzena Pazgier, Andrés Finzi, Walther Mothes

Version 1. bioRxiv. Preprint. 2021 Aug 3. doi: 10.1101/2021.08.02.454546

Published in:: Cell Rep. 2022 Jan 11; 38(2): 110210.

PMCID:: PMC8351775

Abstract Article PDF–8.5M

Select item 1024583013.

Cross-Protection Induced by Highly Conserved Human B, CD4^+, and CD8⁺ T Cell Epitopes-Based Coronavirus Vaccine Against Severe Infection, Disease, and Death Caused by Multiple SARS-CoV-2 Variants of Concern

Swayam Prakash, Nisha R. Dhanushkodi, Latifa Zayou, Izabela Coimbra Ibraim, Afshana Quadiri, Pierre Gregoire Coulon, Delia F Tifrea, Berfin Suzler, Mohamed Amin, Amruth Chilukuri, Robert A Edwards, Hawa Vahed, Anthony B Nesburn, Baruch D Kuppermann, Jeffrey B. Ulmer, Daniel Gil, Trevor M. Jones, Lbachir BenMohamed

Version 1. bioRxiv. Preprint. 2023 May 24. doi: 10.1101/2023.05.24.541850

Published in:: Front Immunol. 2024; 15: 1328905.

PMCID:: PMC10245830

Article PDF–6.8M

Select item 766874114.

A multi-pronged approach targeting SARS-CoV-2 proteins using ultra-large virtual screening

Christoph Gorgulla, Krishna M. Padmanabha Das, Kendra E. Leigh, Marco Cespugli, Patrick D. Fischer, Zi-Fu Wang, Guilhem Tesseyre, Shreya Pandita, Alec Shnapir, Anthony Calderaio, Minko Gechev, Alexander Rose, Noam Lewis, Colin Hutcheson, Erez Yaffe, Roni Luxenburg, Henry D. Herce, Vedat Durmaz, Thanos D. Halazonetis, Konstantin Fackeldey, Justin J. Patten, Alexander Chuprina, Igor Dziuba, Alla Plekhova, Yurii Moroz, Dmytro Radchenko, Olga Tarkhanova, Irina Yavnyuk, Christian Gruber, Ryan Yust, Dave Payne, Anders M. Näär, Mark N. Namchuk, Robert A. Davey, Gerhard Wagner, Jamie Kinney, Haribabu Arthanari

Version 1. ChemRxiv. Preprint. 2020 Jul 24. doi: 10.26434/chemrxiv.12682316

Published in:: iScience. 2021 Feb 19; 24(2): 102021.

PMCID:: PMC7668741

Abstract Article PDF–15M

Select item 816838515.

Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal HCoVs

Antoine Rebendenne, Priyanka Roy, Boris Bonaventure, Valadão Ana Luiza Chaves, Lowiese Desmarets, Yves Rouillé, Marine Tauziet, Mary Arnaud-Arnould, Donatella Giovannini, Yenarae Lee, Peter DeWeirdt, Mudra Hegde, Gracia Francisco Garcia de, Joe McKellar, Mélanie Wencker, Jean Dubuisson, Sandrine Belouzard, Olivier Moncorgé, John G. Doench, Caroline Goujon

Version 1. Res Sq. Preprint. 2021 May 27. doi: 10.21203/rs.3.rs-555275/v1

Published in:: Nat Genet. 2022 Jul 25

PMCID:: PMC8168385

Abstract Article PDF–13M

Select item 792426716.

A single-cell and spatial atlas of autopsy tissues reveals pathology and cellular targets of SARS-CoV-2

Toni M. Delorey, Carly G. K. Ziegler, Graham Heimberg, Rachelly Normand, Yiming Yang, Asa Segerstolpe, Domenic Abbondanza, Stephen J. Fleming, Ayshwarya Subramanian, Daniel T. Montoro, Karthik A. Jagadeesh, Kushal K. Dey, Pritha Sen, Michal Slyper, Yered H. Pita-Juárez, Devan Phillips, Zohar Bloom-Ackerman, Nick Barkas, Andrea Ganna, James Gomez, Erica Normandin, Pourya Naderi, Yury V. Popov, Siddharth S. Raju, Sebastian Niezen, Linus T.-Y. Tsai, Katherine J. Siddle, Malika Sud, Victoria M. Tran, Shamsudheen K. Vellarikkal, Liat Amir-Zilberstein, Deepak S. Atri, Joseph Beechem, Olga R. Brook, Jonathan Chen, Prajan Divakar, Phylicia Dorceus, Jesse M. Engreitz, Adam Essene, Donna M. Fitzgerald, Robin Fropf, Steven Gazal, Joshua Gould, John Grzyb, Tyler Harvey, Jonathan Hecht, Tyler Hether, Judit Jane-Valbuena, Michael Leney-Greene, Hui Ma, Cristin McCabe, Daniel E. McLoughlin, Eric M. Miller, Christoph Muus, Mari Niemi, Robert Padera, Liuliu Pan, Deepti Pant, Carmel Pe’er, Jenna Pfiffner-Borges, Christopher J. Pinto, Jacob Plaisted, Jason Reeves, Marty Ross, Melissa Rudy, Erroll H. Rueckert, Michelle Siciliano, Alexander Sturm, Ellen Todres, Avinash Waghray, Sarah Warren, Shuting Zhang, Daniel R. Zollinger, Lisa Cosimi, Rajat M. Gupta, Nir Hacohen, Winston Hide, Alkes L. Price, Jayaraj Rajagopal, Purushothama Rao Tata, Stefan Riedel, Gyongyi Szabo, Timothy L. Tickle, Deborah Hung, Pardis C. Sabeti, Richard Novak, Robert Rogers, Donald E. Ingber, Z. Gordon Jiang, Dejan Juric, Mehrtash Babadi, Samouil L. Farhi, James R. Stone, Ioannis S. Vlachos, Isaac H. Solomon, Orr Ashenberg, Caroline B.M. Porter, Bo Li, Alex K. Shalek, Alexandra-Chloé Villani, Orit Rozenblatt-Rosen, Aviv Regev

Version 1. bioRxiv. Preprint. 2021 Feb 25. doi: 10.1101/2021.02.25.430130

PMCID:: PMC7924267

Abstract Article PDF–33M

Select item 789945217.

Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19

Carly G. K. Ziegler, Vincent N. Miao, Anna H. Owings, Andrew W. Navia, Ying Tang, Joshua D. Bromley, Peter Lotfy, Meredith Sloan, Hannah Laird, Haley B. Williams, Micayla George, Riley S. Drake, Taylor Christian, Adam Parker, Campbell B. Sindel, Molly W. Burger, Yilianys Pride, Mohammad Hasan, George E. Abraham, III, Michal Senitko, Tanya O. Robinson, Alex K. Shalek, Sarah C. Glover, Bruce H. Horwitz, Jose Ordovas-Montanes

Version 1. bioRxiv. Preprint. 2021 Feb 20. doi: 10.1101/2021.02.20.431155

Published in:: Cell. 2021 Sep 2; 184(18): 4713–4733.e22.

PMCID:: PMC7899452

Abstract Article PDF–39M

Select item 1024614318.

Distinct T cell functional profiles in SARS-CoV-2 seropositive and seronegative children associated with endemic human coronavirus cross-reactivity

Ntombi S. B. Benede, Marius B. Tincho, Avril Walters, Vennesa Subbiah, Amkele Ngomti, Richard Baguma, Claire Butters, Mathilda Mennen, Sango Skelem, Marguerite Adriaanse, Strauss van Graan, Sashkia R. Balla, Thandeka Moyo-Gwete, Penny L. Moore, Maresa Botha, Lesley Workman, Heather J. Zar, Ntobeko A. B. Ntusi, Liesl Zühlke, Kate Webb, Catherine Riou, Wendy A. Burgers, Roanne S. Keeton

Version 1. medRxiv. Preprint. 2023 May 23. doi: 10.1101/2023.05.16.23290059

Published in:: iScience. 2024 Jan 19; 27(1): 108728.

PMCID:: PMC10246143

Article PDF–560K

Select item 977421119.

Surface-modified measles vaccines encoding oligomeric, fusion-stabilized SARS-CoV-2 spike glycoproteins bypass measles seropositivity, boosting neutralizing antibody responses to omicron and historical variants

Miguel Á. Muñoz-Alía, Rebecca A. Nace, Baskar Balakrishnan, Lianwen Zhang, Nandakumar Packiriswamy, Gagandeep Singh, Prajakta Warang, Ignacio Mena, Riya Narjari, Rianna Vandergaast, Adolfo García-Sastre, Michael Schotsaert, Stephen J. Russell

Version 1. bioRxiv. Preprint. 2022 Dec 16. doi: 10.1101/2022.12.16.520799

Published in:: mBio. 2024 Feb; 15(2): e02928-23.

PMCID:: PMC9774211

Article PDF–3.9M

Select item 802097320.

A human antibody reveals a conserved site on beta-coronavirus spike proteins and confers protection against SARS-CoV-2 infection

Panpan Zhou, Meng Yuan, Ge Song, Nathan Beutler, Namir Shaabani, Deli Huang, Wan-ting He, Xueyong Zhu, Sean Callaghan, Peter Yong, Fabio Anzanello, Linghang Peng, James Ricketts, Mara Parren, Elijah Garcia, Stephen A. Rawlings, Davey M. Smith, David Nemazee, John R. Teijaro, Thomas F. Rogers, Ian A. Wilson, Dennis R. Burton, Raiees Andrabi

Version 2. bioRxiv. Preprint. 2021 Mar 31 [revised 2022 Jan 21]. doi: 10.1101/2021.03.30.437769

Published in:: Sci Transl Med. 2022 Feb 8 : eabi9215.

PMCID:: PMC8020973

Abstract Article PDF–2.9M

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